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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27467

FusionGeneSummary for PLAUR_ZNF576

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR_ZNF576
Fusion gene ID: 27467
HgeneTgene
Gene symbol

PLAUR

ZNF576

Gene ID

5329

100170229

Gene nameplasminogen activator, urokinase receptorserine/arginine repetitive matrix 5
SynonymsCD87|U-PAR|UPAR|URKRZNF576
Cytomap

19q13.31

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptorserine/arginine repetitive matrix protein 5zinc finger protein 576
Modification date2018052320180329
UniProtAcc

Q03405

Q9H609

Ensembl transtripts involved in fusion geneENST00000339082, ENST00000601723, 
ENST00000340093, ENST00000221264, 
ENST00000391965, ENST00000525771, 
ENST00000533118, ENST00000528387, 
ENST00000529930, ENST00000336564, 
Fusion gene scores* DoF score6 X 4 X 5=1202 X 2 X 2=8
# samples 62
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PLAUR [Title/Abstract] AND ZNF576 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-NJ-A4YQ-01APLAURchr19

44169468

-ZNF576chr19

44102983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339082ENST00000391965PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000339082ENST00000525771PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000339082ENST00000533118PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000339082ENST00000528387PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000339082ENST00000529930PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000339082ENST00000336564PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000601723ENST00000391965PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000601723ENST00000525771PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000601723ENST00000533118PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000601723ENST00000528387PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000601723ENST00000529930PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000601723ENST00000336564PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000340093ENST00000391965PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000340093ENST00000525771PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000340093ENST00000533118PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000340093ENST00000528387PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000340093ENST00000529930PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000340093ENST00000336564PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000221264ENST00000391965PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000221264ENST00000525771PLAURchr19

44169468

-ZNF576chr19

44102983

+
In-frameENST00000221264ENST00000533118PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000221264ENST00000528387PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000221264ENST00000529930PLAURchr19

44169468

-ZNF576chr19

44102983

+
Frame-shitENST00000221264ENST00000336564PLAURchr19

44169468

-ZNF576chr19

44102983

+

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FusionProtFeatures for PLAUR_ZNF576


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLAUR

Q03405

ZNF576

Q9H609

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF576chr19:44169468chr19:44102983ENST00000336564+13112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000336564+13143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000336564+1334_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000336564+1371_9328171Zinc fingerC2H2-type 2
TgeneZNF576chr19:44169468chr19:44102983ENST00000391965+13112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000391965+13143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000391965+1334_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000391965+1371_9328171Zinc fingerC2H2-type 2
TgeneZNF576chr19:44169468chr19:44102983ENST00000525771+02112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000525771+02143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000525771+0234_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000525771+0271_9328171Zinc fingerC2H2-type 2
TgeneZNF576chr19:44169468chr19:44102983ENST00000528387+13112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000528387+13143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000528387+1334_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000528387+1371_9328171Zinc fingerC2H2-type 2
TgeneZNF576chr19:44169468chr19:44102983ENST00000529930+13112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000529930+13143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000529930+1334_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000529930+1371_9328171Zinc fingerC2H2-type 2
TgeneZNF576chr19:44169468chr19:44102983ENST00000533118+13112_13428171Zinc fingerC2H2-type 3
TgeneZNF576chr19:44169468chr19:44102983ENST00000533118+13143_16528171Zinc fingerC2H2-type 4
TgeneZNF576chr19:44169468chr19:44102983ENST00000533118+1334_5728171Zinc fingerC2H2-type 1
TgeneZNF576chr19:44169468chr19:44102983ENST00000533118+1371_9328171Zinc fingerC2H2-type 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLAURchr19:44169468chr19:44102983ENST00000221264-36115_213103291DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44169468chr19:44102983ENST00000221264-36214_305103291DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44169468chr19:44102983ENST00000221264-3623_114103291DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44169468chr19:44102983ENST00000339082-37115_213103282DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44169468chr19:44102983ENST00000339082-37214_305103282DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44169468chr19:44102983ENST00000339082-3723_114103282DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44169468chr19:44102983ENST00000340093-37115_213103336DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44169468chr19:44102983ENST00000340093-37214_305103336DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44169468chr19:44102983ENST00000340093-3723_114103336DomainNote=UPAR/Ly6 1


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FusionGeneSequence for PLAUR_ZNF576


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLAUR_ZNF576


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLAURITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16ZNF576RARG, SUOX, MAPKAPK5, AES, KRT15, AP4B1, SH3GLB1, POGZ, ZNF618, AJUBA, ZBTB40, ZBED1, ZBTB10, LIMD1, RBBP6, PDLIM7, ZBTB33, ZNF446, UPF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLAUR_ZNF576


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLAURQ03405DB00009AlteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00029AnistreplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00031TenecteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00015ReteplaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational
HgenePLAURQ03405DB00013UrokinaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for PLAUR_ZNF576


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLAURC0004352Autistic Disorder2CTD_human
HgenePLAURC0021368Inflammation1CTD_human
HgenePLAURC0027626Neoplasm Invasiveness1CTD_human
HgenePLAURC0027627Neoplasm Metastasis1CTD_human
HgenePLAURC0033578Prostatic Neoplasms1CTD_human
HgenePLAURC3495559Juvenile arthritis1CTD_human