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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 27370

FusionGeneSummary for PKIG_PKIG

check button Fusion gene summary
Fusion gene informationFusion gene name: PKIG_PKIG
Fusion gene ID: 27370
HgeneTgene
Gene symbol

PKIG

PKIG

Gene ID

11142

11142

Gene namecAMP-dependent protein kinase inhibitor gammacAMP-dependent protein kinase inhibitor gamma
SynonymsPKI-gammaPKI-gamma
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase inhibitor gammaprotein kinase (cAMP-dependent, catalytic) inhibitor gammacAMP-dependent protein kinase inhibitor gammaprotein kinase (cAMP-dependent, catalytic) inhibitor gamma
Modification date2018052320180523
UniProtAcc

Q9Y2B9

Q9Y2B9

Ensembl transtripts involved in fusion geneENST00000372891, ENST00000372894, 
ENST00000372892, ENST00000372889, 
ENST00000372887, ENST00000372882, 
ENST00000477390, ENST00000372886, 
ENST00000349959, 		ENST00000372891, 
ENST00000372894, ENST00000372892, 
ENST00000372889, ENST00000372887, 
ENST00000372882, ENST00000477390, 
ENST00000372886, ENST00000349959, 
Fusion gene scores* DoF score3 X 4 X 3=364 X 4 X 4=64
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKIG [Title/Abstract] AND PKIG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA603416PKIGchr20

43246030

+PKIGchr20

43245949

-
ChiTaRS3.1AW974374PKIGchr20

43247669

+PKIGchr20

43247530

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000372891ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372891ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372894ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372892ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372889ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372887ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372882ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000477390ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000372886ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372891PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372894PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372892PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372889PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372887PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372882PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000477390PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000372886PKIGchr20

43246030

+PKIGchr20

43245949

-
intron-intronENST00000349959ENST00000349959PKIGchr20

43246030

+PKIGchr20

43245949

-
3UTR-3UTRENST00000372891ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372891ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372891ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372891ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372891ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372891ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372891ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372891ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372891ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372894ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372894ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372894ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372894ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372892ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372892ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372892ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372892ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372889ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372889ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372889ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372889ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372887ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372887ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372887ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372887ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372882ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372882ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000372882ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000372882ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000477390ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000477390ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-intronENST00000477390ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
intron-3UTRENST00000477390ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372886ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372886ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000372886ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000372886ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000372891PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000372894PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000372892PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000372889PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000349959ENST00000372887PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000349959ENST00000372882PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-intronENST00000349959ENST00000477390PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000372886PKIGchr20

43247669

+PKIGchr20

43247530

-
3UTR-3UTRENST00000349959ENST00000349959PKIGchr20

43247669

+PKIGchr20

43247530

-

Top

FusionProtFeatures for PKIG_PKIG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKIG

Q9Y2B9

PKIG

Q9Y2B9

Extremely potent competitive inhibitor of cAMP-dependentprotein kinase activity, this protein interacts with the catalyticsubunit of the enzyme after the cAMP-induced dissociation of itsregulatory chains. {ECO:0000250}. Extremely potent competitive inhibitor of cAMP-dependentprotein kinase activity, this protein interacts with the catalyticsubunit of the enzyme after the cAMP-induced dissociation of itsregulatory chains. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKIG_PKIG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKIG_PKIG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKIG_PKIG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PKIG_PKIG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource