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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27465

FusionGeneSummary for PLAUR_WDR45

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR_WDR45
Fusion gene ID: 27465
HgeneTgene
Gene symbol

PLAUR

WDR45

Gene ID

5329

11152

Gene nameplasminogen activator, urokinase receptorWD repeat domain 45
SynonymsCD87|U-PAR|UPAR|URKRJM5|NBIA4|NBIA5|WDRX1|WIPI-4|WIPI4
Cytomap

19q13.31

Xp11.23

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptorWD repeat domain phosphoinositide-interacting protein 4WD repeat domain, X-linked 1WD repeat-containing protein 45WD45 repeat protein interacting with phosphoinositides 4neurodegeneration with brain iron accumulation 4neurodegeneration with brain iro
Modification date2018052320180523
UniProtAcc

Q03405

Q9Y484

Ensembl transtripts involved in fusion geneENST00000339082, ENST00000601723, 
ENST00000340093, ENST00000221264, 
ENST00000553851, ENST00000376372, 
ENST00000322995, ENST00000356463, 
ENST00000485908, ENST00000473974, 
ENST00000376368, ENST00000396681, 
ENST00000465431, 
Fusion gene scores* DoF score6 X 4 X 5=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PLAUR [Title/Abstract] AND WDR45 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A3TO-01APLAURchr19

44169468

-WDR45chrX

48935771

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339082ENST00000553851PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000376372PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000322995PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000356463PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000485908PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000473974PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000376368PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000396681PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000339082ENST00000465431PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000553851PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000376372PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000322995PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000356463PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000485908PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000473974PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000376368PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000396681PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000601723ENST00000465431PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000553851PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000376372PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000322995PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000356463PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000485908PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000473974PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000376368PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000396681PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000340093ENST00000465431PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000553851PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000376372PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000322995PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000356463PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000485908PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000473974PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000376368PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000396681PLAURchr19

44169468

-WDR45chrX

48935771

-
5CDS-5UTRENST00000221264ENST00000465431PLAURchr19

44169468

-WDR45chrX

48935771

-

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FusionProtFeatures for PLAUR_WDR45


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLAUR

Q03405

WDR45

Q9Y484

Plays an important role in the autophagy pathway, whichis the major intracellular degradation system by which cytoplasmicmaterials are packaged into autophagosomes and delivered tolysosomes for degradation. {ECO:0000269|PubMed:23435086}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLAUR_WDR45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLAUR_WDR45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLAURITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16WDR45ATG2A, ATG2B, CLNS1A, APP, SLC25A11, TALDO1, LHX6, CEP89, POC1A, XPO1, DUSP26, HDAC11, SPAST, DRD2, SALL2, XAGE1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLAUR_WDR45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLAURQ03405DB00009AlteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00029AnistreplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00031TenecteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00015ReteplaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational
HgenePLAURQ03405DB00013UrokinaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for PLAUR_WDR45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLAURC0004352Autistic Disorder2CTD_human
HgenePLAURC0021368Inflammation1CTD_human
HgenePLAURC0027626Neoplasm Invasiveness1CTD_human
HgenePLAURC0027627Neoplasm Metastasis1CTD_human
HgenePLAURC0033578Prostatic Neoplasms1CTD_human
HgenePLAURC3495559Juvenile arthritis1CTD_human
TgeneWDR45C2931845Neurodegeneration with brain iron accumulation (NBIA)1CTD_human