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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27429

FusionGeneSummary for PLA2G15_CD82

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G15_CD82
Fusion gene ID: 27429
HgeneTgene
Gene symbol

PLA2G15

CD82

Gene ID

23659

3732

Gene namephospholipase A2 group XVCD82 molecule
SynonymsACS|GXVPLA2|LLPL|LPLA2|LYPLA34F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27
Cytomap

16q22.1

11p11.2

Type of geneprotein-codingprotein-coding
Descriptiongroup XV phospholipase A21-O-acylceramide synthaseLCAT-like lysophospholipaselysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2CD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27
Modification date2018052420180523
UniProtAcc

Q8NCC3

P27701

Ensembl transtripts involved in fusion geneENST00000413021, ENST00000219345, 
ENST00000566188, ENST00000444212, 
ENST00000568599, 
ENST00000227155, 
ENST00000342935, ENST00000530931, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 3 X 4=60
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLA2G15 [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G15

GO:0006650

glycerophospholipid metabolic process

20410020

HgenePLA2G15

GO:0006672

ceramide metabolic process

20410020


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN480826PLA2G15chr16

68294413

-CD82chr11

44638370

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000413021ENST00000227155PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000413021ENST00000342935PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000413021ENST00000530931PLA2G15chr16

68294413

-CD82chr11

44638370

-
3UTR-intronENST00000219345ENST00000227155PLA2G15chr16

68294413

-CD82chr11

44638370

-
3UTR-intronENST00000219345ENST00000342935PLA2G15chr16

68294413

-CD82chr11

44638370

-
3UTR-intronENST00000219345ENST00000530931PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000566188ENST00000227155PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000566188ENST00000342935PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000566188ENST00000530931PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000444212ENST00000227155PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000444212ENST00000342935PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000444212ENST00000530931PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000568599ENST00000227155PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000568599ENST00000342935PLA2G15chr16

68294413

-CD82chr11

44638370

-
intron-intronENST00000568599ENST00000530931PLA2G15chr16

68294413

-CD82chr11

44638370

-

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FusionProtFeatures for PLA2G15_CD82


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLA2G15

Q8NCC3

CD82

P27701

Has transacylase and calcium-independent phospholipaseA2 activity (PubMed:20410020, PubMed:23958596). Catalyzes theformation of 1-O-acyl-N-acetylsphingosine and the concomitantrelease of a lyso-phospholipid (PubMed:11790796, PubMed:25727495).Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine(DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation inalveolar and peritoneal macrophages and in spleen (By similarity).May have weak lysophospholipase activity (PubMed:10092508).{ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:10092508,ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020,ECO:0000269|PubMed:23958596, ECO:0000269|PubMed:25727495}. Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLA2G15_CD82


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLA2G15_CD82


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLA2G15_CD82


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLA2G15_CD82


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD82C0000786Spontaneous abortion1CTD_human
TgeneCD82C0027626Neoplasm Invasiveness1CTD_human
TgeneCD82C0027627Neoplasm Metastasis1CTD_human