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Fusion gene ID: 2725 |
FusionGeneSummary for ARL17A_STEAP4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARL17A_STEAP4 | Fusion gene ID: 2725 | Hgene | Tgene | Gene symbol | ARL17A | STEAP4 | Gene ID | 100506084 | 79689 |
Gene name | ADP ribosylation factor like GTPase 17B | STEAP4 metalloreductase | |
Synonyms | ARL17|ARL17A | STAMP2|SchLAH|TIARP|TNFAIP9 | |
Cytomap | 17q21.31 | 7q21.12 | |
Type of gene | protein-coding | protein-coding | |
Description | ADP-ribosylation factor-like protein 17ADP-ribosylation factor 7ADP-ribosylation factor-like 17B | metalloreductase STEAP4STEAP family member 4seven chromosome locus associated with HCCsix transmembrane prostate protein 2six-transmembrane epithelial antigen of prostate 4sixTransMembrane protein of prostate 2tumor necrosis factor, alpha-induced pr | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | Q8IVW1 | Q687X5 | |
Ensembl transtripts involved in fusion gene | ENST00000445552, ENST00000337845, ENST00000329240, ENST00000573185, ENST00000570550, ENST00000336125, ENST00000549904, ENST00000550273, ENST00000549665, ENST00000553155, | ENST00000380079, ENST00000301959, ENST00000414498, | |
Fusion gene scores | * DoF score | 7 X 8 X 1=56 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ARL17A [Title/Abstract] AND STEAP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG679330 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000445552 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000445552 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000445552 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000337845 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000337845 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000337845 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000329240 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000329240 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000329240 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000573185 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000573185 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000573185 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000570550 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000570550 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000570550 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000336125 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000336125 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000336125 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000549904 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000549904 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000549904 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000550273 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000550273 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000550273 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000549665 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000549665 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000549665 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-3UTR | ENST00000553155 | ENST00000380079 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000553155 | ENST00000301959 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
intron-intron | ENST00000553155 | ENST00000414498 | ARL17A | chr17 | 1207169 | - | STEAP4 | chr7 | 87907029 | - |
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FusionProtFeatures for ARL17A_STEAP4 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARL17A | STEAP4 |
GTP-binding protein that functions as an allostericactivator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulatevesicle budding and uncoating within the Golgi apparatus (Bysimilarity). {ECO:0000250}. | Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). UsesNADP(+) as acceptor (By similarity). Plays a role in systemicmetabolic homeostasis, integrating inflammatory and metabolicresponses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved ininflammatory arthritis, through the regulation of inflammatorycytokines (PubMed:19660107). Inhibits anchorage-independent cellproliferation (PubMed:19787193). {ECO:0000250,ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367,ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARL17A_STEAP4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARL17A_STEAP4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARL17A_STEAP4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARL17A_STEAP4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | STEAP4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | STEAP4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |