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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27626

FusionGeneSummary for PLEKHF2_TRIQK

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHF2_TRIQK
Fusion gene ID: 27626
HgeneTgene
Gene symbol

PLEKHF2

TRIQK

Gene ID

79666

286144

Gene namepleckstrin homology and FYVE domain containing 2triple QxxK/R motif containing
SynonymsEAPF|PHAFIN2|ZFYVE18C8orf83|PRO0845|UPF0599
Cytomap

8q22.1

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family F member 2PH and FYVE domain-containing protein 2PH domain-containing family F member 2endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domainspleckstrin homology domain cotriple QxxK/R motif-containing proteinprotein TRIQKtriple repetitive-sequence of QXXK/R protein homolog
Modification date2018052320180403
UniProtAcc

Q9H8W4

Q629K1

Ensembl transtripts involved in fusion geneENST00000315367, ENST00000519516, 
ENST00000520686, ENST00000521988, 
ENST00000537541, ENST00000518748, 
ENST00000523580, ENST00000520430, 
ENST00000517858, ENST00000517540, 
ENST00000378861, ENST00000524037, 
ENST00000521617, ENST00000519069, 
ENST00000524107, ENST00000519969, 
Fusion gene scores* DoF score2 X 1 X 2=45 X 4 X 4=80
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHF2 [Title/Abstract] AND TRIQK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-41-3915-01APLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000315367ENST00000520686PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000521988PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-intronENST00000315367ENST00000537541PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000518748PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-intronENST00000315367ENST00000523580PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-intronENST00000315367ENST00000520430PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000517858PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000517540PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000378861PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000524037PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-intronENST00000315367ENST00000521617PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-intronENST00000315367ENST00000519069PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000524107PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
5UTR-5UTRENST00000315367ENST00000519969PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000520686PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000521988PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-intronENST00000519516ENST00000537541PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000518748PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-intronENST00000519516ENST00000523580PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-intronENST00000519516ENST00000520430PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000517858PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000517540PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000378861PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000524037PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-intronENST00000519516ENST00000521617PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-intronENST00000519516ENST00000519069PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000524107PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-
intron-5UTRENST00000519516ENST00000519969PLEKHF2chr8

96146258

+TRIQKchr8

93966792

-

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FusionProtFeatures for PLEKHF2_TRIQK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLEKHF2

Q9H8W4

TRIQK

Q629K1

May play a role in early endosome fusion upstream ofRAB5, hence regulating receptor trafficking and fluid-phasetransport. Enhances cellular sensitivity to TNF-induced apoptosis(PubMed:18288467). {ECO:0000269|PubMed:18288467,ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}. May play a role in cell growth and maintenance of cellmorphology. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLEKHF2_TRIQK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLEKHF2_TRIQK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLEKHF2BLOC1S6, SFN, GNMT, RTN4, GLUL, SPEF1, GPBP1L1, NONO, RTN1, RTN3, RABAC1, TSC22D3, MBIP, PRKAR1A, UBE2Z, SDPR, CCDC85B, ZNF263, PRPSAP1, MAX, CHIC2, ELAVL1, APP, DUT, MEAF6, BEND7, APPL1, LDOC1, FHL3, GFER, SEPT2, S100A1, S100A13, TRAF6, AIMP2, NPM2, SEPT6, FBXO28, TNFAIP8, SETBP1, BSCL2, TRAPPC3, HSPB7, TXNL4B, ZNF398, ZNF250, GPBP1, CEP44, FRMD8, L3MBTL3, ACY3, DTX2, RSPO2, SHMT2, MOV10, DRAP1, ARL14EP, CCDC172, SEPT5, CXorf57, DPPA4, PRDM14, AIDA, TBX3, USF1, CGGBP1, THOC2TRIQK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLEKHF2_TRIQK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLEKHF2_TRIQK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource