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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27254

FusionGeneSummary for PIP4K2A_ITFG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIP4K2A_ITFG1
Fusion gene ID: 27254
HgeneTgene
Gene symbol

PIP4K2A

ITFG1

Gene ID

5305

81533

Gene namephosphatidylinositol-5-phosphate 4-kinase type 2 alphaintegrin alpha FG-GAP repeat containing 1
SynonymsPI5P4KA|PIP5K2A|PIP5KII-alpha|PIP5KIIA|PIPK2310047C21Rik|CDA08|LNKN-1|TIP
Cytomap

10p12.2

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 5-phosphate 4-kinase type-2 alpha1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha1-phosphatidylinositol-4-phosphate kinase1-phosphatidylinositol-4-phosphate-5-kinasePI(5)P 4-kinase type II alphaPIP4KII-alphaPIP5KIIIPIP5KIIalT-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1
Modification date2018052220180519
UniProtAcc

P48426

Q8TB96

Ensembl transtripts involved in fusion geneENST00000376573, ENST00000545335, 
ENST00000323883, ENST00000422321, 
ENST00000568047, ENST00000320640, 
ENST00000544001, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 3 X 5=90
# samples 55
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIP4K2A [Title/Abstract] AND ITFG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A8HC-01APIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000376573ENST00000568047PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000376573ENST00000320640PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000376573ENST00000544001PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000545335ENST00000568047PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000545335ENST00000320640PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000545335ENST00000544001PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000323883ENST00000568047PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000323883ENST00000320640PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000323883ENST00000544001PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
intron-5UTRENST00000422321ENST00000568047PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
intron-5UTRENST00000422321ENST00000320640PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-
intron-5UTRENST00000422321ENST00000544001PIP4K2Achr10

22839588

-ITFG1chr16

47196575

-

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FusionProtFeatures for PIP4K2A_ITFG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIP4K2A

P48426

ITFG1

Q8TB96

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositolring, to form phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2). May exert its function by regulating the levelsof PtdIns5P, which functions in the cytosol by increasing AKTactivity and in the nucleus signals through ING2. May regulate thepool of cytosolic PtdIns5P in response to the activation oftyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. Maybe involved in thrombopoiesis, and the terminal maturation ofmegakaryocytes and regulation of their size.{ECO:0000269|PubMed:18364242}. Modulator of T-cell function. Has a protective effect ingraft versus host disease model (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIP4K2A_ITFG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIP4K2A_ITFG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIP4K2AGRK5, GSTK1, CSNK2A2, ARL6IP4, EAF1, ZRANB2, EPB41L3, CSNK2A1, CSNK2B, DDX23, MTPN, PRPF8, SKP1, KRAS, IFI16, MED4, RPS6KB1, PIP4K2B, DIP2C, UBTF, AFF3, RTF1, AFF4, HDGFRP2, BRD3, MLLT3, PIP4K2C, PNISR, MEX3B, STRADA, MLLT1, AFF1, ELL3, BRD2, GPATCH8, CHD9, AHCYL2, STK11, BRD4, NAF1, GPALPP1, MEX3C, PIP5K1A, EAF2, BRPF1, GPBP1L1, ACIN1, SETD1B, RNPS1, ELL2, AHCYL1, KANK1, CWC22, LENG8, RAD18, PPRC1, STRADB, C12orf43, DNAJC13, PLCD3, NFKBIL1, CAB39, AP3B1, NOLC1, PNN, RFWD3, ELL, CLASRP, PPIG, JMJD6, CXXC1, SBF1, LZTS2, CCNT1, GTF2F1, IWS1, EDC4, SRSF8, C11orf31, ARHGAP22, TCOF1, SRRM2, CCDC102A, WDR26, AP3M1, C18orf25, PRICKLE3, SETD2, SPEN, TMEM194A, NOS1AP, MTMR1, CHD8, EPB41L5, PIN1, ST6GAL1, NKAP, CCDC9, RAB11FIP1, ZNF428, SUN2ITFG1HMOX2, MRPL44, CDC73, SERBP1, TAF1D, NUDT3, FAM118B, TNFRSF14, FBXO6, HLA-DPA1, CD1B, CEACAM21, HLA-C, PCDHGB1, TMEM30B, CDH5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIP4K2A_ITFG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIP4K2A_ITFG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIP4K2AC0036341Schizophrenia4PSYGENET
HgenePIP4K2AC0005586Bipolar Disorder3PSYGENET
HgenePIP4K2AC0025202melanoma1CTD_human