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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27462

FusionGeneSummary for PLAUR_AAMDC

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR_AAMDC
Fusion gene ID: 27462
HgeneTgene
Gene symbol

PLAUR

AAMDC

Gene ID

5329

28971

Gene nameplasminogen activator, urokinase receptoradipogenesis associated Mth938 domain containing
SynonymsCD87|U-PAR|UPAR|URKRC11orf67|CK067|PTD015
Cytomap

19q13.31

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptormth938 domain-containing proteinUPF0366 protein C11orf67adipogenesis associated Mth938 domain-containing protein
Modification date2018052320180524
UniProtAcc

Q03405

Q9H7C9

Ensembl transtripts involved in fusion geneENST00000339082, ENST00000601723, 
ENST00000340093, ENST00000221264, 
ENST00000532481, ENST00000527134, 
ENST00000304716, ENST00000526415, 
ENST00000531855, ENST00000393427, 
ENST00000525409, ENST00000533193, 
ENST00000525034, 
Fusion gene scores* DoF score6 X 4 X 5=1208 X 5 X 5=200
# samples 69
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLAUR [Title/Abstract] AND AAMDC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SQ-01APLAURchr19

44174218

-AAMDCchr11

77629107

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339082ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000601723ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000340093ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000221264ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+

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FusionProtFeatures for PLAUR_AAMDC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLAUR

Q03405

AAMDC

Q9H7C9

May play a role in preadipocyte differentiation andadipogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAAMDCchr19:44174218chr11:77629107ENST00000393427+046_122-39123RegionMTH138-like domain
TgeneAAMDCchr19:44174218chr11:77629107ENST00000526415+056_122-58123RegionMTH138-like domain

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-16115_21318291DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-16214_30518291DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-1623_11418291DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-17115_21318282DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-17214_30518282DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-1723_11418282DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-17115_21318336DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-17214_30518336DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-1723_11418336DomainNote=UPAR/Ly6 1
TgeneAAMDCchr19:44174218chr11:77629107ENST00000532481+246_1227689RegionMTH138-like domain


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FusionGeneSequence for PLAUR_AAMDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLAUR_ENST00000339082_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_31aa

>In-frame_PLAUR_ENST00000601723_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_31aa

>In-frame_PLAUR_ENST00000340093_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_31aa

>In-frame_PLAUR_ENST00000221264_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_31aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLAUR_ENST00000339082_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_94nt
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTG

>In-frame_PLAUR_ENST00000601723_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_94nt
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTG

>In-frame_PLAUR_ENST00000340093_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_94nt
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTG

>In-frame_PLAUR_ENST00000221264_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_94nt
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLAUR_ENST00000339082_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_473nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAGAAAG
AATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGAGTTT
GAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGTGGTC
CCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGAGACC

>In-frame_PLAUR_ENST00000601723_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_460nt
AGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGA
TGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAGAAAGAATGAGCCTAGGC
CGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGAGTTTGAGACCAGCCTGG
CCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGTGGTCCCAGCTACTTGGG
AGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGAGACCCTGTCTCAAAAAA

>In-frame_PLAUR_ENST00000340093_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_657nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAG
AAAGAATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGA
GTTTGAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGT
GGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGA

>In-frame_PLAUR_ENST00000221264_chr19_44174218_-_AAMDC_ENST00000532481_chr11_77629107_+_854nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCA
GAAGATGAAGACAGAAGAAAGAATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGG
ATCACTTGAGCTCAGGAGTTTGAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTG
TGGTGGCATATGCCTGTGGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAG


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FusionGenePPI for PLAUR_AAMDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLAURITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16AAMDCAPP, BAG3, GORASP2, ACY3, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLAUR_AAMDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLAURQ03405DB00009AlteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00029AnistreplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00031TenecteplaseUrokinase plasminogen activator surface receptorbiotechapproved
HgenePLAURQ03405DB00015ReteplaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational
HgenePLAURQ03405DB00013UrokinaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for PLAUR_AAMDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLAURC0004352Autistic Disorder2CTD_human
HgenePLAURC0021368Inflammation1CTD_human
HgenePLAURC0027626Neoplasm Invasiveness1CTD_human
HgenePLAURC0027627Neoplasm Metastasis1CTD_human
HgenePLAURC0033578Prostatic Neoplasms1CTD_human
HgenePLAURC3495559Juvenile arthritis1CTD_human