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Fusion gene ID: 27636 |
FusionGeneSummary for PLEKHG4B_AHRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHG4B_AHRR | Fusion gene ID: 27636 | Hgene | Tgene | Gene symbol | PLEKHG4B | AHRR | Gene ID | 153478 | 57491 |
| Gene name | pleckstrin homology and RhoGEF domain containing G4B | aryl-hydrocarbon receptor repressor | |
| Synonyms | - | AHH|AHHR|bHLHe77 | |
| Cytomap | 5p15.33 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family G member 4BPH domain-containing family G member 4Bpleckstrin homology domain containing, family G (with RhoGef domain) member 4B | aryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | Q96PX9 | A9YTQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000283426, | ENST00000505113, ENST00000316418, ENST00000512529, ENST00000515206, ENST00000506456, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 6 X 4 X 4=96 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHG4B [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-22-1016-01A | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| TCGA | LD | LUSC | TCGA-52-7810-01A | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000283426 | ENST00000505113 | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| Frame-shift | ENST00000283426 | ENST00000316418 | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| 5CDS-5UTR | ENST00000283426 | ENST00000512529 | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| 5CDS-5UTR | ENST00000283426 | ENST00000515206 | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| 5CDS-intron | ENST00000283426 | ENST00000506456 | PLEKHG4B | chr5 | 145035 | + | AHRR | chr5 | 344008 | + |
| Frame-shift | ENST00000283426 | ENST00000505113 | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
| Frame-shift | ENST00000283426 | ENST00000316418 | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
| 5CDS-5UTR | ENST00000283426 | ENST00000512529 | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
| 5CDS-5UTR | ENST00000283426 | ENST00000515206 | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
| 5CDS-intron | ENST00000283426 | ENST00000506456 | PLEKHG4B | chr5 | 151714 | + | AHRR | chr5 | 344008 | + |
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FusionProtFeatures for PLEKHG4B_AHRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHG4B | AHRR |
| Mediates dioxin toxicity and is involved in regulationof cell growth and differentiation. Represses the transcriptionactivity of AHR by competing with this transcription factor forheterodimer formation with the ARNT and subsequently binding tothe xenobiotic response element (XRE) sequence present in thepromoter regulatory region of variety of genes. Represses CYP1A1by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/orHDAC5. Autoregulates its expression by associating with its ownXRE site. {ECO:0000269|PubMed:17890447,ECO:0000269|PubMed:18172554}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLEKHG4B_AHRR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLEKHG4B_AHRR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHG4B | AHRR | ARNT, ESR1, HDAC4, HDAC5, ANKRA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHG4B_AHRR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHG4B_AHRR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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