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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 274

FusionGeneSummary for ABLIM1_WDR11-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABLIM1_WDR11-AS1
Fusion gene ID: 274
HgeneTgene
Gene symbol

ABLIM1

WDR11-AS1

Gene ID

3983

283089

Gene nameactin binding LIM protein 1WDR11 antisense RNA 1
SynonymsABLIM|LIMAB1|LIMATIN|abLIM-1-
Cytomap

10q25.3

10q26.12

Type of geneprotein-codingncRNA
Descriptionactin-binding LIM protein 1actin-binding LIM protein family member 1actin-binding double-zinc-finger proteinWDR11 antisense RNA 1 (non-protein coding)
Modification date2018052320180329
UniProtAcc

O14639

Ensembl transtripts involved in fusion geneENST00000369252, ENST00000533213, 
ENST00000277895, ENST00000369266, 
ENST00000392952, ENST00000369253, 
ENST00000477638, 
ENST00000598981, 
ENST00000451706, ENST00000456120, 
ENST00000610133, ENST00000608667, 
Fusion gene scores* DoF score7 X 7 X 3=1471 X 1 X 1=1
# samples 71
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ABLIM1 [Title/Abstract] AND WDR11-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI828247ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369252ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000369252ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000369252ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000369252ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000369252ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000533213ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000533213ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000533213ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000533213ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000533213ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000277895ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000277895ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000277895ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000277895ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
5CDS-intronENST00000277895ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369266ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369266ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369266ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369266ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369266ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000392952ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000392952ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000392952ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000392952ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000392952ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369253ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369253ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369253ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369253ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000369253ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000477638ENST00000598981ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000477638ENST00000451706ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000477638ENST00000456120ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000477638ENST00000610133ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-
intron-intronENST00000477638ENST00000608667ABLIM1chr10

116331056

-WDR11-AS1chr10

122583134

-

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FusionProtFeatures for ABLIM1_WDR11-AS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABLIM1

O14639

WDR11-AS1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABLIM1_WDR11-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABLIM1_WDR11-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABLIM1_WDR11-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABLIM1_WDR11-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABLIM1C0236969Substance-Related Disorders1CTD_human