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Fusion gene ID: 27495 |
FusionGeneSummary for PLCB3_PGA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCB3_PGA5 | Fusion gene ID: 27495 | Hgene | Tgene | Gene symbol | PLCB3 | PGA5 | Gene ID | 5331 | 5222 |
| Gene name | phospholipase C beta 3 | pepsinogen 5, group I (pepsinogen A) | |
| Synonyms | - | Pg5 | |
| Cytomap | 11q13.1 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3PLC beta 3phosphoinositide phospholipase C-beta-3phospholipase C, beta 3 (phosphatidylinositol-specific) | pepsin A-5pepsin Apepsinogen A5pepsinogen-5 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q01970 | P0DJD9 | |
| Ensembl transtripts involved in fusion gene | ENST00000279230, ENST00000540288, ENST00000325234, | ENST00000312403, ENST00000451616, ENST00000541528, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PLCB3 [Title/Abstract] AND PGA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCB3 | GO:0003073 | regulation of systemic arterial blood pressure | 18468998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-LL-A6FQ-01A | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000279230 | ENST00000312403 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000279230 | ENST00000451616 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000279230 | ENST00000541528 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| In-frame | ENST00000540288 | ENST00000312403 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000540288 | ENST00000451616 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000540288 | ENST00000541528 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| In-frame | ENST00000325234 | ENST00000312403 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000325234 | ENST00000451616 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
| 5CDS-intron | ENST00000325234 | ENST00000541528 | PLCB3 | chr11 | 64023088 | + | PGA5 | chr11 | 61013418 | + |
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FusionProtFeatures for PLCB3_PGA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLCB3 | PGA5 |
| The production of the second messenger moleculesdiacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ismediated by activated phosphatidylinositol-specific phospholipaseC enzymes. | Shows particularly broad specificity; although bondsinvolving phenylalanine and leucine are preferred, many others arealso cleaved to some extent. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000279230 | + | 7 | 31 | 318_468 | 199 | 1235 | Domain | PI-PLC X-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000279230 | + | 7 | 31 | 590_706 | 199 | 1235 | Domain | PI-PLC Y-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000279230 | + | 7 | 31 | 713_810 | 199 | 1235 | Domain | C2 |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000325234 | + | 5 | 29 | 318_468 | 132 | 1168 | Domain | PI-PLC X-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000325234 | + | 5 | 29 | 590_706 | 132 | 1168 | Domain | PI-PLC Y-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000325234 | + | 5 | 29 | 713_810 | 132 | 1168 | Domain | C2 |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000540288 | + | 7 | 32 | 318_468 | 199 | 1383 | Domain | PI-PLC X-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000540288 | + | 7 | 32 | 590_706 | 199 | 1383 | Domain | PI-PLC Y-box |
| Hgene | >PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000540288 | + | 7 | 32 | 713_810 | 199 | 1383 | Domain | C2 |
| Tgene | PGA5 | chr11:64023088 | chr11:61013418 | ENST00000312403 | + | 3 | 9 | 76_385 | 152 | 389 | Domain | Peptidase A1 |
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FusionGeneSequence for PLCB3_PGA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLCB3_ENST00000279230_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_436aa MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVL GFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS ADKKRVETALESCGLKFNRVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKS GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSA >In-frame_PLCB3_ENST00000540288_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_436aa MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVL GFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS ADKKRVETALESCGLKFNRVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKS GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSA >In-frame_PLCB3_ENST00000325234_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_369aa MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAY TKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFD NIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPI ANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGELWILGDVFIRQYFTVFDRANN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLCB3_ENST00000279230_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1308nt ATGGCGGGCGCCCAGCCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAGTAAGTTCATCAAA TGGGACGAGGAGACCTCCAGTCGGAACCTGGTGACCCTGCGTGTGGACCCCAATGGCTTCTTCTTGTACTGGACGGGCCCCAACATGGAG GTGGACACACTGGACATCAGTTCCATCAGGGACACACGGACAGGCCGGTACGCCCGCCTGCCCAAGGACCCCAAGATCCGGGAAGTTCTG GGCTTTGGGGGTCCCGATGCCCGGCTGGAGGAGAAGCTGATGACGGTGGTGTCTGGGCCAGACCCAGTGAACACAGTGTTCTTGAACTTC ATGGCCGTGCAGGATGACACAGCCAAGGTCTGGTCTGAGGAGCTATTCAAGCTGGCTATGAACATCCTGGCTCAGAACGCCTCCCGGAAC ACCTTCCTGCGCAAAGCATACACGAAGCTGAAGCTGCAGGTGAACCAGGATGGTCGGATCCCCGTCAAGAACATCCTGAAGATGTTCTCA GCAGACAAGAAGCGGGTGGAGACTGCGCTGGAATCCTGTGGCCTCAAATTCAACCGGGTTGGAGGCATCTCTGACACCAATCAGATCTTC GGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCC GGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACAAGAGT GGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAG ATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTGCTG ACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCC ATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGGAGC TGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACC >In-frame_PLCB3_ENST00000540288_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1308nt ATGGCGGGCGCCCAGCCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAGTAAGTTCATCAAA TGGGACGAGGAGACCTCCAGTCGGAACCTGGTGACCCTGCGTGTGGACCCCAATGGCTTCTTCTTGTACTGGACGGGCCCCAACATGGAG GTGGACACACTGGACATCAGTTCCATCAGGGACACACGGACAGGCCGGTACGCCCGCCTGCCCAAGGACCCCAAGATCCGGGAAGTTCTG GGCTTTGGGGGTCCCGATGCCCGGCTGGAGGAGAAGCTGATGACGGTGGTGTCTGGGCCAGACCCAGTGAACACAGTGTTCTTGAACTTC ATGGCCGTGCAGGATGACACAGCCAAGGTCTGGTCTGAGGAGCTATTCAAGCTGGCTATGAACATCCTGGCTCAGAACGCCTCCCGGAAC ACCTTCCTGCGCAAAGCATACACGAAGCTGAAGCTGCAGGTGAACCAGGATGGTCGGATCCCCGTCAAGAACATCCTGAAGATGTTCTCA GCAGACAAGAAGCGGGTGGAGACTGCGCTGGAATCCTGTGGCCTCAAATTCAACCGGGTTGGAGGCATCTCTGACACCAATCAGATCTTC GGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCC GGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACAAGAGT GGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAG ATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTGCTG ACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCC ATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGGAGC TGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACC >In-frame_PLCB3_ENST00000325234_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1107nt ATGGCGGGCGCCCAGCCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAGTAAGTTCATCAAA TGGGACGAGGAGAAGCTGATGACGGTGGTGTCTGGGCCAGACCCAGTGAACACAGTGTTCTTGAACTTCATGGCCGTGCAGGATGACACA GCCAAGGTCTGGTCTGAGGAGCTATTCAAGCTGGCTATGAACATCCTGGCTCAGAACGCCTCCCGGAACACCTTCCTGCGCAAAGCATAC ACGAAGCTGAAGCTGCAGGTGAACCAGGATGGTCGGATCCCCGTCAAGAACATCCTGAAGATGTTCTCAGCAGACAAGAAGCGGGTGGAG ACTGCGCTGGAATCCTGTGGCCTCAAATTCAACCGGGTTGGAGGCATCTCTGACACCAATCAGATCTTCGGCCTGAGCGAGACGGAACCT GGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGAC AACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACAAGAGTGGCAGCGTGGTGATCTTTGGT GGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAGATCACCGTGGACAGCATCACC ATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTGCTGACCGGCCCAACCAGCCCCATT GCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCCATCAGCAGCCTGCCCGACATC GTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGC ATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLCB3_ENST00000279230_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1602nt CCGGGACAGACTGGCGGGCGGGCGGGCACTGACGCCGCGGGGCCGGAGCGGGCCGCGCGGTGGGAGCAGCGGCGCCGTCGGTCCCCGTCA GGGCTCCGTGGGTCCCCGACCCGCCCCTGGCCGGGCCATGGCGGGCGCCCAGCCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGT GGTGGAGACCCTGCGGCGCGGGAGTAAGTTCATCAAATGGGACGAGGAGACCTCCAGTCGGAACCTGGTGACCCTGCGTGTGGACCCCAA TGGCTTCTTCTTGTACTGGACGGGCCCCAACATGGAGGTGGACACACTGGACATCAGTTCCATCAGGGACACACGGACAGGCCGGTACGC CCGCCTGCCCAAGGACCCCAAGATCCGGGAAGTTCTGGGCTTTGGGGGTCCCGATGCCCGGCTGGAGGAGAAGCTGATGACGGTGGTGTC TGGGCCAGACCCAGTGAACACAGTGTTCTTGAACTTCATGGCCGTGCAGGATGACACAGCCAAGGTCTGGTCTGAGGAGCTATTCAAGCT GGCTATGAACATCCTGGCTCAGAACGCCTCCCGGAACACCTTCCTGCGCAAAGCATACACGAAGCTGAAGCTGCAGGTGAACCAGGATGG TCGGATCCCCGTCAAGAACATCCTGAAGATGTTCTCAGCAGACAAGAAGCGGGTGGAGACTGCGCTGGAATCCTGTGGCCTCAAATTCAA CCGGGTTGGAGGCATCTCTGACACCAATCAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGG CATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGA CCTCTTCTCTGTCTACCTCAGCGCCGATGACAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCT GAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGG CTGCCAGGCCATTGTTGACACCGGCACCTCTCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGA GAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGT GCCACCCAGTGCCTACATCCTGCAGAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTG GATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCTGTGGCTTAAGCCTA AGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCCTCCGTCCTATGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGG >In-frame_PLCB3_ENST00000540288_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1578nt GGCACTGACGCCGCGGGGCCGGAGCGGGCCGCGCGGTGGGAGCAGCGGCGCCGTCGGTCCCCGTCAGGGCTCCGTGGGTCCCCGACCCGC CCCTGGCCGGGCCATGGCGGGCGCCCAGCCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAG TAAGTTCATCAAATGGGACGAGGAGACCTCCAGTCGGAACCTGGTGACCCTGCGTGTGGACCCCAATGGCTTCTTCTTGTACTGGACGGG CCCCAACATGGAGGTGGACACACTGGACATCAGTTCCATCAGGGACACACGGACAGGCCGGTACGCCCGCCTGCCCAAGGACCCCAAGAT CCGGGAAGTTCTGGGCTTTGGGGGTCCCGATGCCCGGCTGGAGGAGAAGCTGATGACGGTGGTGTCTGGGCCAGACCCAGTGAACACAGT GTTCTTGAACTTCATGGCCGTGCAGGATGACACAGCCAAGGTCTGGTCTGAGGAGCTATTCAAGCTGGCTATGAACATCCTGGCTCAGAA CGCCTCCCGGAACACCTTCCTGCGCAAAGCATACACGAAGCTGAAGCTGCAGGTGAACCAGGATGGTCGGATCCCCGTCAAGAACATCCT GAAGATGTTCTCAGCAGACAAGAAGCGGGTGGAGACTGCGCTGGAATCCTGTGGCCTCAAATTCAACCGGGTTGGAGGCATCTCTGACAC CAATCAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAG CATTTCCTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGC CGATGACAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGA GGGTTACTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGG CACCTCTCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGT CAGCTGCTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCA GAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCG CCAGTACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCTGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGA AGATCTGGCCTCCGTCCTATGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGAAGGTCTTGGCCCTGTTC >In-frame_PLCB3_ENST00000325234_chr11_64023088_+_PGA5_ENST00000312403_chr11_61013418_+_1349nt CCGCGCGGTGGGAGCAGCGGCGCCGTCGGTCCCCGTCAGGGCTCCGTGGGTCCCCGACCCGCCCCTGGCCGGGCCATGGCGGGCGCCCAG CCCGGCGTCCACGCGCTGCAGTTGGAGCCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAGTAAGTTCATCAAATGGGACGAGGAGAAG CTGATGACGGTGGTGTCTGGGCCAGACCCAGTGAACACAGTGTTCTTGAACTTCATGGCCGTGCAGGATGACACAGCCAAGGTCTGGTCT GAGGAGCTATTCAAGCTGGCTATGAACATCCTGGCTCAGAACGCCTCCCGGAACACCTTCCTGCGCAAAGCATACACGAAGCTGAAGCTG CAGGTGAACCAGGATGGTCGGATCCCCGTCAAGAACATCCTGAAGATGTTCTCAGCAGACAAGAAGCGGGTGGAGACTGCGCTGGAATCC TGTGGCCTCAAATTCAACCGGGTTGGAGGCATCTCTGACACCAATCAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTAT TATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAG GGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCT TACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGACC ATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGC GACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAAT GGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACC GAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCC CCTGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCCTCCGTCCTATGCCCACTTTAGATGTATCTAATTCTCCTG |
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FusionGenePPI for PLCB3_PGA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLCB3 | TRPM7, SLC9A3R2, KRIT1, NAA16, SNTA1, XRCC5, MOV10, NXF1, SMYD3, SORT1, SYNCRIP, NEDD1, LPAR2, CDH1 | PGA5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000279230 | + | 7 | 31 | 1231_1234 | 199 | 1235 | SHANK2 |
| Hgene | PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000325234 | + | 5 | 29 | 1231_1234 | 132 | 1168 | SHANK2 |
| Hgene | PLCB3 | chr11:64023088 | chr11:61013418 | ENST00000540288 | + | 7 | 32 | 1231_1234 | 199 | 1383 | SHANK2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLCB3_PGA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLCB3_PGA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PGA5 | C0014868 | Esophagitis | 1 | CTD_human |
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