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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27374

FusionGeneSummary for PKMYT1_PAQR4

check button Fusion gene summary
Fusion gene informationFusion gene name: PKMYT1_PAQR4
Fusion gene ID: 27374
HgeneTgene
Gene symbol

PKMYT1

PAQR4

Gene ID

9088

124222

Gene nameprotein kinase, membrane associated tyrosine/threonine 1progestin and adipoQ receptor family member 4
SynonymsMYT1|PPP1R126-
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasemyt1 kinaseprotein phosphatase 1, regulatory subunit 126progestin and adipoQ receptor family member 4progestin and adipoQ receptor family member IV
Modification date2018052320180519
UniProtAcc

Q99640

Q8N4S7

Ensembl transtripts involved in fusion geneENST00000571102, ENST00000431515, 
ENST00000440027, ENST00000262300, 
ENST00000574385, ENST00000574730, 
ENST00000573944, 
ENST00000318782, 
ENST00000293978, ENST00000576565, 
ENST00000572687, ENST00000574988, 
Fusion gene scores* DoF score3 X 4 X 4=483 X 3 X 1=9
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PKMYT1 [Title/Abstract] AND PAQR4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKMYT1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF014118PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000571102ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000571102ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000571102ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000571102ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000571102ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000431515ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000431515ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000431515ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000431515ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000431515ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000440027ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000440027ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000440027ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000440027ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000440027ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000262300ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000262300ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000262300ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000262300ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000262300ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574385ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574385ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574385ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574385ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574385ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574730ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574730ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574730ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574730ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000574730ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000573944ENST00000318782PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000573944ENST00000293978PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000573944ENST00000576565PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000573944ENST00000572687PKMYT1chr16

3030464

+PAQR4chr16

3030309

-
intron-intronENST00000573944ENST00000574988PKMYT1chr16

3030464

+PAQR4chr16

3030309

-

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FusionProtFeatures for PKMYT1_PAQR4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKMYT1

Q99640

PAQR4

Q8N4S7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKMYT1_PAQR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKMYT1_PAQR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKMYT1_PAQR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PKMYT1_PAQR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePKMYT1C0025202melanoma1CTD_human