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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27127

FusionGeneSummary for PIGF_C14orf159

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGF_C14orf159
Fusion gene ID: 27127
HgeneTgene
Gene symbol

PIGF

C14orf159

Gene ID

5281

Gene namephosphatidylinositol glycan anchor biosynthesis class F
Synonyms-
Cytomap

2p21

Type of geneprotein-coding
Descriptionphosphatidylinositol-glycan biosynthesis class F proteinGPI11 homologPIG-F
Modification date20180527
UniProtAcc

Q07326

Ensembl transtripts involved in fusion geneENST00000281382, ENST00000306465, 
ENST00000495933, 		ENST00000298858, 
ENST00000520328, ENST00000256324, 
ENST00000521077, ENST00000518665, 
ENST00000518868, ENST00000519019, 
ENST00000523816, ENST00000525393, 
ENST00000428926, ENST00000522322, 
ENST00000523771, ENST00000412671, 
ENST00000517877, ENST00000523576, 
Fusion gene scores* DoF score3 X 2 X 2=124 X 4 X 4=64
# samples 24
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGF [Title/Abstract] AND C14orf159 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC039303PIGFchr2

46839366

-C14orf159chr14

91691027

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000281382ENST00000298858PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000520328PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000256324PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000521077PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000518665PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000518868PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000519019PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000523816PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000525393PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000428926PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000522322PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000523771PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000412671PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000281382ENST00000517877PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-3UTRENST00000281382ENST00000523576PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000298858PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000520328PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000256324PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000521077PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000518665PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000518868PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000519019PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000523816PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000525393PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000428926PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000522322PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000523771PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000412671PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000306465ENST00000517877PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-3UTRENST00000306465ENST00000523576PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000298858PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000520328PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000256324PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000521077PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000518665PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000518868PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000519019PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000523816PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000525393PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000428926PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000522322PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000523771PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000412671PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-intronENST00000495933ENST00000517877PIGFchr2

46839366

-C14orf159chr14

91691027

+
5CDS-3UTRENST00000495933ENST00000523576PIGFchr2

46839366

-C14orf159chr14

91691027

+

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FusionProtFeatures for PIGF_C14orf159


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGF

Q07326

C14orf159

Involved in GPI-anchor biosynthesis through the transferof ethanolamine phosphate to the third mannose of GPI.{ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGF_C14orf159


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGF_C14orf159


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGF_C14orf159


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGF_C14orf159


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource