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Fusion gene ID: 27734 |
FusionGeneSummary for PLXNA2_DUSP10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNA2_DUSP10 | Fusion gene ID: 27734 | Hgene | Tgene | Gene symbol | PLXNA2 | DUSP10 | Gene ID | 5362 | 11221 |
| Gene name | plexin A2 | dual specificity phosphatase 10 | |
| Synonyms | OCT|PLXN2 | MKP-5|MKP5 | |
| Cytomap | 1q32.2 | 1q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-A2plexin 2semaphorin receptor OCTtransmembrane protein OCT | dual specificity protein phosphatase 10dual specificity phosphatase MKP-5map kinase phosphatase 5mitogen-activated protein kinase phosphatase 5serine/threonine specific protein phosphatase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75051 | Q9Y6W6 | |
| Ensembl transtripts involved in fusion gene | ENST00000367033, ENST00000483048, | ENST00000544095, ENST00000323825, ENST00000366899, ENST00000468085, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PLXNA2 [Title/Abstract] AND DUSP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DUSP10 | GO:0000188 | inactivation of MAPK activity | 22375048 |
| Tgene | DUSP10 | GO:0006470 | protein dephosphorylation | 22375048 |
| Tgene | DUSP10 | GO:0016311 | dephosphorylation | 24531476 |
| Tgene | DUSP10 | GO:0035970 | peptidyl-threonine dephosphorylation | 10391943 |
| Tgene | DUSP10 | GO:0043508 | negative regulation of JUN kinase activity | 10391943 |
| Tgene | DUSP10 | GO:0046329 | negative regulation of JNK cascade | 10391943 |
| Tgene | DUSP10 | GO:1903753 | negative regulation of p38MAPK cascade | 10391943 |
| Tgene | DUSP10 | GO:1990264 | peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity | 10391943 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A24Z-01A | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000367033 | ENST00000544095 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| 5CDS-5UTR | ENST00000367033 | ENST00000323825 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| 5CDS-5UTR | ENST00000367033 | ENST00000366899 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| 5CDS-5UTR | ENST00000367033 | ENST00000468085 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| intron-5UTR | ENST00000483048 | ENST00000544095 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| intron-5UTR | ENST00000483048 | ENST00000323825 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| intron-5UTR | ENST00000483048 | ENST00000366899 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
| intron-5UTR | ENST00000483048 | ENST00000468085 | PLXNA2 | chr1 | 208383625 | - | DUSP10 | chr1 | 221879808 | - |
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FusionProtFeatures for PLXNA2_DUSP10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNA2 | DUSP10 |
| Coreceptor for SEMA3A and SEMA6A. Necessary forsignaling by SEMA6A and class 3 semaphorins and subsequentremodeling of the cytoskeleton. Plays a role in axon guidance,invasive growth and cell migration. Class 3 semaphorins bind to acomplex composed of a neuropilin and a plexin. The plexinmodulates the affinity of the complex for specific semaphorins,and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).{ECO:0000250, ECO:0000269|PubMed:10520995}. | Protein phosphatase involved in the inactivation of MAPkinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14subfamily. It preferably dephosphorylates p38.{ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297,ECO:0000269|PubMed:22375048}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLXNA2_DUSP10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLXNA2_DUSP10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLXNA2 | UBAP2L, FNBP4, CEMIP, IFT80, TAZ, NUFIP1, SUSD4, PTPRK, TNF, GPHA2, XAB2, LACRT, FAM19A4, TMEM30B, SCGB1D1, OS9, DEFA1, ST8SIA4, DEFA5, TCTN2, ADAM32, ADAM21, MPPE1, SPINK4, SLAMF1, CCL22, INSL5, KIR3DL2, CD1E, ADAM30, GALNT6, TRIM25 | DUSP10 | MAPK14, MAPK8, MAPK9, MAPK10, CMTM6, HTT, SNX2, FHL2, FN1, RPS11, SLX1B, CASK, OTUD4, ACTBL2, ACTA2, EFHD1, ACTB, PTPN2, ERBB4, ROR2, IGF1R, PTK7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNA2_DUSP10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNA2_DUSP10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLXNA2 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | PLXNA2 | C0338908 | Mixed anxiety and depressive disorder | 1 | PSYGENET |
| Tgene | DUSP10 | C0021368 | Inflammation | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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