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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27161

FusionGeneSummary for PIGU_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGU_BCAS3
Fusion gene ID: 27161
HgeneTgene
Gene symbol

PIGU

BCAS3

Gene ID

128869

54828

Gene namephosphatidylinositol glycan anchor biosynthesis class UBCAS3, microtubule associated cell migration factor
SynonymsCDC91L1|GAB1GAOB1|MAAB
Cytomap

20q11.22

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-libreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

Q9H490

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000374820, ENST00000452740, 
ENST00000480175, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score13 X 8 X 8=83226 X 15 X 15=5850
# samples 1341
** MAII scorelog2(13/832*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGU [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIGU

GO:0006506

GPI anchor biosynthetic process

15034568

HgenePIGU

GO:0046425

regulation of JAK-STAT cascade

15034568

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A62V-01APIGUchr20

33231968

-BCAS3chr17

59445688

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000374820ENST00000589222PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000407086PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000390652PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000408905PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000588462PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000585744PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000374820ENST00000588874PIGUchr20

33231968

-BCAS3chr17

59445688

+
5CDS-3UTRENST00000374820ENST00000585812PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000589222PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000407086PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000390652PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000408905PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000588462PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000585744PIGUchr20

33231968

-BCAS3chr17

59445688

+
Frame-shitENST00000452740ENST00000588874PIGUchr20

33231968

-BCAS3chr17

59445688

+
5CDS-3UTRENST00000452740ENST00000585812PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000589222PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000407086PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000390652PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000408905PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000588462PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000585744PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3CDSENST00000480175ENST00000588874PIGUchr20

33231968

-BCAS3chr17

59445688

+
intron-3UTRENST00000480175ENST00000585812PIGUchr20

33231968

-BCAS3chr17

59445688

+

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FusionProtFeatures for PIGU_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGU

Q9H490

BCAS3

Q9H6U6

Component of the GPI transamidase complex. May beinvolved in the recognition of either the GPI attachment signal orthe lipid portion of GPI. {ECO:0000269|PubMed:12802054}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGU_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGU_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIGUGPAA1, PIGS, PIGK, PIGT, HS2ST1, KITLG, NRG1, AGTR1, TXNDC15, B3GNT3, LYPD3, PRSS50, ERGIC3, GAL3ST1, FNDC4, LPAR1, GLRA2, PVRL4, CLEC5A, TCTN2, TCTN3, TMEM17, VNN2, SPPL2B, YIPF3, SLC6A15, CDH13, STOMBCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGU_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGU_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource