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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27463

FusionGeneSummary for PLAUR_BABAM1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR_BABAM1
Fusion gene ID: 27463
HgeneTgene
Gene symbol

PLAUR

BABAM1

Gene ID

5329

29086

Gene nameplasminogen activator, urokinase receptorBRISC and BRCA1 A complex member 1
SynonymsCD87|U-PAR|UPAR|URKRC19orf62|HSPC142|MERIT40|NBA1
Cytomap

19q13.31

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptorBRISC and BRCA1-A complex member 1BRCA1-A complex subunit MERIT40mediator of RAP80 interactions and targeting subunit of 40 kDamediator of Rap80 interactions and targeting 40 kDanew component of the BRCA1-A complexnew component of the BRCAA1 A comple
Modification date2018052320180522
UniProtAcc

Q03405

Q9NWV8

Ensembl transtripts involved in fusion geneENST00000339082, ENST00000601723, 
ENST00000340093, ENST00000221264, 
ENST00000598188, ENST00000359435, 
ENST00000447614, ENST00000601043, 
ENST00000448635, ENST00000595632, 
Fusion gene scores* DoF score6 X 4 X 5=1203 X 3 X 3=27
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLAUR [Title/Abstract] AND BABAM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1558-01APLAURchr19

44174218

-BABAM1chr19

17378211

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339082ENST00000598188PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000339082ENST00000359435PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000339082ENST00000447614PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000339082ENST00000601043PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000339082ENST00000448635PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000339082ENST00000595632PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000601723ENST00000598188PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000601723ENST00000359435PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000601723ENST00000447614PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000601723ENST00000601043PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000601723ENST00000448635PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000601723ENST00000595632PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000340093ENST00000598188PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000340093ENST00000359435PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000340093ENST00000447614PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000340093ENST00000601043PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000340093ENST00000448635PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000340093ENST00000595632PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000221264ENST00000598188PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-5UTRENST00000221264ENST00000359435PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000221264ENST00000447614PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000221264ENST00000601043PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000221264ENST00000448635PLAURchr19

44174218

-BABAM1chr19

17378211

+
5CDS-intronENST00000221264ENST00000595632PLAURchr19

44174218

-BABAM1chr19

17378211

+

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FusionProtFeatures for PLAUR_BABAM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLAUR

Q03405

BABAM1

Q9NWV8

Component of the BRCA1-A complex, a complex thatspecifically recognizes 'Lys-63'-linked ubiquitinated histones H2Aand H2AX at DNA lesions sites, leading to target the BRCA1-BARD1heterodimer to sites of DNA damage at double-strand breaks (DSBs).The BRCA1-A complex also possesses deubiquitinase activity thatspecifically removes 'Lys-63'-linked ubiquitin on histones H2A andH2AX. In the BRCA1-A complex, it is required for the complexintegrity and its localization at DSBs. Component of the BRISCcomplex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985,PubMed:26195665). In these 2 complexes, it is probably required tomaintain the stability of BABAM2 and help the 'Lys-63'-linkeddeubiquitinase activity mediated by BRCC3/BRCC36 component. TheBRISC complex is required for normal mitotic spindle assembly andmicrotubule attachment to kinetochores via its role indeubiquitinating NUMA1 (PubMed:26195665). Plays a role ininterferon signaling via its role in the deubiquitination of theinterferon receptor IFNAR1; deubiquitination increases IFNAR1activity by enhancing its stability and cell surface expression(PubMed:24075985). Down-regulates the response to bacteriallipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985). {ECO:0000269|PubMed:19261746,ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLAUR_BABAM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLAUR_BABAM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLAURITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16BABAM1BRE, ARF4, GNAL, NDUFA5, NSF, PDHA1, PLK1, PRKAG1, PSMA4, RANGAP1, SHMT2, SLC25A11, TNKS, GMPS, VPS4B, MELK, SLC25A13, DDX39A, MICU1, CLPX, PARK7, DIS3, FAM175B, PRDX5, VPS4A, BRCC3, USP7, SPATA2, UIMC1, UBXN1, PBDC1, UGGT2, LRRC47, AASDHPPT, PYCRL, SLIRP, FAM175A, GPT2, ATAD1, MRPL53, SFXN4, FAM210A, UBC, BRCA1, TERF2IP, GRB2, PCNA, MDC1, PAXIP1, AKAP2, CSTF2, TFG, TRIM27, MOV10, NXF1, TNKS2, DEF6, PRKAR2B, SNW1, TNS1, FAM189B, TENC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLAUR_BABAM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLAURQ03405DB00009AlteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00029AnistreplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00031TenecteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00015ReteplaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational
HgenePLAURQ03405DB00013UrokinaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for PLAUR_BABAM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLAURC0004352Autistic Disorder2CTD_human
HgenePLAURC0021368Inflammation1CTD_human
HgenePLAURC0027626Neoplasm Invasiveness1CTD_human
HgenePLAURC0027627Neoplasm Metastasis1CTD_human
HgenePLAURC0033578Prostatic Neoplasms1CTD_human
HgenePLAURC3495559Juvenile arthritis1CTD_human
TgeneBABAM1C0919267ovarian neoplasm1CTD_human