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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27542

FusionGeneSummary for PLD3_PLD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PLD3_PLD3
Fusion gene ID: 27542
HgeneTgene
Gene symbol

PLD3

PLD3

Gene ID

23646

23646

Gene namephospholipase D family member 3phospholipase D family member 3
SynonymsAD19|HU-K4|HUK4|SCA46AD19|HU-K4|HUK4|SCA46
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipase D3choline phosphatase 3hindIII K4L homologphosphatidylcholine-hydrolyzing phospholipase D3phospholipase D3choline phosphatase 3hindIII K4L homologphosphatidylcholine-hydrolyzing phospholipase D3
Modification date2018051920180519
UniProtAcc

Q8IV08

Q8IV08

Ensembl transtripts involved in fusion geneENST00000409419, ENST00000409587, 
ENST00000594085, ENST00000409735, 
ENST00000356508, ENST00000409281, 
ENST00000409419, ENST00000409587, 
ENST00000594085, ENST00000409735, 
ENST00000356508, ENST00000409281, 
Fusion gene scores* DoF score10 X 9 X 5=4503 X 4 X 2=24
# samples 114
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLD3 [Title/Abstract] AND PLD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL041531PLD3chr19

40880484

-PLD3chr19

40882531

+
ChiTaRS3.1CA310232PLD3chr19

40884213

-PLD3chr19

40871778

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409419ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409419ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409419ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409419ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409419ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409419ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409587ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409587ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409587ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409587ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409587ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409587ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-3CDSENST00000594085ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-3CDSENST00000594085ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-intronENST00000594085ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-intronENST00000594085ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-intronENST00000594085ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
intron-intronENST00000594085ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409735ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409735ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409735ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409735ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409735ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409735ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000356508ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000356508ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000356508ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000356508ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000356508ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000356508ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409281ENST00000409419PLD3chr19

40880484

-PLD3chr19

40882531

+
In-frameENST00000409281ENST00000409587PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409281ENST00000594085PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409281ENST00000409735PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409281ENST00000356508PLD3chr19

40880484

-PLD3chr19

40882531

+
5CDS-intronENST00000409281ENST00000409281PLD3chr19

40880484

-PLD3chr19

40882531

+
3UTR-intronENST00000409419ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409419ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-3UTRENST00000409419ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409419ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409419ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409419ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409587ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409587ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-3UTRENST00000409587ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409587ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409587ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409587ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-intronENST00000594085ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-5UTRENST00000594085ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-3UTRENST00000594085ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-5UTRENST00000594085ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-intronENST00000594085ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
intron-5UTRENST00000594085ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409735ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409735ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-3UTRENST00000409735ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409735ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409735ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409735ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000356508ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000356508ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-3UTRENST00000356508ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000356508ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000356508ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000356508ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409281ENST00000409419PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409281ENST00000409587PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-3UTRENST00000409281ENST00000594085PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409281ENST00000409735PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-intronENST00000409281ENST00000356508PLD3chr19

40884213

-PLD3chr19

40871778

+
3UTR-5UTRENST00000409281ENST00000409281PLD3chr19

40884213

-PLD3chr19

40871778

+

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FusionProtFeatures for PLD3_PLD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLD3

Q8IV08

PLD3

Q8IV08

May be involved in APP processing.{ECO:0000305|PubMed:24336208}. May be involved in APP processing.{ECO:0000305|PubMed:24336208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLD3_PLD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLD3_PLD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLD3_PLD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLD3_PLD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource