FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27478

FusionGeneSummary for PLCB1_GTF2A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCB1_GTF2A1
Fusion gene ID: 27478
HgeneTgene
Gene symbol

PLCB1

GTF2A1

Gene ID

23236

2957

Gene namephospholipase C beta 1general transcription factor IIA subunit 1
SynonymsEIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1BTF2A1|TFIIA|TFIIA-42|TFIIAL
Cytomap

20p12.3

14q31.1

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphospholipase C, beta 1 (phosphoinositide-specifictranscription initiation factor IIA subunit 1TFIIA alpha, p55TFIIA alpha/beta subunitsgeneral transcription factor IIA 1general transcription factor IIA, 1, 19/37kDaglucose regulated protein, 58kD pseudogenetranscription initiation factor TFIIA 42 k
Modification date2018051920180523
UniProtAcc

Q9NQ66

P52655

Ensembl transtripts involved in fusion geneENST00000378641, ENST00000338037, 
ENST00000378637, ENST00000494924, 
ENST00000553612, ENST00000434192, 
Fusion gene scores* DoF score13 X 9 X 9=10532 X 2 X 2=8
# samples 112
** MAII scorelog2(11/1053*10)=-3.25893000750106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PLCB1 [Title/Abstract] AND GTF2A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLCB1

GO:0035722

interleukin-12-mediated signaling pathway

11743656

HgenePLCB1

GO:0035723

interleukin-15-mediated signaling pathway

11743656

HgenePLCB1

GO:0046330

positive regulation of JNK cascade

9500449

HgenePLCB1

GO:0070498

interleukin-1-mediated signaling pathway

8872139

TgeneGTF2A1

GO:0006366

transcription by RNA polymerase II

7724559|7958900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE835662PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000378641ENST00000553612PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-intronENST00000378641ENST00000434192PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-5UTRENST00000338037ENST00000553612PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-intronENST00000338037ENST00000434192PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-5UTRENST00000378637ENST00000553612PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-intronENST00000378637ENST00000434192PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-5UTRENST00000494924ENST00000553612PLCB1chr20

8188789

-GTF2A1chr14

81686939

+
intron-intronENST00000494924ENST00000434192PLCB1chr20

8188789

-GTF2A1chr14

81686939

+

Top

FusionProtFeatures for PLCB1_GTF2A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLCB1

Q9NQ66

GTF2A1

P52655

TFIIA is a component of the transcription machinery ofRNA polymerase II and plays an important role in transcriptionalactivation. TFIIA in a complex with TBP mediates transcriptionalactivity. {ECO:0000269|PubMed:11030333,ECO:0000269|PubMed:16537915}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PLCB1_GTF2A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PLCB1_GTF2A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PLCB1_GTF2A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PLCB1_GTF2A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLCB1C0005586Bipolar Disorder1PSYGENET
HgenePLCB1C0009375Colonic Neoplasms1CTD_human
HgenePLCB1C0030193Pain1CTD_human
HgenePLCB1C0036341Schizophrenia1CTD_human
HgenePLCB1C0041696Unipolar Depression1PSYGENET
HgenePLCB1C1269683Major Depressive Disorder1PSYGENET
HgenePLCB1C3463824MYELODYSPLASTIC SYNDROME1CTD_human