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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2736

FusionGeneSummary for ARL6IP4_LIG1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL6IP4_LIG1
Fusion gene ID: 2736
HgeneTgene
Gene symbol

ARL6IP4

LIG1

Gene ID

51329

26018

Gene nameADP ribosylation factor like GTPase 6 interacting protein 4leucine rich repeats and immunoglobulin like domains 1
SynonymsSFRS20|SR-25|SRp25|SRrp37LIG-1|LIG1
Cytomap

12q24.31

3p14.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 6-interacting protein 4ADP-ribosylation factor GTPase 6 interacting protein 4ADP-ribosylation factor-like 6 interacting protein 4ADP-ribosylation-like factor 6 interacting protein 4ARL-6-interacting protein 4HSP-9leucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1
Modification date2018051920180523
UniProtAcc

Q66PJ3

P18858

Ensembl transtripts involved in fusion geneENST00000543566, ENST00000315580, 
ENST00000392435, ENST00000426960, 
ENST00000453766, ENST00000454885, 
ENST00000412505, ENST00000439686, 
ENST00000357866, 
ENST00000263274, 
ENST00000536218, ENST00000427526, 
ENST00000599165, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 4=144
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL6IP4 [Title/Abstract] AND LIG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG979982ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000543566ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000543566ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000543566ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000543566ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000315580ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000315580ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000315580ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000315580ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000392435ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000392435ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000392435ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000392435ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000426960ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000426960ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000426960ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000426960ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000453766ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000453766ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000453766ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000453766ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000454885ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000454885ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000454885ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000454885ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000412505ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000412505ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000412505ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000412505ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000439686ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000439686ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000439686ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000439686ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000357866ENST00000263274ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000357866ENST00000536218ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000357866ENST00000427526ARL6IP4chr12

123466595

+LIG1chr19

48668878

-
5CDS-5UTRENST00000357866ENST00000599165ARL6IP4chr12

123466595

+LIG1chr19

48668878

-

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FusionProtFeatures for ARL6IP4_LIG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARL6IP4

Q66PJ3

LIG1

P18858

DNA ligase that seals nicks in double-stranded DNAduring DNA replication, DNA recombination and DNA repair.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARL6IP4_LIG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARL6IP4_LIG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARL6IP4_LIG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLIG1P18858DB00290BleomycinDNA ligase 1small moleculeapproved|investigational

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RelatedDiseases for ARL6IP4_LIG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLIG1C0005695Bladder Neoplasm1CTD_human