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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27384

FusionGeneSummary for PKM_MORN2

check button Fusion gene summary
Fusion gene informationFusion gene name: PKM_MORN2
Fusion gene ID: 27384
HgeneTgene
Gene symbol

PKM

MORN2

Gene ID

5315

729967

Gene namepyruvate kinase M1/2MORN repeat containing 2
SynonymsCTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1BLOCK27|MOPT
Cytomap

15q23

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionpyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, muscleMORN repeat-containing protein 2MORN motif protein in testisprotein containing single MORN motif in testis
Modification date2018052720180519
UniProtAcc

P14618

Q502X0

Ensembl transtripts involved in fusion geneENST00000319622, ENST00000565184, 
ENST00000389093, ENST00000335181, 
ENST00000568883, ENST00000449901, 
ENST00000565154, ENST00000568459, 
ENST00000340556, ENST00000410014, 
ENST00000409665, ENST00000409077, 
ENST00000409131, 
Fusion gene scores* DoF score17 X 21 X 3=10712 X 2 X 2=8
# samples 212
** MAII scorelog2(21/1071*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PKM [Title/Abstract] AND MORN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKM

GO:0012501

programmed cell death

17308100


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM554547PKMchr15

72491714

-MORN2chr2

39108581

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000319622ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000319622ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000319622ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000319622ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000319622ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565184ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565184ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565184ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000565184ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000565184ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000389093ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000389093ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000389093ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000389093ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000389093ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000335181ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000335181ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000335181ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000335181ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000335181ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568883ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568883ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568883ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000568883ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000568883ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000449901ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000449901ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000449901ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000449901ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000449901ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565154ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565154ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000565154ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000565154ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000565154ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568459ENST00000340556PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568459ENST00000410014PKMchr15

72491714

-MORN2chr2

39108581

+
intron-3CDSENST00000568459ENST00000409665PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000568459ENST00000409077PKMchr15

72491714

-MORN2chr2

39108581

+
intron-intronENST00000568459ENST00000409131PKMchr15

72491714

-MORN2chr2

39108581

+

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FusionProtFeatures for PKM_MORN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKM

P14618

MORN2

Q502X0

Might have a role in spermatogenesis.{ECO:0000250|UniProtKB:Q6UL01}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKM_MORN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKM_MORN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PKM_MORN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePKMP14618DB11638ArtenimolPyruvate kinase PKMsmall moleculeapproved|investigational

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RelatedDiseases for PKM_MORN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePKMC0027626Neoplasm Invasiveness2CTD_human
HgenePKMC0024667Animal Mammary Neoplasms1CTD_human
HgenePKMC0024668Mammary Neoplasms, Experimental1CTD_human
HgenePKMC0029456Osteoporosis1CTD_human
HgenePKMC2239176Liver carcinoma1CTD_human