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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27367

FusionGeneSummary for PKIB_SLC35F1

check button Fusion gene summary
Fusion gene informationFusion gene name: PKIB_SLC35F1
Fusion gene ID: 27367
HgeneTgene
Gene symbol

PKIB

SLC35F1

Gene ID

5570

222553

Gene namecAMP-dependent protein kinase inhibitor betasolute carrier family 35 member F1
SynonymsPRKACN2C6orf169|dJ230I3.1
Cytomap

6q22.31

6q22.2-q22.31

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase inhibitor betaPKI-betacAMP-dependent protein kinase inhibitor 2protein kinase (cAMP-dependent, catalytic) inhibitor betasolute carrier family 35 member F1
Modification date2018052320180519
UniProtAcc

Q9C010

Q5T1Q4

Ensembl transtripts involved in fusion geneENST00000392491, ENST00000607474, 
ENST00000368452, ENST00000368448, 
ENST00000392490, ENST00000258014, 
ENST00000354275, ENST00000368446, 
ENST00000360388, 
Fusion gene scores* DoF score4 X 2 X 3=246 X 5 X 5=150
# samples 36
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKIB [Title/Abstract] AND SLC35F1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A06R-01APKIBchr6

122954512

+SLC35F1chr6

118556672

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000392491ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
intron-3CDSENST00000607474ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
5UTR-3CDSENST00000368452ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
5UTR-3CDSENST00000368448ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
5UTR-3CDSENST00000392490ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
intron-3CDSENST00000258014ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
intron-3CDSENST00000354275ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+
intron-3CDSENST00000368446ENST00000360388PKIBchr6

122954512

+SLC35F1chr6

118556672

+

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FusionProtFeatures for PKIB_SLC35F1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKIB

Q9C010

SLC35F1

Q5T1Q4

Extremely potent competitive inhibitor of cAMP-dependentprotein kinase activity, this protein interacts with the catalyticsubunit of the enzyme after the cAMP-induced dissociation of itsregulatory chains. {ECO:0000250}. Putative solute transporter. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKIB_SLC35F1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKIB_SLC35F1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PKIBE2F1, E2F3, PIN1, LY6D, NLGN3SLC35F1VIPR2, HTR2C, ATP5B, NPY2R


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKIB_SLC35F1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PKIB_SLC35F1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource