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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2725

FusionGeneSummary for ARL17A_STEAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL17A_STEAP4
Fusion gene ID: 2725
HgeneTgene
Gene symbol

ARL17A

STEAP4

Gene ID

100506084

79689

Gene nameADP ribosylation factor like GTPase 17BSTEAP4 metalloreductase
SynonymsARL17|ARL17ASTAMP2|SchLAH|TIARP|TNFAIP9
Cytomap

17q21.31

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 17ADP-ribosylation factor 7ADP-ribosylation factor-like 17Bmetalloreductase STEAP4STEAP family member 4seven chromosome locus associated with HCCsix transmembrane prostate protein 2six-transmembrane epithelial antigen of prostate 4sixTransMembrane protein of prostate 2tumor necrosis factor, alpha-induced pr
Modification date2018040320180523
UniProtAcc

Q8IVW1

Q687X5

Ensembl transtripts involved in fusion geneENST00000445552, ENST00000337845, 
ENST00000329240, ENST00000573185, 
ENST00000570550, ENST00000336125, 
ENST00000549904, ENST00000550273, 
ENST00000549665, ENST00000553155, 
ENST00000380079, ENST00000301959, 
ENST00000414498, 
Fusion gene scores* DoF score7 X 8 X 1=561 X 1 X 1=1
# samples 81
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ARL17A [Title/Abstract] AND STEAP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG679330ARL17Achr17

1207169

-STEAP4chr7

87907029

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000445552ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000445552ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000445552ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000337845ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000337845ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000337845ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000329240ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000329240ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000329240ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000573185ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000573185ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000573185ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000570550ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000570550ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000570550ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000336125ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000336125ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000336125ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000549904ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000549904ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000549904ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000550273ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000550273ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000550273ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000549665ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000549665ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000549665ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-3UTRENST00000553155ENST00000380079ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000553155ENST00000301959ARL17Achr17

1207169

-STEAP4chr7

87907029

-
intron-intronENST00000553155ENST00000414498ARL17Achr17

1207169

-STEAP4chr7

87907029

-

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FusionProtFeatures for ARL17A_STEAP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARL17A

Q8IVW1

STEAP4

Q687X5

GTP-binding protein that functions as an allostericactivator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulatevesicle budding and uncoating within the Golgi apparatus (Bysimilarity). {ECO:0000250}. Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). UsesNADP(+) as acceptor (By similarity). Plays a role in systemicmetabolic homeostasis, integrating inflammatory and metabolicresponses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved ininflammatory arthritis, through the regulation of inflammatorycytokines (PubMed:19660107). Inhibits anchorage-independent cellproliferation (PubMed:19787193). {ECO:0000250,ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367,ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARL17A_STEAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARL17A_STEAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARL17A_STEAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARL17A_STEAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTEAP4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSTEAP4C0033578Prostatic Neoplasms1CTD_human