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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27130

FusionGeneSummary for PIGG_PIGG

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGG_PIGG
Fusion gene ID: 27130
HgeneTgene
Gene symbol

PIGG

PIGG

Gene ID

54872

54872

Gene namephosphatidylinositol glycan anchor biosynthesis class Gphosphatidylinositol glycan anchor biosynthesis class G
SynonymsGPI7|LAS21|MRT53|PRO4405|RLGS1930GPI7|LAS21|MRT53|PRO4405|RLGS1930
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionGPI ethanolamine phosphate transferase 2phosphatidylinositol-glycan biosynthesis class G proteinGPI ethanolamine phosphate transferase 2phosphatidylinositol-glycan biosynthesis class G protein
Modification date2018052320180523
UniProtAcc

Q5H8A4

Q5H8A4

Ensembl transtripts involved in fusion geneENST00000296306, ENST00000310340, 
ENST00000453061, ENST00000504346, 
ENST00000383028, ENST00000536264, 
ENST00000502311, ENST00000503111, 
ENST00000509768, 
ENST00000296306, 
ENST00000310340, ENST00000453061, 
ENST00000504346, ENST00000383028, 
ENST00000536264, ENST00000502311, 
ENST00000503111, ENST00000509768, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 4 X 3=36
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIGG [Title/Abstract] AND PIGG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIGG

GO:0006506

GPI anchor biosynthetic process

15632136

TgenePIGG

GO:0006506

GPI anchor biosynthetic process

15632136


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA312347PIGGchr4

533164

-PIGGchr4

532939

+
ChiTaRS3.1T92289PIGGchr4

520825

-PIGGchr4

520859

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000296306ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000296306ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000296306ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000296306ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000296306ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000296306ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000296306ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000296306ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000296306ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000310340ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000310340ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000310340ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000310340ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000310340ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000310340ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000310340ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000310340ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000310340ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000453061ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000453061ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000453061ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000453061ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000453061ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000453061ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000453061ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000453061ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000453061ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000504346ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000504346ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000504346ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000504346ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000504346ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000504346ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000504346ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000504346ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000504346ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000383028ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000383028ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000383028ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000383028ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-3UTRENST00000383028ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000383028ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000383028ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000383028ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
3UTR-intronENST00000383028ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000536264ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000536264ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000536264ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000536264ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000536264ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000536264ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000536264ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000536264ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000536264ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000502311ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000502311ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000502311ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000502311ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000502311ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000502311ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000502311ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000502311ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000502311ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000503111ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000503111ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000503111ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000503111ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000503111ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000503111ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000503111ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000503111ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000503111ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000509768ENST00000296306PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000509768ENST00000310340PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000509768ENST00000453061PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000509768ENST00000504346PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000509768ENST00000383028PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000509768ENST00000536264PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000509768ENST00000502311PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000509768ENST00000503111PIGGchr4

533164

-PIGGchr4

532939

+
intron-intronENST00000509768ENST00000509768PIGGchr4

533164

-PIGGchr4

532939

+
intron-3UTRENST00000296306ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000296306ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000296306ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000296306ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000296306ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000296306ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000296306ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000296306ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000296306ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000310340ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000310340ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000310340ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000310340ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000310340ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000310340ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000310340ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000310340ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000310340ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000453061ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000453061ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000453061ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000453061ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000453061ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000453061ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000453061ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000453061ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000453061ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000504346ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000504346ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000504346ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000504346ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000504346ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000504346ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000504346ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000504346ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000504346ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000383028ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000383028ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000383028ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000383028ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000383028ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000383028ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000383028ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000383028ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000383028ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000536264ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000536264ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000536264ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000536264ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000536264ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000536264ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000536264ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000536264ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000536264ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000502311ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000502311ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000502311ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000502311ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000502311ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000502311ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000502311ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000502311ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000502311ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000503111ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000503111ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000503111ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000503111ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000503111ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000503111ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000503111ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000503111ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000503111ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000509768ENST00000296306PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000509768ENST00000310340PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000509768ENST00000453061PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000509768ENST00000504346PIGGchr4

520825

-PIGGchr4

520859

+
intron-3UTRENST00000509768ENST00000383028PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000509768ENST00000536264PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000509768ENST00000502311PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000509768ENST00000503111PIGGchr4

520825

-PIGGchr4

520859

+
intron-intronENST00000509768ENST00000509768PIGGchr4

520825

-PIGGchr4

520859

+

Top

FusionProtFeatures for PIGG_PIGG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGG

Q5H8A4

PIGG

Q5H8A4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGG_PIGG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGG_PIGG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGG_PIGG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGG_PIGG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource