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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27538

FusionGeneSummary for PLD3_CPNE5

check button Fusion gene summary
Fusion gene informationFusion gene name: PLD3_CPNE5
Fusion gene ID: 27538
HgeneTgene
Gene symbol

PLD3

CPNE5

Gene ID

23646

57699

Gene namephospholipase D family member 3copine 5
SynonymsAD19|HU-K4|HUK4|SCA46COPN5|CPN5
Cytomap

19q13.2

6p21.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipase D3choline phosphatase 3hindIII K4L homologphosphatidylcholine-hydrolyzing phospholipase D3copine-5copine V
Modification date2018051920180523
UniProtAcc

Q8IV08

Q9HCH3

Ensembl transtripts involved in fusion geneENST00000409419, ENST00000409587, 
ENST00000594085, ENST00000409735, 
ENST00000356508, ENST00000409281, 
ENST00000459703, ENST00000393189, 
ENST00000244751, 
Fusion gene scores* DoF score10 X 9 X 5=4504 X 4 X 3=48
# samples 114
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLD3 [Title/Abstract] AND CPNE5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPNE5

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE699806PLD3chr19

40882570

+CPNE5chr6

36790319

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409419ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409419ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409419ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409587ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409587ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409587ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-
intron-intronENST00000594085ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
intron-intronENST00000594085ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
intron-intronENST00000594085ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409735ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409735ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409735ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000356508ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000356508ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000356508ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409281ENST00000459703PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409281ENST00000393189PLD3chr19

40882570

+CPNE5chr6

36790319

-
5CDS-intronENST00000409281ENST00000244751PLD3chr19

40882570

+CPNE5chr6

36790319

-

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FusionProtFeatures for PLD3_CPNE5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLD3

Q8IV08

CPNE5

Q9HCH3

May be involved in APP processing.{ECO:0000305|PubMed:24336208}. Probable calcium-dependent phospholipid-binding proteinthat may play a role in calcium-mediated intracellular processes(By similarity). Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000250|UniProtKB:Q99829,ECO:0000269|PubMed:23999003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLD3_CPNE5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLD3_CPNE5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLD3_CPNE5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLD3_CPNE5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource