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Fusion gene ID: 27171 |
FusionGeneSummary for PIGW_POMGNT1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PIGW_POMGNT1 | Fusion gene ID: 27171 | Hgene | Tgene | Gene symbol | PIGW | POMGNT1 | Gene ID | 284098 | 55624 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class W | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | |
Synonyms | Gwt1|HPMRS5 | GNTI.2|GnT I.2|LGMD2O|MEB|MGAT1.2|RP76|gnT-I.2 | |
Cytomap | 17q12 | 1p34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol-glycan biosynthesis class W protein | protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7Z7B1 | Q8WZA1 | |
Ensembl transtripts involved in fusion gene | ENST00000592983, ENST00000328396, | ENST00000396420, ENST00000371984, ENST00000371992, ENST00000535522, ENST00000371986, ENST00000485714, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 2 | 4 | |
** MAII score | log2(2/1*10)=4.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PIGW [Title/Abstract] AND POMGNT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | POMGNT1 | GO:0006493 | protein O-linked glycosylation | 11709191 |
Tgene | POMGNT1 | GO:0016266 | O-glycan processing | 27493216 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI376808 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + | ||
ChiTaRS3.1 | AW272407 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000592983 | ENST00000396420 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
intron-intron | ENST00000592983 | ENST00000371984 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
intron-intron | ENST00000592983 | ENST00000371992 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
intron-intron | ENST00000592983 | ENST00000535522 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
intron-intron | ENST00000592983 | ENST00000371986 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
intron-5UTR | ENST00000592983 | ENST00000485714 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-intron | ENST00000328396 | ENST00000396420 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-intron | ENST00000328396 | ENST00000371984 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-intron | ENST00000328396 | ENST00000371992 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-intron | ENST00000328396 | ENST00000535522 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-intron | ENST00000328396 | ENST00000371986 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
3UTR-5UTR | ENST00000328396 | ENST00000485714 | PIGW | chr17 | 34894873 | - | POMGNT1 | chr1 | 46656022 | + |
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FusionProtFeatures for PIGW_POMGNT1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PIGW | POMGNT1 |
Required for the transport of GPI-anchored proteins tothe plasma membrane (PubMed:24367057). Probable acetyltransferase,which acetylates the inositol ring of phosphatidylinositol duringbiosynthesis of GPI-anchor. Acetylation during GPI-anchorbiosynthesis is not essential for the subsequent mannosylation andis usually removed soon after the attachment of GPIs to proteins(By similarity). {ECO:0000250|UniProtKB:Q7TSN4,ECO:0000269|PubMed:24367057}. | Participates in O-mannosyl glycosylation by catalyzingthe addition of N-acetylglucosamine to O-linked mannose onglycoproteins (PubMed:11709191, PubMed:27493216). Catalyzes thesynthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety onalpha-dystroglycan and other O-mannosylated proteins, providingthe necessary basis for the addition of further carbohydratemoieties (PubMed:11709191, PubMed:27493216). Is specific for alphalinked terminal mannose and does not have MGAT3, MGAT4, MGAT5,MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191,ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613,ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIGW_POMGNT1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PIGW_POMGNT1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIGW_POMGNT1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIGW_POMGNT1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PIGW | C4014958 | HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 5 | 1 | UNIPROT |
Tgene | POMGNT1 | C3151519 | MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 3 | 8 | UNIPROT |
Tgene | POMGNT1 | C3150412 | MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION), TYPE B, 3 | 5 | CTD_human;UNIPROT |
Tgene | POMGNT1 | C3150417 | MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 3 | 1 | CTD_human;ORPHANET;UNIPROT |