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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27620

FusionGeneSummary for PLEKHD1_SLC39A9

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHD1_SLC39A9
Fusion gene ID: 27620
HgeneTgene
Gene symbol

PLEKHD1

SLC39A9

Gene ID

400224

55334

Gene namepleckstrin homology and coiled-coil domain containing D1solute carrier family 39 member 9
SynonymsUPF0639ZIP-9|ZIP9
Cytomap

14q24.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family D member 1PH domain-containing family D member 1UPF0639 proteinpleckstrin homology domain containing, family D (with M protein repeats) member 1pleckstrin homology domain containing, family D (with coiled-czinc transporter ZIP9solute carrier family 39 (zinc transporter), member 9zinc transporter SLC39A9zrt- and Irt-like protein 9
Modification date2018032920180519
UniProtAcc

A6NEE1

Q9NUM3

Ensembl transtripts involved in fusion geneENST00000322564, ENST00000555245, 
ENST00000556605, ENST00000336643, 
ENST00000031146, ENST00000557046, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 5 X 4=80
# samples 26
** MAII scorelog2(2/1*10)=4.32192809488736log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHD1 [Title/Abstract] AND SLC39A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1KF612914PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
ChiTaRS3.1KF612915PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000322564ENST00000555245PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
5CDS-3UTRENST00000322564ENST00000556605PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
5CDS-3UTRENST00000322564ENST00000336643PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
5CDS-3UTRENST00000322564ENST00000031146PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+
5CDS-3UTRENST00000322564ENST00000557046PLEKHD1chr14

69969597

+SLC39A9chr14

69922447

+

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FusionProtFeatures for PLEKHD1_SLC39A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLEKHD1

A6NEE1

SLC39A9

Q9NUM3

May act as a zinc-influx transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLEKHD1_SLC39A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLEKHD1_SLC39A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLEKHD1SLC39A9MOV10, NXF1, CD44, TTI2, FKRP, HIP1R, DNAJC13, TPST2, SLC25A24, OSTC, HPCAL1, CANT1, SYNGR3, METTL16, KIAA0368, SFXN5, MTX3, TTK, RMND1, GOLM1, SRPR, B4GALT5, STIM1, NR2F2, MTFP1, CDC23, IDH2, SLC25A17, HELLS, DNM1, ABCB8, MSH3, PXMP2, NEK7, PDXDC1, MPC2, BDH1, XPO7, RIF1, CCDC132, VAPB, MTX1, TBRG4, APOOL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLEKHD1_SLC39A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLEKHD1_SLC39A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource