FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27677

FusionGeneSummary for PLEK_PLEK

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEK_PLEK
Fusion gene ID: 27677
HgeneTgene
Gene symbol

PLEK

PLEK

Gene ID

5341

5341

Gene namepleckstrinpleckstrin
SynonymsP47P47
Cytomap

2p14

2p14

Type of geneprotein-codingprotein-coding
Descriptionpleckstrinplatelet 47 kDa proteinpleckstrinplatelet 47 kDa protein
Modification date2018051920180519
UniProtAcc

P08567

P08567

Ensembl transtripts involved in fusion geneENST00000234313, ENST00000234313, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PLEK [Title/Abstract] AND PLEK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEK

GO:0007229

integrin-mediated signaling pathway

10995449

HgenePLEK

GO:0010920

negative regulation of inositol phosphate biosynthetic process

7559487|7782310

HgenePLEK

GO:0010925

positive regulation of inositol-polyphosphate 5-phosphatase activity

8999861

HgenePLEK

GO:0030030

cell projection organization

9060471

HgenePLEK

GO:0030836

positive regulation of actin filament depolymerization

10497244

HgenePLEK

GO:0030845

phospholipase C-inhibiting G-protein coupled receptor signaling pathway

7782310

HgenePLEK

GO:0030866

cortical actin cytoskeleton organization

10497244

HgenePLEK

GO:0031529

ruffle organization

10497244

HgenePLEK

GO:0031532

actin cytoskeleton reorganization

10497244

HgenePLEK

GO:0032233

positive regulation of actin filament bundle assembly

10497244

HgenePLEK

GO:0045744

negative regulation of G-protein coupled receptor protein signaling pathway

7782310

HgenePLEK

GO:0046488

phosphatidylinositol metabolic process

7559487

HgenePLEK

GO:0060305

regulation of cell diameter

10995449

HgenePLEK

GO:0070493

thrombin-activated receptor signaling pathway

7782310

TgenePLEK

GO:0007229

integrin-mediated signaling pathway

10995449

TgenePLEK

GO:0010920

negative regulation of inositol phosphate biosynthetic process

7559487|7782310

TgenePLEK

GO:0010925

positive regulation of inositol-polyphosphate 5-phosphatase activity

8999861

TgenePLEK

GO:0030030

cell projection organization

9060471

TgenePLEK

GO:0030836

positive regulation of actin filament depolymerization

10497244

TgenePLEK

GO:0030845

phospholipase C-inhibiting G-protein coupled receptor signaling pathway

7782310

TgenePLEK

GO:0030866

cortical actin cytoskeleton organization

10497244

TgenePLEK

GO:0031529

ruffle organization

10497244

TgenePLEK

GO:0031532

actin cytoskeleton reorganization

10497244

TgenePLEK

GO:0032233

positive regulation of actin filament bundle assembly

10497244

TgenePLEK

GO:0045744

negative regulation of G-protein coupled receptor protein signaling pathway

7782310

TgenePLEK

GO:0046488

phosphatidylinositol metabolic process

7559487

TgenePLEK

GO:0060305

regulation of cell diameter

10995449

TgenePLEK

GO:0070493

thrombin-activated receptor signaling pathway

7782310


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB046501PLEKchr2

68623562

+PLEKchr2

68613714

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000234313ENST00000234313PLEKchr2

68623562

+PLEKchr2

68613714

+

Top

FusionProtFeatures for PLEK_PLEK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLEK

P08567

PLEK

P08567

Major protein kinase C substrate of platelets. Major protein kinase C substrate of platelets.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PLEK_PLEK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PLEK_PLEK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PLEK_PLEK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PLEK_PLEK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLEKC0003873Rheumatoid Arthritis1CTD_human
HgenePLEKC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePLEKC0029456Osteoporosis1CTD_human
TgenePLEKC0003873Rheumatoid Arthritis1CTD_human
TgenePLEKC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLEKC0029456Osteoporosis1CTD_human