	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 2761

FusionGeneSummary for ARMC8_ARMC8

Fusion gene summary

Fusion gene information	Fusion gene name: ARMC8_ARMC8
	Fusion gene ID: 2761
		Hgene	Tgene
	Gene symbol	ARMC8	ARMC8
	Gene ID	25852	25852
	Gene name	armadillo repeat containing 8	armadillo repeat containing 8
	Synonyms	GID5\|HSPC056\|S863-2\|VID28	GID5\|HSPC056\|S863-2\|VID28
	Cytomap	3q22.3	3q22.3
	Type of gene	protein-coding	protein-coding
	Description	armadillo repeat-containing protein 8GID complex subunit 5, VID28 homolog	armadillo repeat-containing protein 8GID complex subunit 5, VID28 homolog
	Modification date	20180523	20180523
	UniProtAcc	Q8IUR7	Q8IUR7
	Ensembl transtripts involved in fusion gene	ENST00000481646, ENST00000469044, ENST00000491704, ENST00000358441, ENST00000489213, ENST00000461822, ENST00000485396, ENST00000471453, ENST00000470821, ENST00000393058, ENST00000538260,	ENST00000481646, ENST00000469044, ENST00000491704, ENST00000358441, ENST00000489213, ENST00000461822, ENST00000485396, ENST00000471453, ENST00000470821, ENST00000393058, ENST00000538260,
Fusion gene scores	* DoF score	8 X 7 X 5=280	5 X 5 X 4=100
	# samples	9	5
	** MAII score	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARMC8 [Title/Abstract] AND ARMC8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CD644321	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000481646	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000481646	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000469044	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000491704	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000358441	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000489213	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000461822	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000485396	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000471453	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000470821	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000393058	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000481646	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000469044	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000491704	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000358441	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000489213	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000461822	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000485396	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000471453	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000470821	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000393058	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+
intron-intron	ENST00000538260	ENST00000538260	ARMC8	chr3	137954017	-	ARMC8	chr3	137953624	+

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FusionProtFeatures for ARMC8_ARMC8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARMC8 Q8IUR7	ARMC8 Q8IUR7

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ARMC8_ARMC8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMC8_ARMC8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ARMC8_ARMC8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ARMC8_ARMC8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 2761

FusionGeneSummary for ARMC8_ARMC8

FusionProtFeatures for ARMC8_ARMC8

FusionGeneSequence for ARMC8_ARMC8

FusionGenePPI for ARMC8_ARMC8

RelatedDrugs for ARMC8_ARMC8

RelatedDiseases for ARMC8_ARMC8