	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 2719

FusionGeneSummary for ARL17A_AGTRAP

Fusion gene summary

Fusion gene information	Fusion gene name: ARL17A_AGTRAP
	Fusion gene ID: 2719
		Hgene	Tgene
	Gene symbol	ARL17A	AGTRAP
	Gene ID	100506084	57085
	Gene name	ADP ribosylation factor like GTPase 17B	angiotensin II receptor associated protein
	Synonyms	ARL17\|ARL17A	ATRAP
	Cytomap	17q21.31	1p36.22
	Type of gene	protein-coding	protein-coding
	Description	ADP-ribosylation factor-like protein 17ADP-ribosylation factor 7ADP-ribosylation factor-like 17B	type-1 angiotensin II receptor-associated proteinAT1 receptor-associated proteinATI receptor-associated proteinangiotensin II, type I receptor-associated protein
	Modification date	20180403	20180519
	UniProtAcc	Q8IVW1	Q6RW13
	Ensembl transtripts involved in fusion gene	ENST00000445552, ENST00000337845, ENST00000329240, ENST00000573185, ENST00000570550, ENST00000336125, ENST00000549904, ENST00000550273, ENST00000549665, ENST00000553155,	ENST00000376637, ENST00000400895, ENST00000491346, ENST00000376629, ENST00000376627, ENST00000314340, ENST00000452018, ENST00000510878,
Fusion gene scores	* DoF score	7 X 8 X 1=56	3 X 2 X 3=18
	# samples	8	3
	** MAII score	log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARL17A [Title/Abstract] AND AGTRAP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ335717	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000445552	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000445552	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000337845	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000329240	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000573185	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000570550	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000336125	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549904	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000550273	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000549665	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000376637	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000400895	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000491346	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000376629	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000376627	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000314340	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000452018	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-
intron-intron	ENST00000553155	ENST00000510878	ARL17A	chr17	751508	-	AGTRAP	chr1	11803178	-

Top

FusionProtFeatures for ARL17A_AGTRAP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARL17A Q8IVW1	AGTRAP Q6RW13
GTP-binding protein that functions as an allostericactivator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulatevesicle budding and uncoating within the Golgi apparatus (Bysimilarity). {ECO:0000250}.	Appears to be a negative regulator of type-1 angiotensinII receptor-mediated signaling by regulating receptorinternalisation as well as mechanism of receptor desensitizationsuch as phosphorylation. Induces also a decrease in cellproliferation and angiotensin II-stimulated transcriptionalactivity. {ECO:0000269\|PubMed:12960423}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for ARL17A_AGTRAP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ARL17A_AGTRAP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for ARL17A_AGTRAP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for ARL17A_AGTRAP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 2719

FusionGeneSummary for ARL17A_AGTRAP

FusionProtFeatures for ARL17A_AGTRAP

FusionGeneSequence for ARL17A_AGTRAP

FusionGenePPI for ARL17A_AGTRAP

RelatedDrugs for ARL17A_AGTRAP

RelatedDiseases for ARL17A_AGTRAP