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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27267

FusionGeneSummary for PIP4K2B_SLC6A4

check button Fusion gene summary
Fusion gene informationFusion gene name: PIP4K2B_SLC6A4
Fusion gene ID: 27267
HgeneTgene
Gene symbol

PIP4K2B

SLC6A4

Gene ID

8396

6532

Gene namephosphatidylinositol-5-phosphate 4-kinase type 2 betasolute carrier family 6 member 4
SynonymsPI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta|PIP5P4KB5-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|SERT1|hSERT
Cytomap

17q12

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 5-phosphate 4-kinase type-2 beta1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinasePI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidylisodium-dependent serotonin transporter5-hydroxytryptamine (serotonin) transporter5HT transporterNa+/Cl- dependent serotonin transporterserotonin transporter 1solute carrier family 6 (neurotransmitter transporter), member 4solute carrier family 6 (ne
Modification date2018051920180527
UniProtAcc

P78356

P31645

Ensembl transtripts involved in fusion geneENST00000269554, ENST00000311500, 
ENST00000401766, ENST00000261707, 
Fusion gene scores* DoF score14 X 9 X 4=5044 X 2 X 4=32
# samples 154
** MAII scorelog2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIP4K2B [Title/Abstract] AND SLC6A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC6A4

GO:0006837

serotonin transport

19270731

TgeneSLC6A4

GO:0009636

response to toxic substance

17575980

TgeneSLC6A4

GO:0015844

monoamine transport

16024787

TgeneSLC6A4

GO:0051610

serotonin uptake

8987735|16870614|17506858|18227069|19270731


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A2FB-01APIP4K2Bchr17

36943076

-SLC6A4chr17

28549933

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269554ENST00000401766PIP4K2Bchr17

36943076

-SLC6A4chr17

28549933

-
5CDS-5UTRENST00000269554ENST00000261707PIP4K2Bchr17

36943076

-SLC6A4chr17

28549933

-
5UTR-intronENST00000311500ENST00000401766PIP4K2Bchr17

36943076

-SLC6A4chr17

28549933

-
5UTR-5UTRENST00000311500ENST00000261707PIP4K2Bchr17

36943076

-SLC6A4chr17

28549933

-

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FusionProtFeatures for PIP4K2B_SLC6A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIP4K2B

P78356

SLC6A4

P31645

Participates in the biosynthesis of phosphatidylinositol4,5-bisphosphate. {ECO:0000269|PubMed:9038203}. Serotonin transporter whose primary function in thecentral nervous system involves the regulation of serotonergicsignaling via transport of serotonin molecules from the synapticcleft back into the pre-synaptic terminal for re-utilization.Plays a key role in mediating regulation of the availability ofserotonin to other receptors of serotonergic systems. Terminatesthe action of serotonin and recycles it in a sodium-dependentmanner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069,ECO:0000269|PubMed:19270731, ECO:0000269|PubMed:27049939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIP4K2B_SLC6A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIP4K2B_SLC6A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIP4K2BTNFRSF1A, PIP4K2B, SPOP, UBQLN4, MED18, CSNK2A2, HMBOX1, ARL6IP4, EAF1, ZRANB2, EPB41L3, LIN7A, DDX23, MYL9, PRPF8, SKP1, MED4, CLK1, CEP19, PIP4K2A, HIF1AN, LZTS2, ARHGAP22, AHCYL2, GPBP1L1, SPRY4, PRICKLE3, ZNF428, TULP3, TMEM194A, SUN2SLC6A4STX1A, CANX, CALR, SNCA, SNCG, HSPA1A, HSPA8, HSP90AB1, STIP1, STUB1, PTGES3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIP4K2B_SLC6A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC6A4P31645DB00215CitalopramSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00285VenlafaxineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00289AtomoxetineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00321AmitriptylineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00344ProtriptylineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00370MirtazapineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00408LoxapineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00454PethidineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00458ImipramineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00476DuloxetineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00514DextromethorphanSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00540NortriptylineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00543AmoxapineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00661VerapamilSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00726TrimipramineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00805MinaprineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00852PseudoephedrineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00988DopamineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB01104SertralineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB01114ChlorphenamineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB06204TapentadolSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB09016ButriptylineSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB09167DosulepinSodium-dependent serotonin transportersmall moleculeapproved
TgeneSLC6A4P31645DB00191PhentermineSodium-dependent serotonin transportersmall moleculeapproved|illicit
TgeneSLC6A4P31645DB00907CocaineSodium-dependent serotonin transportersmall moleculeapproved|illicit
TgeneSLC6A4P31645DB01577MethamphetamineSodium-dependent serotonin transportersmall moleculeapproved|illicit
TgeneSLC6A4P31645DB00182AmphetamineSodium-dependent serotonin transportersmall moleculeapproved|illicit|investigational
TgeneSLC6A4P31645DB00574FenfluramineSodium-dependent serotonin transportersmall moleculeapproved|illicit|investigational|withdrawn
TgeneSLC6A4P31645DB01105SibutramineSodium-dependent serotonin transportersmall moleculeapproved|illicit|investigational|withdrawn
TgeneSLC6A4P31645DB01191DexfenfluramineSodium-dependent serotonin transportersmall moleculeapproved|illicit|investigational|withdrawn
TgeneSLC6A4P31645DB00176FluvoxamineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB00193TramadolSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB00422MethylphenidateSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB00579MazindolSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB00656TrazodoneSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB00715ParoxetineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB01142DoxepinSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB01151DesipramineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB01175EscitalopramSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB04896MilnacipranSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB06148MianserinSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB06700DesvenlafaxineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB06701DexmethylphenidateSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB09068VortioxetineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB09289TianeptineSodium-dependent serotonin transportersmall moleculeapproved|investigational
TgeneSLC6A4P31645DB01242ClomipramineSodium-dependent serotonin transportersmall moleculeapproved|investigational|vet_approved
TgeneSLC6A4P31645DB09225ZotepineSodium-dependent serotonin transportersmall moleculeapproved|investigational|withdrawn
TgeneSLC6A4P31645DB00472FluoxetineSodium-dependent serotonin transportersmall moleculeapproved|vet_approved
TgeneSLC6A4P31645DB01149NefazodoneSodium-dependent serotonin transportersmall moleculeapproved|withdrawn

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RelatedDiseases for PIP4K2B_SLC6A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC6A4C0011581Depressive disorder9CTD_human;PSYGENET
TgeneSLC6A4C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
TgeneSLC6A4C0005586Bipolar Disorder7CTD_human;PSYGENET
TgeneSLC6A4C0525045Mood Disorders6CTD_human;PSYGENET
TgeneSLC6A4C1269683Major Depressive Disorder6CTD_human;PSYGENET
TgeneSLC6A4C0004352Autistic Disorder5CTD_human
TgeneSLC6A4C0011570Mental Depression5PSYGENET
TgeneSLC6A4C0025193Melancholia5PSYGENET
TgeneSLC6A4C0041696Unipolar Depression5PSYGENET
TgeneSLC6A4C0085159Seasonal Affective Disorder5PSYGENET
TgeneSLC6A4C0221074Depression, Postpartum5PSYGENET
TgeneSLC6A4C0344315Depressed mood5PSYGENET
TgeneSLC6A4C0581391Chronic depression4PSYGENET
TgeneSLC6A4C0600427Cocaine Dependence4PSYGENET
TgeneSLC6A4C0221480Recurrent depression3PSYGENET
TgeneSLC6A4C0233477Dysphoric mood3PSYGENET
TgeneSLC6A4C2063866Depressive Disorder, Treatment-Resistant3PSYGENET
TgeneSLC6A4C0001723Affective Disorders, Psychotic2PSYGENET
TgeneSLC6A4C0005587Depression, Bipolar2PSYGENET
TgeneSLC6A4C0025261Memory Disorders2CTD_human
TgeneSLC6A4C0085762Alcohol abuse2PSYGENET
TgeneSLC6A4C0178417Anhedonia2PSYGENET
TgeneSLC6A4C0338715Drug-induced depressive state2PSYGENET
TgeneSLC6A4C0001969Alcoholic Intoxication1PSYGENET
TgeneSLC6A4C0003469Anxiety Disorders1CTD_human
TgeneSLC6A4C0009241Cognition Disorders1CTD_human
TgeneSLC6A4C0013415Dysthymic Disorder1PSYGENET
TgeneSLC6A4C0020542Pulmonary Hypertension1CTD_human
TgeneSLC6A4C0024809Marijuana Abuse1PSYGENET
TgeneSLC6A4C0028768Obsessive-Compulsive Disorder1CTD_human
TgeneSLC6A4C0031212Personality Disorders1CTD_human
TgeneSLC6A4C0036341Schizophrenia1CTD_human
TgeneSLC6A4C0038587Substance Withdrawal Syndrome1CTD_human
TgeneSLC6A4C0038644Sudden infant death syndrome1CTD_human
TgeneSLC6A4C0236733Amphetamine-Related Disorders1CTD_human
TgeneSLC6A4C0236736Cocaine-Related Disorders1CTD_human
TgeneSLC6A4C0236792Asperger Syndrome1CTD_human
TgeneSLC6A4C0236969Substance-Related Disorders1CTD_human
TgeneSLC6A4C0588008Severe depression1PSYGENET
TgeneSLC6A4C3160814Cannabis use1PSYGENET