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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27444

FusionGeneSummary for PLA2G6_MAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G6_MAP4
Fusion gene ID: 27444
HgeneTgene
Gene symbol

PLA2G6

MAP4

Gene ID

8398

4134

Gene namephospholipase A2 group VImicrotubule associated protein 4
SynonymsCaI-PLA2|GVI|INAD1|IPLA2-VIA|NBIA2|NBIA2A|NBIA2B|PARK14|PLA2|PNPLA9|iPLA2|iPLA2beta-
Cytomap

22q13.1

3p21.31

Type of geneprotein-codingprotein-coding
Description85/88 kDa calcium-independent phospholipase A285 kDa calcium-independent phospholipase A2GVI PLA2iPLA2-betaintracellular membrane-associated calcium-independent phospholipase A2 betaneurodegeneration with brain iron accumulation 2patatin-like phosphmicrotubule-associated protein 4MAP-4
Modification date2018052220180523
UniProtAcc

O60733

P27816

Ensembl transtripts involved in fusion geneENST00000332509, ENST00000335539, 
ENST00000402064, ENST00000490473, 
ENST00000436218, ENST00000447598, 
ENST00000435484, ENST00000417303, 
ENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
Fusion gene scores* DoF score6 X 6 X 5=1807 X 10 X 3=210
# samples 710
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLA2G6 [Title/Abstract] AND MAP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G6

GO:0019731

antibacterial humoral response

18714013


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ300191PLA2G6chr22

38523889

-MAP4chr3

47917174

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000332509ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000332509ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000335539ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000402064ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000490473ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000436218ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000447598ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000435484ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000383737PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000395734PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000426837PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000360240PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000439356PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000264724PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000420772PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000441748PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000462206PLA2G6chr22

38523889

-MAP4chr3

47917174

+
intron-intronENST00000417303ENST00000434267PLA2G6chr22

38523889

-MAP4chr3

47917174

+

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FusionProtFeatures for PLA2G6_MAP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLA2G6

O60733

MAP4

P27816

Catalyzes the release of fatty acids from phospholipids.It has been implicated in normal phospholipid remodeling, nitricoxide-induced or vasopressin-induced arachidonic acid release andin leukotriene and prostaglandin production. May participate infas mediated apoptosis and in regulating transmembrane ion flux inglucose-stimulated B-cells. Has a role in cardiolipin (CL)deacylation. Required for both speed and directionality ofmonocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2,which lack the catalytic domain, are probably involved in thenegative regulation of iPLA2 activity. Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLA2G6_MAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLA2G6_MAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PLA2G6_MAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePLA2G6O60733DB01103Quinacrine85/88 kDa calcium-independent phospholipase A2small moleculeapproved|investigational
TgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for PLA2G6_MAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLA2G6C0270724Infantile Neuroaxonal Dystrophy2CTD_human;ORPHANET;UNIPROT
HgenePLA2G6C0005586Bipolar Disorder1PSYGENET
HgenePLA2G6C0027960Nevus1CTD_human
HgenePLA2G6C0033975Psychotic Disorders1PSYGENET
HgenePLA2G6C0036341Schizophrenia1PSYGENET
HgenePLA2G6C0349204Nonorganic psychosis1PSYGENET
HgenePLA2G6C1857747NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2 (disorder)1CTD_human;UNIPROT
HgenePLA2G6C2751842PARKINSON DISEASE 14, AUTOSOMAL RECESSIVE1CTD_human;ORPHANET;UNIPROT
TgeneMAP4C0043094Weight Gain1CTD_human