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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 277

FusionGeneSummary for ABLIM3_CDK14

check button Fusion gene summary
Fusion gene informationFusion gene name: ABLIM3_CDK14
Fusion gene ID: 277
HgeneTgene
Gene symbol

ABLIM3

CDK14

Gene ID

22885

5218

Gene nameactin binding LIM protein family member 3cyclin dependent kinase 14
SynonymsHMFN1661PFTAIRE1|PFTK1
Cytomap

5q32

7q21.13

Type of geneprotein-codingprotein-coding
Descriptionactin-binding LIM protein 3abLIM-3cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1
Modification date2018052320180523
UniProtAcc

O94929

O94921

Ensembl transtripts involved in fusion geneENST00000326685, ENST00000356541, 
ENST00000309868, ENST00000506113, 
ENST00000504238, ENST00000508983, 
ENST00000517451, ENST00000519549, 
ENST00000380050, ENST00000265741, 
ENST00000406263, ENST00000436577, 
ENST00000496279, 
Fusion gene scores* DoF score3 X 3 X 2=1817 X 14 X 9=2142
# samples 319
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/2142*10)=-3.49488715641931
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABLIM3 [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE178202ABLIM3chr5

148638027

+CDK14chr7

90377073

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000326685ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000326685ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000326685ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000326685ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000326685ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000356541ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000356541ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000356541ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000356541ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000356541ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000309868ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000309868ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000309868ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000309868ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000309868ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000506113ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000506113ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-3CDSENST00000506113ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000506113ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
3UTR-intronENST00000506113ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000504238ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000504238ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000504238ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000504238ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000504238ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000508983ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000508983ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000508983ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000508983ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000508983ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000517451ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000517451ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000517451ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000517451ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000517451ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000519549ENST00000380050ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000519549ENST00000265741ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-3CDSENST00000519549ENST00000406263ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000519549ENST00000436577ABLIM3chr5

148638027

+CDK14chr7

90377073

-
intron-intronENST00000519549ENST00000496279ABLIM3chr5

148638027

+CDK14chr7

90377073

-

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FusionProtFeatures for ABLIM3_CDK14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABLIM3

O94929

CDK14

O94921

May act as scaffold protein. May stimulate ABRA activityand ABRA-dependent SRF transcriptional activity.{ECO:0000269|PubMed:17194709}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABLIM3_CDK14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABLIM3_CDK14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABLIM3_CDK14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABLIM3_CDK14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABLIM3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCDK14C2239176Liver carcinoma1CTD_human