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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27453

FusionGeneSummary for PLAC1_PAX5

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAC1_PAX5
Fusion gene ID: 27453
HgeneTgene
Gene symbol

PLAC1

PAX5

Gene ID

10761

5079

Gene nameplacenta specific 1paired box 5
SynonymsCT92|OOSP2LALL3|BSAP
Cytomap

Xq26.3

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionplacenta-specific protein 1cancer/testis antigen 92paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
Modification date2018051920180520
UniProtAcc

Q9HBJ0

Q02548

Ensembl transtripts involved in fusion geneENST00000476971, ENST00000359237, 
ENST00000358127, ENST00000523241, 
ENST00000520154, ENST00000377852, 
ENST00000377853, ENST00000522003, 
ENST00000520281, ENST00000414447, 
ENST00000523145, ENST00000446742, 
ENST00000377847, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 5 X 5=175
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLAC1 [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T12626PLAC1chrX

133742576

+PAX5chr9

36846928

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000476971ENST00000358127PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-3CDSENST00000476971ENST00000523241PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000520154PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000377852PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000377853PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000522003PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000520281PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000414447PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000523145PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000446742PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000476971ENST00000377847PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-3CDSENST00000359237ENST00000358127PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-3CDSENST00000359237ENST00000523241PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000520154PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000377852PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000377853PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000522003PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000520281PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000414447PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000523145PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000446742PLAC1chrX

133742576

+PAX5chr9

36846928

-
intron-intronENST00000359237ENST00000377847PLAC1chrX

133742576

+PAX5chr9

36846928

-

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FusionProtFeatures for PLAC1_PAX5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLAC1

Q9HBJ0

PAX5

Q02548

May play a role in placental development.{ECO:0000269|PubMed:10995572}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLAC1_PAX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLAC1_PAX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLAC1_PAX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLAC1_PAX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
TgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human