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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27141

FusionGeneSummary for PIGN_NUCKS1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGN_NUCKS1
Fusion gene ID: 27141
HgeneTgene
Gene symbol

PIGN

NUCKS1

Gene ID

23556

64710

Gene namephosphatidylinositol glycan anchor biosynthesis class Nnuclear casein kinase and cyclin dependent kinase substrate 1
SynonymsMCAHS|MCAHS1|MCD4|MDC4|PIG-NJC7|NUCKS
Cytomap

18q21.33

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionGPI ethanolamine phosphate transferase 1MCD4 homologphosphatidylinositol-glycan biosynthesis class N proteinnuclear ubiquitous casein and cyclin-dependent kinase substrate 1P1nuclear ubiquitous casein kinase and cyclin-dependent kinase substratepotential LAG1 interactor
Modification date2018052320180519
UniProtAcc

O95427

Q9H1E3

Ensembl transtripts involved in fusion geneENST00000357637, ENST00000400334, 
ENST00000593225, 
ENST00000367142, 
ENST00000464938, 
Fusion gene scores* DoF score4 X 4 X 3=4811 X 15 X 5=825
# samples 418
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/825*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGN [Title/Abstract] AND NUCKS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUCKS1

GO:0031297

replication fork processing

26323318


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ366823PIGNchr18

59713055

-NUCKS1chr1

205715831

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000357637ENST00000367142PIGNchr18

59713055

-NUCKS1chr1

205715831

+
intron-intronENST00000357637ENST00000464938PIGNchr18

59713055

-NUCKS1chr1

205715831

+
intron-intronENST00000400334ENST00000367142PIGNchr18

59713055

-NUCKS1chr1

205715831

+
intron-intronENST00000400334ENST00000464938PIGNchr18

59713055

-NUCKS1chr1

205715831

+
intron-intronENST00000593225ENST00000367142PIGNchr18

59713055

-NUCKS1chr1

205715831

+
intron-intronENST00000593225ENST00000464938PIGNchr18

59713055

-NUCKS1chr1

205715831

+

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FusionProtFeatures for PIGN_NUCKS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGN

O95427

NUCKS1

Q9H1E3

Ethanolamine phosphate transferase involved inglycosylphosphatidylinositol-anchor biosynthesis. Transfersethanolamine phosphate to the first alpha-1,4-linked mannose ofthe glycosylphosphatidylinositol precursor of GPI-anchor (Bysimilarity). May act as suppressor of replication stress andchromosome missegregation. {ECO:0000250,ECO:0000269|PubMed:23446422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGN_NUCKS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGN_NUCKS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGN_NUCKS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGN_NUCKS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIGNC3279775MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 11ORPHANET;UNIPROT