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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2759

FusionGeneSummary for ARMC7_HN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7_HN1
Fusion gene ID: 2759
HgeneTgene
Gene symbol

ARMC7

HN1

Gene ID

79637

Gene namearmadillo repeat containing 7
Synonyms-
Cytomap

17q25.1

Type of geneprotein-coding
Descriptionarmadillo repeat-containing protein 7
Modification date20180519
UniProtAcc

Q9H6L4

Ensembl transtripts involved in fusion geneENST00000581078, ENST00000582136, 
ENST00000245543, ENST00000584947, 
ENST00000579096, 
ENST00000476258, 
ENST00000405458, ENST00000409753, 
ENST00000482348, ENST00000356033, 
ENST00000470924, ENST00000481647, 
ENST00000392566, ENST00000581874, 
ENST00000465454, 
Fusion gene scores* DoF score4 X 1 X 3=127 X 4 X 6=168
# samples 47
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND HN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-39-5028-01AARMC7chr17

73106701

+HN1chr17

73132345

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000581078ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3UTRENST00000581078ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-intronENST00000581078ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-3UTRENST00000582136ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000582136ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-3UTRENST00000245543ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000245543ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-3UTRENST00000584947ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000584947ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3UTRENST00000579096ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-intronENST00000579096ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-

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FusionProtFeatures for ARMC7_HN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC7

Q9H6L4

HN1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARMC7_HN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMC7_HN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARMC7KCTD13, CPSF6, APP, C2orf88, KRT31, TRIM27, TCF4, TNFAIP1, ABI2, IKZF1, RUNDC3A, IKZF3, ABI3, PAK7, CPSF7, CCDC33, EFHC2, SPATC1L, LZTS2, KRT40, SPERT, TRIM42, INCA1, ARMC7, CKAP4, RBM48, MPRIP, PHB, PHB2HN1ARHGAP44, SFPQ, KPNA2, CPLX1, PMPCB, SEPT9, UNK, CFL1, COTL1, HSPB1, PLIN3, SNCG, STMN1, TRIM28, CDH1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARMC7_HN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARMC7_HN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource