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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27546

FusionGeneSummary for PLD5_PLA2R1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLD5_PLA2R1
Fusion gene ID: 27546
HgeneTgene
Gene symbol

PLD5

PLA2R1

Gene ID

200150

22925

Gene namephospholipase D family member 5phospholipase A2 receptor 1
SynonymsPLDCCLEC13C|PLA2-R|PLA2G1R|PLA2IR|PLA2R
Cytomap

1q43

2q24.2

Type of geneprotein-codingprotein-coding
Descriptioninactive phospholipase D5inactive PLD 5inactive choline phosphatase 5inactive phosphatidylcholine-hydrolyzing phospholipase D5secretory phospholipase A2 receptor180 kDa secretory phospholipase A2 receptorC-type lectin domain family 13 member CM-type receptorphospholipase A2 receptor 1, 180kDphospholipase A2 receptor 1, 180kDa
Modification date2018040220180523
UniProtAcc

Q8N7P1

Q13018

Ensembl transtripts involved in fusion geneENST00000536534, ENST00000427495, 
ENST00000442594, ENST00000474177, 
ENST00000283243, ENST00000392771, 
ENST00000460710, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 5 X 4=60
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLD5 [Title/Abstract] AND PLA2R1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLA2R1

GO:0072593

reactive oxygen species metabolic process

19197340


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A197-06APLD5chr1

242687390

-PLA2R1chr2

160808089

-
TCGALDSKCMTCGA-ER-A197-06APLD5chr1

242687390

-PLA2R1chr2

160806287

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000536534ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160808089

-
Frame-shiftENST00000536534ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160808089

-
5CDS-intronENST00000536534ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-3CDSENST00000427495ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-3CDSENST00000427495ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-intronENST00000427495ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160808089

-
5UTR-3CDSENST00000442594ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160808089

-
5UTR-3CDSENST00000442594ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160808089

-
5UTR-intronENST00000442594ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-3CDSENST00000474177ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-3CDSENST00000474177ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160808089

-
intron-intronENST00000474177ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160808089

-
In-frameENST00000536534ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160806287

-
In-frameENST00000536534ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160806287

-
5CDS-intronENST00000536534ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-3CDSENST00000427495ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-3CDSENST00000427495ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-intronENST00000427495ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160806287

-
5UTR-3CDSENST00000442594ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160806287

-
5UTR-3CDSENST00000442594ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160806287

-
5UTR-intronENST00000442594ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-3CDSENST00000474177ENST00000283243PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-3CDSENST00000474177ENST00000392771PLD5chr1

242687390

-PLA2R1chr2

160806287

-
intron-intronENST00000474177ENST00000460710PLD5chr1

242687390

-PLA2R1chr2

160806287

-

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FusionProtFeatures for PLD5_PLA2R1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLD5

Q8N7P1

PLA2R1

Q13018

Receptor for secretory phospholipase A2 (sPLA2). Acts asa receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Althoughits precise function remains unclear, binding of sPLA2 to itsreceptor participates in both positive and negative regulation ofsPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type,such as activation of the mitogen-activated protein kinase (MAPK)cascade to induce cell proliferation, the production of lipidmediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1Bcan activate p38 MAPK to stimulate elastase release and celladhesion. May be involved in responses in proinflammatory cytokineproductions during endotoxic shock. Also has endocytic propertiesand rapidly internalizes sPLA2 ligands, which is particularlyimportant for the clearance of extracellular sPLA2s to protecttheir potent enzymatic activities. The soluble secretoryphospholipase A2 receptor form is circulating and acts as anegative regulator of sPLA2 functions by blocking the biologicalfunctions of sPLA2-IB/PLA2G1B. {ECO:0000269|PubMed:15611272,ECO:0000269|PubMed:7721806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-23301257_137811801464DomainC-type lectin 8
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-23271257_137811801325DomainC-type lectin 8
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-23301436_144211801464MotifNote=Endocytosis signal
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-23271436_144211801325MotifNote=Endocytosis signal
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-23301419_146311801464Topological domainCytoplasmic
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-23271419_146311801325Topological domainCytoplasmic
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-23301398_141811801464TransmembraneHelical
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-23271398_141811801325TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLD5chr1:242687390chr2:160806287ENST00000427495-110215_242-42475DomainNote=PLD phosphodiesterase 1
HgenePLD5chr1:242687390chr2:160806287ENST00000427495-110434_460-42475DomainNote=PLD phosphodiesterase 2
HgenePLD5chr1:242687390chr2:160806287ENST00000442594-211215_242-32445DomainNote=PLD phosphodiesterase 1
HgenePLD5chr1:242687390chr2:160806287ENST00000442594-211434_460-32445DomainNote=PLD phosphodiesterase 2
HgenePLD5chr1:242687390chr2:160806287ENST00000536534-110215_24263537DomainNote=PLD phosphodiesterase 1
HgenePLD5chr1:242687390chr2:160806287ENST00000536534-110434_46063537DomainNote=PLD phosphodiesterase 2
HgenePLD5chr1:242687390chr2:160806287ENST00000427495-11069_89-42475TransmembraneHelical
HgenePLD5chr1:242687390chr2:160806287ENST00000442594-21169_89-32445TransmembraneHelical
HgenePLD5chr1:242687390chr2:160806287ENST00000536534-11069_8963537TransmembraneHelical
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-23301121_123211801464DomainC-type lectin 7
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330173_22111801464DomainFibronectin type-II
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330238_35511801464DomainC-type lectin 1
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330385_50211801464DomainC-type lectin 2
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-233038_16111801464DomainRicin B-type lectin
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330522_64311801464DomainC-type lectin 3
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330673_79711801464DomainC-type lectin 4
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330819_93811801464DomainC-type lectin 5
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-2330965_109611801464DomainC-type lectin 6
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-23271121_123211801325DomainC-type lectin 7
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327173_22111801325DomainFibronectin type-II
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327238_35511801325DomainC-type lectin 1
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327385_50211801325DomainC-type lectin 2
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-232738_16111801325DomainRicin B-type lectin
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327522_64311801325DomainC-type lectin 3
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327673_79711801325DomainC-type lectin 4
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327819_93811801325DomainC-type lectin 5
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-2327965_109611801325DomainC-type lectin 6
TgenePLA2R1chr1:242687390chr2:160806287ENST00000283243-233021_139711801464Topological domainExtracellular
TgenePLA2R1chr1:242687390chr2:160806287ENST00000392771-232721_139711801325Topological domainExtracellular


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FusionGeneSequence for PLD5_PLA2R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000283243_chr2_160806287_-_347aa
MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHNGLNFDWSDGTKSSFTFWKDEESSLLG
DCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENA
FLLEELFAFGSSVQMVWLNAQFDGNNETIKWFDGTPTDQSNWGIRKPDTDYFKPHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAE

>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000392771_chr2_160806287_-_208aa
MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHNGLNFDWSDGTKSSFTFWKDEESSLLG
DCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000283243_chr2_160806287_-_1041nt
ATGGAGATCCGGCAGCACGAGTGGCTCTCGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCC
CCAAGCCTGACCCGAGTGGGCGCGAACTTCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAG
CTGGAGCACAATGGTCTTAATTTTGACTGGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGT
GACTGCGTTTTTGCCGACAGCAACGGACGCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAA
ACAAGACAATCTGAACACCCAGAGTTGTGCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTC
CTAGACAGTATGAGTTTTGAGGCTGCTCATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCA
TTTCTCCTAGAAGAGCTGTTTGCTTTTGGTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAATGAAACCATAAAG
TGGTTTGATGGAACTCCCACAGACCAGTCAAACTGGGGCATTCGGAAGCCAGACACAGACTACTTCAAGCCCCATCATTGTGTTGCCTTG
AGGATCCCTGAAGGATTATGGCAGCTATCCCCGTGTCAAGAAAAAAAAGGCTTTATATGTAAAATGGAGGCAGATATTCACACTGCAGAG
GCGCTGCCAGAAAAAGGACCAAGTCACAGCATCATTCCTCTTGCGGTTGTACTGACACTGATAGTCATTGTGGCCATTTGCACACTTTCC
TTCTGCATATACAAGCATAACGGTGGCTTCTTCAGGAGACTTGCAGGGTTTCGGAATCCTTACTATCCTGCAACCAACTTTAGTACAGTA

>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000392771_chr2_160806287_-_624nt
ATGGAGATCCGGCAGCACGAGTGGCTCTCGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCC
CCAAGCCTGACCCGAGTGGGCGCGAACTTCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAG
CTGGAGCACAATGGTCTTAATTTTGACTGGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGT
GACTGCGTTTTTGCCGACAGCAACGGACGCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAA
ACAAGACAATCTGAACACCCAGAGTTGTGCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTC
CTAGACAGTATGAGTTTTGAGGCTGCTCATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000283243_chr2_160806287_-_5210nt
CACCTCGCCCTCCCTCCTTCCGCCCCGCGCCTCCCGCGATCGCCCCCTCCCGCCCGGCCGCGCTCCCAGCTGGCGCTCAGCACCCCGCGC
TCCCCGCGCCCGCTCGCTCCTCCAGCTCCTCCAGCTCAGTCTCCAGCTCCACCTCCGGCTCCCGCTGGGCCTCCCGCTCGCCCTCCGCGC
CCGGCTCCCCGCGCGCCCGTCCCGAGTCCGCTGCTCGCCGGCGGCCGCCCGGTCATGTCAGGATGGAGATCCGGCAGCACGAGTGGCTCT
CGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCCCCAAGCCTGACCCGAGTGGGCGCGAACT
TCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAGCTGGAGCACAATGGTCTTAATTTTGACT
GGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGTGACTGCGTTTTTGCCGACAGCAACGGAC
GCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAAACAAGACAATCTGAACACCCAGAGTTGT
GCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTCCTAGACAGTATGAGTTTTGAGGCTGCTC
ATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCATTTCTCCTAGAAGAGCTGTTTGCTTTTG
GTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAATGAAACCATAAAGTGGTTTGATGGAACTCCCACAGACCAGT
CAAACTGGGGCATTCGGAAGCCAGACACAGACTACTTCAAGCCCCATCATTGTGTTGCCTTGAGGATCCCTGAAGGATTATGGCAGCTAT
CCCCGTGTCAAGAAAAAAAAGGCTTTATATGTAAAATGGAGGCAGATATTCACACTGCAGAGGCGCTGCCAGAAAAAGGACCAAGTCACA
GCATCATTCCTCTTGCGGTTGTACTGACACTGATAGTCATTGTGGCCATTTGCACACTTTCCTTCTGCATATACAAGCATAACGGTGGCT
TCTTCAGGAGACTTGCAGGGTTTCGGAATCCTTACTATCCTGCAACCAACTTTAGTACAGTATATTTAGAAGAAAATATTCTCATTTCTG
ATCTTGAGAAGAGTGACCAATAATAATGAGGTCAGAGAATGCCACAGACACCAGGGTAAGTAAAGAAGACTAAACAGGAGTCTCATCTGT
CTTTCCCTTTACAGCACAGATGCCATTAGAATGTGAATTGGGTCACTATTTTAATTATTCTTGAAGTGATTACTGGTTTTGAATCTTAAC
CAAATCAGATGGGTTTTGATTTATTCATTTCCCTAAACTGTGATCCATTCTTAAAAGGGGTAAATTATGCATTGGTTATTTTTCAGAAAG
ACAAGAACTATTAAAAGAAACTCCCTATTGAAAACTCTGAAATCAATGCGAATAATAGTTTTTGCATTAATGTATCTCTACTAAAATTTG
GGGGAATTTTAAAACTAATCTGGTATCTATTCAGACATTTACCTGCACTCGTACCATTAAGAAAGACAGAAAGAAGCAAAAAAAAATTAA
TCTTGTATATGAGAGGAAAAGGAAAGGGCTTCTGAGAGGATTCTTAGTTGTTTCTTTTGAATTCACTTTTAATAGCAGGATTTGGAAAAT
ACTAATTTCTGTGCTTAAGGGTCACAGGTTCTGGGCTCTCAACTGATATTTAAGGTGACATTCATTTTTATTAGGTCTAACATCTCAAGC
TAAAGGAGAAAGAAAAATACCTTCTTTTAAATGGCAAAGACCTTCATTAGCAGCACACTTTTATAAACAACCATATAGTTAAAATGTGGC
CTTAAACTTTCAATTACTAAATGATGATTAAGTTGGATATTTTAAAATGTCTTATACATAAGCTTAAAGTAATATATTGAAACTTTAACA
GTTGTACTGTTAAAACTCATGGACTTTCTGAAAAACTAAATATATAAAATAATATGTAACACTCTTAATAACTGGAAGATATAAAATGTA
ACTTGGATTTAAAGGAGAAGAGCTAAAGATCTGAATTATAGTCTCATTAGAACCAGACAGATGTTGTTGAGAAGTACTAAATAAATTAGT
AATCTAGATATCTTTATTATGTAAATGAGTTTAGGTGTTCTATTTAATAAACTATTTTCTGGGAACGATCTCCTTTTATATTAGTCTAGT
TAGTGTAGATGGTAAATAATGATTATGATACTGTCTGTAAATAAAAAATTACAGATTTTATTTTCCTTTATTAGTTCCTTATAAAGAAAA
CAGCTTCATAATCAATATCTAAAAATTTACTCATTACATAACTGTTTATTGAATTTTATCAAGAAAAAAGTGTACTGAGCATGGTGGCAC
GCACCTGTAGTCCCAGCTACTTAGGAGGCTGAGGGAAGAGGATCAACTGAGCCCAGAAGTTGAAGGCTGCAGTGAGCTATGGTTGCACCA
CTGCACTCCTGCCTGGGCAACTGAATGAGACCCCACCTCAAAAAAGTGCTGTTCTAGAAACAGAGGTACTAAGGTGAGCAACTTGGGGTA
AGGGCTATCTTTTCATGCCACTTATTTTCTAATGAGGGAAAATTGACAGTAACTCAGTAAAGAAATGCATATGCATAAAATAGCAAGTGG
TTATGAAAATGAAGTAAGGTTCCATGATAGAGAGAAACTGGGGGACTCTCAGGGCCTCCCTGAGAGTGTGCATTTTAATTATTACAACCA
ACTGCCTCAAAACCAGTGGCCACTAATCACAAGGGGGAGCTCTGAGAGAAAGTATGAATGAATTTCTAAGAGGCAAACCATCATCATTAG
AAATACAATTTGAAGAGCATACCACTAAGAATGGAATCCTTGTGGCCTGCAACAGTTAATCCAGCTTCCAAAAGCAGCTCTTTGCTACTG
TTATAATAATTTACACACTGGGACAGTCTACCTCCATAATTTTTTTAAGTATTGGGACTTCATTTTTTAAAAGATATTATATTATGTGGC
AGTTGCATATTTATGACTCAAAAAATAATTGGCTTGAACTCACCAGATGGTATAAAAGCCCAATTTAACCATCTTTTGAGTGGAATTAAA
GTTCTGTTCTTTTCAATGGACTTGGTAAAAACTGCTAATCAACCAGCCTTCCAGTCAAGGTATATAGTCACACATAATAATTTGACAAAA
TACACCATTAGGAAAGTGATTTTGCAGAAAGAAGCTGTATTGCTTCTCAGTGCTCCATACTTTGATGTTTAGTATTGAACAACATCTCCA
GATAATCTGGACCCATGGACAGATCACACACTTCTTGCCATTACTGAATTTGCAGAAATAGTACTGAAGTATTCTGCTACATTTTTATAT
TTGCATTTTTTTTGAAACTTTTTTTCATTTTTTTTTTTTTTTTTTGGAGATGGAGTCTTGCTCTGTTGCCAGGCAGGAGTACAGTGGCAT
GATCTCAGCTCACTGCAACCTTCAACTGCCTGGTTCGAGCAAGTTTCCTGCCTCAGCCTCCCGAGTAGCTGTGATTACAGGCACATGCCA
CCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGATGGTCTCGATCTCCTGATCTCGTGATCCAC
CCGCCCCAGCCTCCCAAAGTGCTAAGATTACAGGCATGAGCCACCGCACCTGGCCTCATCTGTATTTTTAATGTGAACTAGATTTTATAG
CTATAATTCGAAAAGAAAAAAAAGTAGCAGGTAATGGGTATATTATACACTATTTGCGTGATGGTTACACCAGACTTTACCACTACATAC
TGTATTTATGTAACAAAATTACACTTGTACTCCTTACATTTATGCCAAAAAAGCGGCAGGATCACAAATTCACACATAGTTAATGTGCCC
CTCCAACAGTCAATTATGTTCTATGACTAACCTGAGGATCTTTATAGAATCTGAGTAATGGAAATGCCTGGGTTTTTCCATTTAACAATA
TATTGGGCTCTTACAGTTACAACAGTCTTCTTTCGGGTTAAATATTTCTTCTCTTGAAGGGTCCACTCCTTATTAAAGATAAGATTGAAC
TGAATGTTTACTTAAACGTTCAGTCTTTTGGAGTTTCTTTACTCTTCTCAAAATGGTGGTTGGATATATAAGAACTTGCTGTGTCCTGGT
AGTGTTGAGGGGAGAAGGTGACAACTTACTGTGGATGTATGTTAGCTGGTGTCCACTGAGAATAGCTGTCTGGCCTCACTCCTGGGAATT
CTGCTGGCATCTGCTGTGAAGTCTGCAGTTGCTTTAATCTGTAGTCTGTTCTCTTTGATTTGGCCTCATTCTGGCTGTCCCTGGTGCTGT
CTTATCTCTTGAGAACTGGCTGTGTCTCCTGTTGAATTCCCTATCCGAACACTGCAGTTCTTGGCTACAAGGCAGTCACTTCACCCCTGC
AGTGGTGAGATCCCATTAGCTACCATTAGCTACTCTTTTCGTCCAGAAAGGCGAAATGCCATAGCAAACAATCCCACAGTCTTGGTGGAT
TAACACAGCAAAGGTTTATTTCTCACCCACACCTGCATGGGCTGGCAAGAGGACTTTGCTCTGTTCAGTCATTCATGGGTCCATGCTTCT
CCTATATAGCCAGCCCTCTGTCTCCTAAGGCCTGGAGTCCTCCATGGGCCTCCAATCTGTGGCTGACAGAGGATGTTGACTTGAGACCCA
TCTTTGATTCATTATGGAGCTTCCACAGGCTGTTGAAATCCTCTAAGTCAAAAGTCCTCAAACTGGGGACACATGCCTAAGGAATACAGG
AGCATGGGTATTTAAGAAACTTAATTTCCAGAATCTTCATGTATATTTTTTCTTAAAACTGATTTACCTGAGAGCACCCCTGGTTCTTCT
TTCCCACCTCTCTTTACACAAATGCCTTTCTCTACCTTTAAAAAGAAAAAGAAAAAGAAATGGCTTTCATTTCAGATCTTACTATGGGAA

>In-frame_PLD5_ENST00000536534_chr1_242687390_-_PLA2R1_ENST00000392771_chr2_160806287_-_1844nt
CACCTCGCCCTCCCTCCTTCCGCCCCGCGCCTCCCGCGATCGCCCCCTCCCGCCCGGCCGCGCTCCCAGCTGGCGCTCAGCACCCCGCGC
TCCCCGCGCCCGCTCGCTCCTCCAGCTCCTCCAGCTCAGTCTCCAGCTCCACCTCCGGCTCCCGCTGGGCCTCCCGCTCGCCCTCCGCGC
CCGGCTCCCCGCGCGCCCGTCCCGAGTCCGCTGCTCGCCGGCGGCCGCCCGGTCATGTCAGGATGGAGATCCGGCAGCACGAGTGGCTCT
CGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCCCCAAGCCTGACCCGAGTGGGCGCGAACT
TCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAGCTGGAGCACAATGGTCTTAATTTTGACT
GGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGTGACTGCGTTTTTGCCGACAGCAACGGAC
GCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAAACAAGACAATCTGAACACCCAGAGTTGT
GCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTCCTAGACAGTATGAGTTTTGAGGCTGCTC
ATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCATTTCTCCTAGAAGAGCTGTTTGCTTTTG
GTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAGTAAGTGATTTGGGTAGAGGAGAGGACATAAATAAATACATG
GTTGTTAAAGCTGATGATAATGGCATCTGTGAGCCAGAAAACTCTCCTTGGATACGTTTTCTGAGAAAAAATAGCATGAAGCCTAAAGCC
ATTTCTTCCAAAAACAACATTGCAACCCTTTTCTTTACCCTTTTGTCTTTTAAAATAATCCCAGAACACCAAAAATAAAAACAAACAATA
ACATGTTTATCTTTACCCTTAGCAGGAAGATGCTTGGCTGGAACTTTGTGTTCACAGACTTAGTCATTGCATACCAAAACCATATTTACT
GGAAAATATCCCAGGTTTCTAAATGTTATAAAAGCACAATAGAGTTATGGAAATGTTTCCATGATGAACTGTGCTGTTAGGATTCTTATT
TGCTACTCATAAAAACCAGAGTTTGTAATAAAATGGAAGCATGGTATTCTTTTCTTTATGTAATTGATGGTTATTGAAAGGTACTTGTGA
AGAAAATTATTTTAATTGGTATGGAGAGCTTGTTACAGTGGTGTACCAAGGTTGGGGGTGAGCCTACCCTTTCGAGGAGGAGTATTTTAA
TCACCAACATTGTTTAGAATTTCAAGCAGATGGTGATAATAAAAAGCAGACCAACTTTTAGTTAGCTGTATTGTTAGTTTTAAATTATTT
TCAGACAATACACTATTGCCCACACATGGGATGGACTCTCCTACCGCCCCTACCCCCTTGGTACATGGCTGGCTTGGTATTAAAGAAATT
CACTGTAAAATCTTTTTAGAAAGTGAGCCATTTTGTAATGATGAAGATGTTAGGACTTCAAAGGATTTTTCTTTACTCGATTAGTTTTGT
TTATCAAATGATTTCTTTAAATCGATTATATATATATATGGAATATTTCAAAATTCAAACTGTCACATTAAGAAACATGATAACCTAAAT


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FusionGenePPI for PLD5_PLA2R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLD5PLA2R1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLD5_PLA2R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLD5_PLA2R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLD5C0004352Autistic Disorder1CTD_human
TgenePLA2R1C0236969Substance-Related Disorders1CTD_human