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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2765

FusionGeneSummary for ARMC8_MRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC8_MRAS
Fusion gene ID: 2765
HgeneTgene
Gene symbol

ARMC8

MRAS

Gene ID

25852

22808

Gene namearmadillo repeat containing 8muscle RAS oncogene homolog
SynonymsGID5|HSPC056|S863-2|VID28M-RAs|R-RAS3|RRAS3
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 8GID complex subunit 5, VID28 homologras-related protein M-Rasmuscle and microspikes RASras-related protein R-Ras3
Modification date2018052320180522
UniProtAcc

Q8IUR7

O14807

Ensembl transtripts involved in fusion geneENST00000481646, ENST00000469044, 
ENST00000491704, ENST00000358441, 
ENST00000489213, ENST00000461822, 
ENST00000485396, ENST00000471453, 
ENST00000470821, ENST00000393058, 
ENST00000538260, 		ENST00000289104, 
ENST00000423968, ENST00000464896, 
ENST00000461114, ENST00000474559, 
Fusion gene scores* DoF score8 X 7 X 5=2803 X 3 X 3=27
# samples 94
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARMC8 [Title/Abstract] AND MRAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A8I5-01AARMC8chr3

137907372

+MRASchr3

138091708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000481646ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000481646ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000481646ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000481646ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000481646ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000469044ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000469044ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-intronENST00000491704ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-intronENST00000491704ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000358441ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000358441ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000358441ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000358441ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000358441ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000489213ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000489213ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000461822ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000461822ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000485396ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000485396ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000471453ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000471453ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000470821ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000470821ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000393058ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000393058ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000538260ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000538260ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+

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FusionProtFeatures for ARMC8_MRAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC8

Q8IUR7

MRAS

O14807

May serve as an important signal transducer for a novelupstream stimuli in controlling cell proliferation. Weaklyactivates the MAP kinase pathway. {ECO:0000269|PubMed:16630891}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARMC8_MRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMC8_MRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARMC8RAE1, TNNT1, CTNNB1, CTNNA1, HGS, CUL3, NOTCH1, SOX2, EGFR, TCF12, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, GPS2, MRPL39, PDHB, HLA-DPB1, RMND5A, MRPS30, IKZF3, PRG2, TCF4, TIGD5, BMP1, PRG3, PIGT, PRICKLE3, CCDC120, MRPS24, CUTA, MPP2, INSL6, MRPL38, NDUFS6, LILRB4, NKAP, SPINK7, JPH4, NFATC1, TLE4, LCA5, ADCYAP1, NCKIPSD, IKZF1, CDK5RAP1, ANGPTL4, ARHGAP22, HAPLN3, PTPN14, PTPN21, MKLN1, RANBP10, MAEA, WDR26, RANBP9, YPEL5, RMND5B, GID4, UBE2H, ZMYND19, HTRA2, GID8, DDX5, EFHC2, RAB8A, WWC1MRASRALGDS, RAF1, RASSF5, BRAF, RAPGEF5, RAPGEF6, TCEB1, SHOC2, HUWE1, RHOU, PSMC5, PKLR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARMC8_MRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARMC8_MRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMRASC0007273Carotid Artery Diseases1CTD_human
TgeneMRASC1956346Coronary Artery Disease1CTD_human