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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2760

FusionGeneSummary for ARMC7_NUP85

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7_NUP85
Fusion gene ID: 2760
HgeneTgene
Gene symbol

ARMC7

NUP85

Gene ID

79637

79902

Gene namearmadillo repeat containing 7nucleoporin 85
Synonyms-FROUNT|Nup75
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 7nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85
Modification date2018051920180523
UniProtAcc

Q9H6L4

Q9BW27

Ensembl transtripts involved in fusion geneENST00000581078, ENST00000582136, 
ENST00000245543, ENST00000584947, 
ENST00000579096, 		ENST00000245544, 
ENST00000541827, ENST00000579324, 
ENST00000449421, ENST00000579298, 
ENST00000447371, ENST00000540768, 
Fusion gene scores* DoF score4 X 1 X 3=128 X 7 X 5=280
# samples 410
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-62-A46U-01AARMC7chr17

73106701

+NUP85chr17

73221198

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000581078ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000581078ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000581078ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3UTRENST00000581078ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000581078ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000582136ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000582136ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000582136ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000245543ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000245543ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000245543ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
Frame-shiftENST00000584947ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-3UTRENST00000584947ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
5CDS-intronENST00000584947ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000245544ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000541827ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3CDSENST00000579096ENST00000579324ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-3UTRENST00000579096ENST00000449421ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000579298ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000447371ARMC7chr17

73106701

+NUP85chr17

73221198

+
intron-intronENST00000579096ENST00000540768ARMC7chr17

73106701

+NUP85chr17

73221198

+

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FusionProtFeatures for ARMC7_NUP85


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC7

Q9H6L4

NUP85

Q9BW27

Essential component of the nuclear pore complex (NPC)that seems to be required for NPC assembly and maintenance(PubMed:12718872). As part of the NPC Nup107-160 subcomplex playsa role in RNA export and in tethering NUP96/Nup98 and NUP153 tothe nucleus (PubMed:12718872). The Nup107-160 complex seems to berequired for spindle assembly during mitosis (PubMed:16807356).NUP85 is required for membrane clustering of CCL2-activated CCR2(PubMed:15995708). Seems to be involved in CCR2-mediatedchemotaxis of monocytes and may link activated CCR2 to thephosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusioncascade (PubMed:15995708). {ECO:0000269|PubMed:12718872,ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARMC7_NUP85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMC7_NUP85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARMC7KCTD13, CPSF6, APP, C2orf88, KRT31, TRIM27, TCF4, TNFAIP1, ABI2, IKZF1, RUNDC3A, IKZF3, ABI3, PAK7, CPSF7, CCDC33, EFHC2, SPATC1L, LZTS2, KRT40, SPERT, TRIM42, INCA1, ARMC7, CKAP4, RBM48, MPRIP, PHB, PHB2NUP85SEH1L, NUP107, NUP43, NUP37, SEC13, EEF1G, USP36, USP49, HDAC11, EGFR, FBXO6, DCTN3, GBF1, RABL6, OBSL1, EED, CCDC183, CD274, TNFSF13B, CA14, PNKD, ENPP6, TGOLN2, NUP160, NUP98, NTRK1, IFI16, PRKDC, UNC45A, FMN1, KPNB1, ZNF740, POM121, HSP90AB1, NUDC, NUP88, RANGAP1, NUP62, NUP214, RANBP2, NUP50, NUP153, B9D2, UBE2I, FOXQ1, FAF2, UXS1, VASN, CD70, SPAST, ZNF785


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARMC7_NUP85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARMC7_NUP85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource