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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27682

FusionGeneSummary for PLIN2_CA10

check button Fusion gene summary
Fusion gene informationFusion gene name: PLIN2_CA10
Fusion gene ID: 27682
HgeneTgene
Gene symbol

PLIN2

CA10

Gene ID

123

56934

Gene nameperilipin 2carbonic anhydrase 10
SynonymsADFP|ADRPCA-RPX|CARPX|HUCEP-15
Cytomap

9p22.1

17q21.33-q22

Type of geneprotein-codingprotein-coding
Descriptionperilipin-2adipophilinadipose differentiation-related proteincarbonic anhydrase-related protein 10CA-RP XCARP Xcarbonic anhydrase Xcarbonic anhydrase-related protein Xcerebral protein-15
Modification date2018051920180522
UniProtAcc

Q99541

Q9NS85

Ensembl transtripts involved in fusion geneENST00000494753, ENST00000411567, 
ENST00000276914, ENST00000380465, 
ENST00000380464, 
ENST00000570565, 
ENST00000442502, ENST00000340813, 
ENST00000451037, ENST00000285273, 
ENST00000571918, 
Fusion gene scores* DoF score1 X 1 X 1=118 X 7 X 8=1008
# samples 118
** MAII scorelog2(1/1*10)=3.32192809488736log2(18/1008*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLIN2 [Title/Abstract] AND CA10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1JA-01APLIN2chr9

19123563

-CA10chr17

49825178

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000494753ENST00000570565PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000494753ENST00000442502PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000494753ENST00000340813PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000494753ENST00000451037PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000494753ENST00000285273PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-5UTRENST00000494753ENST00000571918PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000411567ENST00000570565PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000411567ENST00000442502PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000411567ENST00000340813PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000411567ENST00000451037PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000411567ENST00000285273PLIN2chr9

19123563

-CA10chr17

49825178

-
5CDS-5UTRENST00000411567ENST00000571918PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000276914ENST00000570565PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000276914ENST00000442502PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000276914ENST00000340813PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000276914ENST00000451037PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000276914ENST00000285273PLIN2chr9

19123563

-CA10chr17

49825178

-
5CDS-5UTRENST00000276914ENST00000571918PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000380465ENST00000570565PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000380465ENST00000442502PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000380465ENST00000340813PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000380465ENST00000451037PLIN2chr9

19123563

-CA10chr17

49825178

-
Frame-shiftENST00000380465ENST00000285273PLIN2chr9

19123563

-CA10chr17

49825178

-
5CDS-5UTRENST00000380465ENST00000571918PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000380464ENST00000570565PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000380464ENST00000442502PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000380464ENST00000340813PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000380464ENST00000451037PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-3CDSENST00000380464ENST00000285273PLIN2chr9

19123563

-CA10chr17

49825178

-
intron-5UTRENST00000380464ENST00000571918PLIN2chr9

19123563

-CA10chr17

49825178

-

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FusionProtFeatures for PLIN2_CA10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLIN2

Q99541

CA10

Q9NS85

May be involved in development and maintenance ofadipose tissue. {ECO:0000250}. Does not have a catalytic activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLIN2_CA10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLIN2_CA10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLIN2MAPK10, APOB, LIPECA10PARL, MTHFD1, WDHD1, TSC22D1, IMPACT, ASS1, CALCOCO1, TOR1AIP1, PHYHIP, COL6A2, ABT1, INO80, ACTR10, MTERF4, G6PD, LYRM7, NRBP1, NSUN4, PSMG1, KCTD15, PIAS4, PSMG2, PSMG3, PSMG4, DCTN3, PPRC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLIN2_CA10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCA10Q9NS85DB00909ZonisamideCarbonic anhydrase-related protein 10small moleculeapproved|investigational

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RelatedDiseases for PLIN2_CA10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLIN2C0015695Fatty Liver1CTD_human
HgenePLIN2C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePLIN2C0038356Stomach Neoplasms1CTD_human