FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27144

FusionGeneSummary for PIGQ_TMEM241

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGQ_TMEM241
Fusion gene ID: 27144
HgeneTgene
Gene symbol

PIGQ

TMEM241

Gene ID

9091

85019

Gene namephosphatidylinositol glycan anchor biosynthesis class Qtransmembrane protein 241
SynonymsGPI1|c407A10.1C18orf45|hVVT
Cytomap

16p13.3

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol N-acetylglucosaminyltransferase subunit QN-acetylglucosaminyl transferase component Gpi1N-acetylglucosamyl transferase component GPI1PIG-Qc407A10.1 (GPI1 (N-acetylglucosaminyl transferase component))phosphatidylinositol glycan, ctransmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45
Modification date2018052320180519
UniProtAcc

Q9BRB3

Q24JQ0

Ensembl transtripts involved in fusion geneENST00000409527, ENST00000321878, 
ENST00000026218, ENST00000470411, 
ENST00000544860, 
ENST00000450466, 
ENST00000383233, ENST00000542162, 
ENST00000399707, ENST00000475185, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 6=180
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGQ [Title/Abstract] AND TMEM241 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF090869PIGQchr16

633346

+TMEM241chr18

20953727

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409527ENST00000450466PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000409527ENST00000383233PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000409527ENST00000542162PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000409527ENST00000399707PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000409527ENST00000475185PIGQchr16

633346

+TMEM241chr18

20953727

-
3UTR-3CDSENST00000321878ENST00000450466PIGQchr16

633346

+TMEM241chr18

20953727

-
3UTR-3CDSENST00000321878ENST00000383233PIGQchr16

633346

+TMEM241chr18

20953727

-
3UTR-3CDSENST00000321878ENST00000542162PIGQchr16

633346

+TMEM241chr18

20953727

-
3UTR-intronENST00000321878ENST00000399707PIGQchr16

633346

+TMEM241chr18

20953727

-
3UTR-intronENST00000321878ENST00000475185PIGQchr16

633346

+TMEM241chr18

20953727

-
Frame-shiftENST00000026218ENST00000450466PIGQchr16

633346

+TMEM241chr18

20953727

-
Frame-shiftENST00000026218ENST00000383233PIGQchr16

633346

+TMEM241chr18

20953727

-
Frame-shiftENST00000026218ENST00000542162PIGQchr16

633346

+TMEM241chr18

20953727

-
5CDS-intronENST00000026218ENST00000399707PIGQchr16

633346

+TMEM241chr18

20953727

-
5CDS-intronENST00000026218ENST00000475185PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000470411ENST00000450466PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000470411ENST00000383233PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000470411ENST00000542162PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000470411ENST00000399707PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000470411ENST00000475185PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000544860ENST00000450466PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000544860ENST00000383233PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-3CDSENST00000544860ENST00000542162PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000544860ENST00000399707PIGQchr16

633346

+TMEM241chr18

20953727

-
intron-intronENST00000544860ENST00000475185PIGQchr16

633346

+TMEM241chr18

20953727

-

Top

FusionProtFeatures for PIGQ_TMEM241


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGQ

Q9BRB3

TMEM241

Q24JQ0

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine tophosphatidylinositol, the first step of GPI biosynthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PIGQ_TMEM241


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PIGQ_TMEM241


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PIGQ_TMEM241


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PIGQ_TMEM241


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource