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Fusion gene ID: 27473 |
FusionGeneSummary for PLBD2_CIDEC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLBD2_CIDEC | Fusion gene ID: 27473 | Hgene | Tgene | Gene symbol | PLBD2 | CIDEC | Gene ID | 196463 | 63924 |
| Gene name | phospholipase B domain containing 2 | cell death inducing DFFA like effector c | |
| Synonyms | P76 | CIDE-3|CIDE3|FPLD5|FSP27 | |
| Cytomap | 12q24.13 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative phospholipase B-like 276 kDa proteinLAMA-like protein 2PLB homolog 2lamina ancestor homolog 2mannose-6-phosphate protein associated protein p76phospholipase B domain-containing protein 2phospholipase B-like 2 32 kDa formphospholipase B-li | cell death activator CIDE-3fat specific protein 27 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NHP8 | Q96AQ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000545182, ENST00000280800, ENST00000547163, | ENST00000455015, ENST00000336832, ENST00000423850, ENST00000383817, ENST00000430427, ENST00000443115, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 6 X 3=126 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLBD2 [Title/Abstract] AND CIDEC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CIDEC | GO:0006915 | apoptotic process | 12429024 |
| Tgene | CIDEC | GO:0097194 | execution phase of apoptosis | 12429024 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5L6-01A | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000545182 | ENST00000455015 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000545182 | ENST00000336832 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000545182 | ENST00000423850 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000545182 | ENST00000383817 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000545182 | ENST00000430427 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-intron | ENST00000545182 | ENST00000443115 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000280800 | ENST00000455015 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000280800 | ENST00000336832 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000280800 | ENST00000423850 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000280800 | ENST00000383817 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-5UTR | ENST00000280800 | ENST00000430427 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| 5CDS-intron | ENST00000280800 | ENST00000443115 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-5UTR | ENST00000547163 | ENST00000455015 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-5UTR | ENST00000547163 | ENST00000336832 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-5UTR | ENST00000547163 | ENST00000423850 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-5UTR | ENST00000547163 | ENST00000383817 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-5UTR | ENST00000547163 | ENST00000430427 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
| intron-intron | ENST00000547163 | ENST00000443115 | PLBD2 | chr12 | 113796695 | + | CIDEC | chr3 | 9920195 | - |
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FusionProtFeatures for PLBD2_CIDEC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLBD2 | CIDEC |
| Putative phospholipase. {ECO:0000250}. | Binds to lipid droplets and regulates their enlargement,thereby restricting lipolysis and favoring storage. At focalcontact sites between lipid droplets, promotes directional netneutral lipid transfer from the smaller to larger lipid droplets.The transfer direction may be driven by the internal pressuredifference between the contacting lipid droplet pair. Its role inneutral lipid transfer and lipid droplet enlargement is activatedby the interaction with PLIN1. May act as a CEBPB coactivator inthe white adipose tissue to control the expression of a subset ofCEBPB downstream target genes, including SOCS1, SOCS3, TGFB1,TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, inducesapoptosis or increases cell susceptibility to apoptosis induced byserum deprivation or TGFB treatment. As mature adipocytes, thatexpress high CIDEC levels, are quite resistant to apoptoticstimuli, the physiological significance of its role in apoptosisis unclear. May play a role in the modulation of the response toosmotic stress by preventing NFAT5 to translocate into the nucleusand activate its target genes expression.{ECO:0000269|PubMed:12429024, ECO:0000269|PubMed:18334488,ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:20049731,ECO:0000269|PubMed:23399566}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLBD2_CIDEC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLBD2_CIDEC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLBD2 | WDHD1, RBM12, FBXO6, MRPL9, TBCB, MYH11, TFG, ZWINT, STRAP, CHORDC1, KIAA0368, TRIM25 | CIDEC | VCP, CIDEA, CIDEC, EGR1, PRSS2, TOP1, AMFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLBD2_CIDEC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLBD2_CIDEC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CIDEC | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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