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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27545

FusionGeneSummary for PLD5_NAMPT

check button Fusion gene summary
Fusion gene informationFusion gene name: PLD5_NAMPT
Fusion gene ID: 27545
HgeneTgene
Gene symbol

PLD5

NAMPT

Gene ID

200150

10135

Gene namephospholipase D family member 5nicotinamide phosphoribosyltransferase
SynonymsPLDC1110035O14Rik|PBEF|PBEF1|VF|VISFATIN
Cytomap

1q43

7q22.3

Type of geneprotein-codingprotein-coding
Descriptioninactive phospholipase D5inactive PLD 5inactive choline phosphatase 5inactive phosphatidylcholine-hydrolyzing phospholipase D5nicotinamide phosphoribosyltransferaseNAmPRTasepre-B cell-enhancing factorpre-B-cell colony-enhancing factor 1
Modification date2018040220180519
UniProtAcc

Q8N7P1

P43490

Ensembl transtripts involved in fusion geneENST00000536534, ENST00000427495, 
ENST00000442594, ENST00000474177, 
ENST00000222553, ENST00000354289, 
ENST00000484527, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 2=50
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: PLD5 [Title/Abstract] AND NAMPT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAMPT

GO:0008286

insulin receptor signaling pathway

17983582

TgeneNAMPT

GO:0045944

positive regulation of transcription by RNA polymerase II

23001182

TgeneNAMPT

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

19727662

TgeneNAMPT

GO:0060612

adipose tissue development

17983582


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ335321PLD5chr1

242370111

-NAMPTchr7

105925393

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000536534ENST00000222553PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000536534ENST00000354289PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000536534ENST00000484527PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-5UTRENST00000427495ENST00000222553PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000427495ENST00000354289PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000427495ENST00000484527PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-5UTRENST00000442594ENST00000222553PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000442594ENST00000354289PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000442594ENST00000484527PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-5UTRENST00000474177ENST00000222553PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000474177ENST00000354289PLD5chr1

242370111

-NAMPTchr7

105925393

-
intron-intronENST00000474177ENST00000484527PLD5chr1

242370111

-NAMPTchr7

105925393

-

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FusionProtFeatures for PLD5_NAMPT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLD5

Q8N7P1

NAMPT

P43490

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamidemononucleotide, an intermediate in the biosynthesis of NAD. It isthe rate limiting component in the mammalian NAD biosynthesispathway. The secreted form behaves both as a cytokine withimmunomodulating properties and an adipokine with anti-diabeticproperties, it has no enzymatic activity, partly because of lackof activation by ATP, which has a low level in extracellular spaceand plasma. Plays a role in the modulation of circadian clockfunction. NAMPT-dependent oscillatory production of NAD regulatesoscillation of clock target gene expression by releasing the coreclock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependentSIRT1-mediated suppression (By similarity).{ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLD5_NAMPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLD5_NAMPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLD5_NAMPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLD5_NAMPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLD5C0004352Autistic Disorder1CTD_human
TgeneNAMPTC0009319Colitis1CTD_human
TgeneNAMPTC0009404Colorectal Neoplasms1CTD_human
TgeneNAMPTC0028754Obesity1CTD_human
TgeneNAMPTC0162820Dermatitis, Allergic Contact1CTD_human