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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27528

FusionGeneSummary for PLD1_FNDC3B

check button Fusion gene summary
Fusion gene informationFusion gene name: PLD1_FNDC3B
Fusion gene ID: 27528
HgeneTgene
Gene symbol

PLD1

FNDC3B

Gene ID

5589

64778

Gene nameprotein kinase C substrate 80K-Hfibronectin type III domain containing 3B
SynonymsAGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60FAD104|PRO4979|YVTM2421
Cytomap

19p13.2

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionglucosidase 2 subunit betaAGE-binding receptor 2advanced glycation end-product receptor 2glucosidase II subunit betahepatocystinprotein kinase C substrate 60.1 kDa protein heavy chainprotein kinase C substrate, 80 Kda proteinfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104
Modification date2018052220180519
UniProtAcc

Q13393

Q53EP0

Ensembl transtripts involved in fusion geneENST00000356327, ENST00000351298, 
ENST00000342215, ENST00000340989, 
ENST00000497307, 		ENST00000415807, 
ENST00000336824, ENST00000416957, 
ENST00000392699, ENST00000421757, 
ENST00000423424, ENST00000476794, 
Fusion gene scores* DoF score5 X 4 X 4=8011 X 13 X 5=715
# samples 514
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/715*10)=-2.35251641472079
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLD1 [Title/Abstract] AND FNDC3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-63-A5MP-01APLD1chr3

171528189

-FNDC3Bchr3

171830242

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000356327ENST00000415807PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000356327ENST00000336824PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000356327ENST00000416957PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000356327ENST00000392699PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000356327ENST00000421757PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000356327ENST00000423424PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-intronENST00000356327ENST00000476794PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000415807PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000336824PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000416957PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000392699PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000421757PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000351298ENST00000423424PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-intronENST00000351298ENST00000476794PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000415807PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000336824PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000416957PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000392699PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000421757PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000342215ENST00000423424PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-intronENST00000342215ENST00000476794PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000415807PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000336824PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000416957PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000392699PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000421757PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000340989ENST00000423424PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-intronENST00000340989ENST00000476794PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000415807PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000336824PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000416957PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000392699PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000421757PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-5UTRENST00000497307ENST00000423424PLD1chr3

171528189

-FNDC3Bchr3

171830242

+
5UTR-intronENST00000497307ENST00000476794PLD1chr3

171528189

-FNDC3Bchr3

171830242

+

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FusionProtFeatures for PLD1_FNDC3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLD1

Q13393

FNDC3B

Q53EP0

Implicated as a critical step in numerous cellularpathways, including signal transduction, membrane trafficking, andthe regulation of mitosis. May be involved in the regulation ofperinuclear intravesicular membrane traffic (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLD1_FNDC3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLD1_FNDC3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLD1PRKCA, SRC, RHOA, AMPH, BIN1, SNCA, PEA15, PKN1, RALA, ARF1, ARF6, CDC42, PLCG2, ACTG1, RHEB, HIF1A, EGLN1, VHL, KCTD17, SPACA1, TEX264, ZRANB2, MIER2, C1orf186, POLH, CEP135, ATP6AP2, ING3, GPR156, CACNG5, UBE2O, CDH5, TNFRSF19, OSBPL5, C5AR2, APBA2FNDC3BELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLD1_FNDC3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLD1Q13393DB00122CholinePhospholipase D1small moleculeapproved|nutraceutical

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RelatedDiseases for PLD1_FNDC3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLD1C0018800Cardiomegaly1CTD_human
HgenePLD1C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneFNDC3BC0022578Keratoconus1CTD_human
TgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human