FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27516

FusionGeneSummary for PLCH1_SERPINA5

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCH1_SERPINA5
Fusion gene ID: 27516
HgeneTgene
Gene symbol

PLCH1

SERPINA5

Gene ID

23007

5104

Gene namephospholipase C eta 1serpin family A member 5
SynonymsPLCL3PAI-3|PAI3|PCI|PCI-B|PLANH3|PROCI
Cytomap

3q25.31

14q32.13

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1PLC eta 1PLC-L3phosphoinositide phospholipase C-eta-1phospholipase C-eta1aphospholipase C-eta1bphospholipase C-like 3phospholipase C-like protein 3plasma serine protease inhibitoracrosomal serine protease inhibitorplasminogen activator inhibitor IIIplasminogen activator inhibitor-3protein C inhibitorserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member
Modification date2018051920180523
UniProtAcc

Q4KWH8

P05154

Ensembl transtripts involved in fusion geneENST00000494598, ENST00000460012, 
ENST00000447496, ENST00000340059, 
ENST00000414191, ENST00000334686, 
ENST00000553780, ENST00000554866, 
ENST00000329597, ENST00000554276, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 4 X 1=16
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLCH1 [Title/Abstract] AND SERPINA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLCH1

GO:0048015

phosphatidylinositol-mediated signaling

15702972


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB035358PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000494598ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000494598ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000494598ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000494598ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000460012ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000460012ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000460012ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000460012ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000447496ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000447496ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000447496ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000447496ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000340059ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000340059ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000340059ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000340059ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000414191ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000414191ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000414191ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000414191ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000334686ENST00000553780PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000334686ENST00000554866PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-5UTRENST00000334686ENST00000329597PLCH1chr3

155393829

-SERPINA5chr14

95047806

+
intron-intronENST00000334686ENST00000554276PLCH1chr3

155393829

-SERPINA5chr14

95047806

+

Top

FusionProtFeatures for PLCH1_SERPINA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLCH1

Q4KWH8

SERPINA5

P05154

The production of the second messenger moleculesdiacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ismediated by calcium-activated phosphatidylinositol-specificphospholipase C enzymes. {ECO:0000269|PubMed:15702972}. Heparin-dependent serine protease inhibitor acting inbody fluids and secretions. Inactivates serine proteases bybinding irreversibly to their serine activation site. Involved inthe regulation of intravascular and extravascular proteolyticactivities. Plays hemostatic roles in the blood plasma. Acts as aprocoagulant and proinflammatory factor by inhibiting theanticoagulant activated protein C factor as well as the generationof activated protein C factor by the thrombin/thrombomodulincomplex. Acts as an anticoagulant factor by inhibiting bloodcoagulation factors like prothrombin, factor XI, factor Xa, plasmakallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivatesseveral serine proteases implicated in the reproductive system.Inhibits the serpin acrosin; indirectly protects component of themale genital tract from being degraded by excessive releasedacrosin. Inhibits tissue-and urinary-type plasminogen activator,prostate-specific antigen and kallikrein activities; has a controlon the sperm motility and fertilization. Inhibits the activatedprotein C-catalyzed degradation of SEMG1 and SEMG2; regulates thedegradation of semenogelin during the process of transfer ofspermatozoa from the male reproductive tract into the femaletract. In urine, inhibits urinary-type plasminogen activator andkallikrein activities. Inactivates membrane-anchored serineproteases activities such as MPRSS7 and TMPRSS11E. Inhibitsurinary-type plasminogen activator-dependent tumor cell invasionand metastasis. May also play a non-inhibitory role in seminalplasma and urine as a hydrophobic hormone carrier by its bindingto retinoic acid. {ECO:0000269|PubMed:10340997,ECO:0000269|PubMed:11722589, ECO:0000269|PubMed:14696115,ECO:0000269|PubMed:15140131, ECO:0000269|PubMed:15328353,ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:1725227,ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:2844223,ECO:0000269|PubMed:3501295, ECO:0000269|PubMed:6323392,ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:7548057,ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:8665956,ECO:0000269|PubMed:9473218, ECO:0000269|PubMed:9510955,ECO:0000269|PubMed:9556620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PLCH1_SERPINA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PLCH1_SERPINA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PLCH1_SERPINA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSERPINA5P05154DB00013UrokinasePlasma serine protease inhibitorbiotechapproved|investigational|withdrawn
TgeneSERPINA5P05154DB00055Drotrecogin alfaPlasma serine protease inhibitorbiotechapproved|investigational|withdrawn

Top

RelatedDiseases for PLCH1_SERPINA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSERPINA5C0236733Amphetamine-Related Disorders1CTD_human