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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27133

FusionGeneSummary for PIGK_KIF21A

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGK_KIF21A
Fusion gene ID: 27133
HgeneTgene
Gene symbol

PIGK

KIF21A

Gene ID

10026

55605

Gene namephosphatidylinositol glycan anchor biosynthesis class Kkinesin family member 21A
SynonymsGPI8CFEOM1|FEOM1|FEOM3A
Cytomap

1p31.1

12q12

Type of geneprotein-codingprotein-coding
DescriptionGPI-anchor transamidaseGPI transamidase subunitGPI8 homologPIG-Kphosphatidylinositol glycan, class Kphosphatidylinositol-glycan biosynthesis class K proteinkinesin-like protein KIF21Akinesin-like protein KIF2renal carcinoma antigen NY-REN-62
Modification date2018052320180523
UniProtAcc

Q92643

Q7Z4S6

Ensembl transtripts involved in fusion geneENST00000370812, ENST00000445065, 
ENST00000370813, ENST00000359130, 
ENST00000478391, 
ENST00000361961, 
ENST00000395670, ENST00000544797, 
ENST00000361418, ENST00000541463, 
ENST00000547745, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 5 X 4=120
# samples 56
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGK [Title/Abstract] AND KIF21A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB243604PIGKchr1

77595295

-KIF21Achr12

39726154

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000370812ENST00000361961PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370812ENST00000395670PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370812ENST00000544797PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370812ENST00000361418PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370812ENST00000541463PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-intronENST00000370812ENST00000547745PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000445065ENST00000361961PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000445065ENST00000395670PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000445065ENST00000544797PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000445065ENST00000361418PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000445065ENST00000541463PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-intronENST00000445065ENST00000547745PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370813ENST00000361961PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370813ENST00000395670PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370813ENST00000544797PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370813ENST00000361418PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000370813ENST00000541463PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-intronENST00000370813ENST00000547745PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000359130ENST00000361961PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000359130ENST00000395670PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000359130ENST00000544797PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000359130ENST00000361418PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000359130ENST00000541463PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-intronENST00000359130ENST00000547745PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000478391ENST00000361961PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000478391ENST00000395670PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000478391ENST00000544797PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000478391ENST00000361418PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-3CDSENST00000478391ENST00000541463PIGKchr1

77595295

-KIF21Achr12

39726154

+
intron-intronENST00000478391ENST00000547745PIGKchr1

77595295

-KIF21Achr12

39726154

+

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FusionProtFeatures for PIGK_KIF21A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGK

Q92643

KIF21A

Q7Z4S6

Mediates GPI anchoring in the endoplasmic reticulum, byreplacing a protein's C-terminal GPI attachment signal peptidewith a pre-assembled GPI. During this transamidation reaction, theGPI transamidase forms a carbonyl intermediate with the substrateprotein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGK_KIF21A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGK_KIF21A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGK_KIF21A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGK_KIF21A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF21AC1851102Fibrosis Of Extraocular Muscles, Congenital, 14ORPHANET;UNIPROT
TgeneKIF21AC0149925Small cell carcinoma of lung1CTD_human