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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 27499

FusionGeneSummary for PLCB4_MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCB4_MACROD2
Fusion gene ID: 27499
HgeneTgene
Gene symbol

PLCB4

MACROD2

Gene ID

5332

140733

Gene namephospholipase C beta 4MACRO domain containing 2
SynonymsARCND2|PI-PLCC20orf133|C2orf133
Cytomap

20p12.3-p12.2

20p12.1

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-41-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-beta-4dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))inositoltrisphosphohydrolaseO-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolase
Modification date2018051920180519
UniProtAcc

Q15147

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000334005, ENST00000378473, 
ENST00000278655, ENST00000414679, 
ENST00000492632, ENST00000378501, 
ENST00000378493, 		ENST00000217246, 
ENST00000310348, ENST00000464883, 
ENST00000402914, ENST00000378058, 
ENST00000407045, 
Fusion gene scores* DoF score6 X 6 X 5=18019 X 14 X 11=2926
# samples 619
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2926*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLCB4 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A7D5-01APLCB4chr20

9288545

+MACROD2chr20

15843390

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000334005ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000334005ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000334005ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000334005ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000334005ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000334005ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378473ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378473ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378473ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000378473ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378473ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378473ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000278655ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000278655ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000278655ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000278655ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000278655ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000278655ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000414679ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000414679ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000414679ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000414679ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000414679ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000414679ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-3CDSENST00000492632ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-3CDSENST00000492632ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-intronENST00000492632ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-5UTRENST00000492632ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-intronENST00000492632ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
3UTR-intronENST00000492632ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378501ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378501ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378501ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000378501ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378501ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378501ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378493ENST00000217246PLCB4chr20

9288545

+MACROD2chr20

15843390

+
In-frameENST00000378493ENST00000310348PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378493ENST00000464883PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000378493ENST00000402914PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378493ENST00000378058PLCB4chr20

9288545

+MACROD2chr20

15843390

+
5CDS-intronENST00000378493ENST00000407045PLCB4chr20

9288545

+MACROD2chr20

15843390

+

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FusionProtFeatures for PLCB4_MACROD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLCB4

Q15147

MACROD2

A1Z1Q3

Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+717247_388215426Compositional biasNote=Glu-rich
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+718247_388215449Compositional biasNote=Glu-rich
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+010247_3880214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+0106_90214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+314247_388-20214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+3146_9-20214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+06247_388-7999Compositional biasNote=Glu-rich
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+066_9-7999Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+01059_2400214DomainMacro
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+31459_240-20214DomainMacro
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+0659_240-7999DomainMacro
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+010185_1910214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+01077_790214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+01090_920214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000378058+01097_1020214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+314185_191-20214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+31477_79-20214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+31490_92-20214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000402914+31497_102-20214RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+06185_191-7999RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+0677_79-7999RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+0690_92-7999RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000407045+0697_102-7999RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCB4chr20:9288545chr20:15843390ENST00000278655+236313_463281176DomainPI-PLC X-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000278655+236565_681281176DomainPI-PLC Y-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000278655+236688_786281176DomainC2
HgenePLCB4chr20:9288545chr20:15843390ENST00000334005+338313_463281195DomainPI-PLC X-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000334005+338565_681281195DomainPI-PLC Y-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000334005+338688_786281195DomainC2
HgenePLCB4chr20:9288545chr20:15843390ENST00000378493+135313_463281176DomainPI-PLC X-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000378493+135565_681281176DomainPI-PLC Y-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000378493+135688_786281176DomainC2
HgenePLCB4chr20:9288545chr20:15843390ENST00000378501+136313_463281195DomainPI-PLC X-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000378501+136565_681281195DomainPI-PLC Y-box
HgenePLCB4chr20:9288545chr20:15843390ENST00000378501+136688_786281195DomainC2
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+7176_9215426Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+7186_9215449Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+71759_240215426DomainMacro
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+71859_240215449DomainMacro
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+717185_191215426RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+71777_79215426RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+71790_92215426RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000217246+71797_102215426RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+718185_191215449RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+71877_79215449RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+71890_92215449RegionNote=Substrate binding
TgeneMACROD2chr20:9288545chr20:15843390ENST00000310348+71897_102215449RegionNote=Substrate binding


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FusionGeneSequence for PLCB4_MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_239aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_262aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ
DADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_717nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_786nt
ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGAT
CGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAA
GAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAA
GATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGAT
GAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAAT
GAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAA
CCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGT
GAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4269nt
AGTAAGTGAGCTGCACCGCCAACAAGATCTCTCACACACAGACACACACACGCACACGCACACACGGGCGCGCACACACACGCGCGTACA
CACTGGGTCTCCAGGCAGCGGCCGTCGCCGCATCCCCGGCAGCAGCTCCAGGCAAAGTGACAGAGGACAGTGCTGCTGTGAGTTTGACGA
AGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTT
CCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAA
ATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAG
AACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCT
GCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCT
GTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATG
GAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAA
GAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGC
TCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATT
TCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCAT
GTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTC
ACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAG
TGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGG
CAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTG
GCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCT
TCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACT
ACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCA
TTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCA
AGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAA
TGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAA
GGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAAT
ATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACAT
ATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGA
GAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATG
GAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAG
TTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGAC
CTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTT
TCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTA
TAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTT
AGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAG
AGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATT
TATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGG
AAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTG
CTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATA
TTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAA
ATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGA
GTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATT
AAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGAT
TACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAA
AAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTG
AAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCC
TGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTT
GCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAA
TGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGC

>In-frame_PLCB4_ENST00000334005_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_1017nt
AGTAAGTGAGCTGCACCGCCAACAAGATCTCTCACACACAGACACACACACGCACACGCACACACGGGCGCGCACACACACGCGCGTACA
CACTGGGTCTCCAGGCAGCGGCCGTCGCCGCATCCCCGGCAGCAGCTCCAGGCAAAGTGACAGAGGACAGTGCTGCTGTGAGTTTGACGA
AGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTT
CCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAA
ATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAG
AACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCT
GCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCT
GTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATG
GAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAA
GAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCG

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4269nt
AGTAAGTGAGCTGCACCGCCAACAAGATCTCTCACACACAGACACACACACGCACACGCACACACGGGCGCGCACACACACGCGCGTACA
CACTGGGTCTCCAGGCAGCGGCCGTCGCCGCATCCCCGGCAGCAGCTCCAGGCAAAGTGACAGAGGACAGTGCTGCTGTGAGTTTGACGA
AGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTT
CCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAA
ATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAG
AACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCT
GCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCT
GTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATG
GAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAA
GAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGC
TCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATT
TCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCAT
GTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTC
ACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAG
TGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGG
CAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTG
GCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCT
TCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACT
ACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCA
TTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCA
AGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAA
TGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAA
GGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAAT
ATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACAT
ATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGA
GAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATG
GAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAG
TTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGAC
CTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTT
TCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTA
TAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTT
AGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAG
AGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATT
TATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGG
AAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTG
CTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATA
TTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAA
ATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGA
GTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATT
AAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGAT
TACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAA
AAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTG
AAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCC
TGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTT
GCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAA
TGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGC

>In-frame_PLCB4_ENST00000378473_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_1017nt
AGTAAGTGAGCTGCACCGCCAACAAGATCTCTCACACACAGACACACACACGCACACGCACACACGGGCGCGCACACACACGCGCGTACA
CACTGGGTCTCCAGGCAGCGGCCGTCGCCGCATCCCCGGCAGCAGCTCCAGGCAAAGTGACAGAGGACAGTGCTGCTGTGAGTTTGACGA
AGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTT
CCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAA
ATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAG
AACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCT
GCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCT
GTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATG
GAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAA
GAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCG

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4116nt
AGGACAGTGCTGCTGTGAGTTTGACGAAGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCT
TATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTC
TGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGAT
GTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGT
GTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACA
AAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATT
GAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATT
CCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGT
GACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCG
CAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGG
AAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGT
TTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCA
GGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGT
TTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCA
GACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGG
TTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGG
TGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTT
GGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAG
TTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTC
CATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCA
GTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAA
CCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACC
ATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAG
TCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTAC
TTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAA
AATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTG
GATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGA
CATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCC
TCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGA
CAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGC
TCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAG
AGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTA
TCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGA
AGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATC
TATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAA
GTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTG
CTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAA
CTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAG
TAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATG
ATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAA
TTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTG
TATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTAC
ATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTT
ACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGT
GCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTG

>In-frame_PLCB4_ENST00000278655_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_864nt
AGGACAGTGCTGCTGTGAGTTTGACGAAGTGGACATCACCTGCAGTCAGTCCAGAGCTGCCCAGTCTTGAATATAATCATGGCCAAACCT
TATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGATACGAGGAGGTGGATCGGATCATTTTC
TGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGAT
GTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGT
GTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACA
AAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATT
GAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATT
CCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGT
GACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAA

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4053nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAAT
GGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTG
GGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAA
AAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTC
TGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTT
ATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCA
ATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGAC
AATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGA
GCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTT
GACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAA
AGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAG
CTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAAT
TACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATT
CAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTG
GTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTAC
TTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCT
TGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGA
TGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTA
GCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCT
AACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTC
CAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATC
CAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGT
ATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAA
AAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGA
AATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGG
GAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCG
ACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACA
GTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTG
AACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATA
AATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTA
GTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTT
TTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACT
GGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATG
CACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATAT
TTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAG
TAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGG
TATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCA
TCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGAGAGGATAATGTG

>In-frame_PLCB4_ENST00000414679_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_801nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGAC

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4053nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAAT
GGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTG
GGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAA
AAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTC
TGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTT
ATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCA
ATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGAC
AATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGA
GCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTT
GACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAA
AGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAG
CTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAAT
TACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATT
CAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTG
GTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTAC
TTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCT
TGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGA
TGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTA
GCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCT
AACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTC
CAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATC
CAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGT
ATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAA
AAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGA
AATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGG
GAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCG
ACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACA
GTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTG
AACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATA
AATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTA
GTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTT
TTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACT
GGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATG
CACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATAT
TTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAG
TAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGG
TATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCA
TCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGAGAGGATAATGTG

>In-frame_PLCB4_ENST00000378501_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_801nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGAC

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000217246_chr20_15843390_+_4053nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAAT
GGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTG
GGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAA
AAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTC
TGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTT
ATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCA
ATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGAC
AATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGA
GCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTT
GACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAA
AGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAG
CTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAAT
TACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATT
CAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTG
GTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTAC
TTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCT
TGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGA
TGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTA
GCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCT
AACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTC
CAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATC
CAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGT
ATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAA
AAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGA
AATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGG
GAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCG
ACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACA
GTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTG
AACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATA
AATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTA
GTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTT
TTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACT
GGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATG
CACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATAT
TTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAG
TAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGG
TATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCA
TCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGAGAGGATAATGTG

>In-frame_PLCB4_ENST00000378493_chr20_9288545_+_MACROD2_ENST00000310348_chr20_15843390_+_801nt
GTCTTGAATATAATCATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGAGCAGTTTTTGACAGA
TACGAGGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTA
GACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATG
GAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAA
GATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAAT
GATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCC
GTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGG
ATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGAC


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FusionGenePPI for PLCB4_MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLCB4REL, NLGN3MACROD2TERF1, TERF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLCB4_MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLCB4_MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLCB4C0025202melanoma1CTD_human
HgenePLCB4C0220633Uveal melanoma1CTD_human
HgenePLCB4C3553404AURICULOCONDYLAR SYNDROME 21UNIPROT
TgeneMACROD2C0004352Autistic Disorder1CTD_human
TgeneMACROD2C0023903Liver neoplasms1CTD_human
TgeneMACROD2C0236969Substance-Related Disorders1CTD_human