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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2712

FusionGeneSummary for ARL15_PARP8

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL15_PARP8
Fusion gene ID: 2712
HgeneTgene
Gene symbol

ARL15

PARP8

Gene ID

54622

79668

Gene nameADP ribosylation factor like GTPase 15poly(ADP-ribose) polymerase family member 8
SynonymsARFRP2ARTD16|pART16
Cytomap

5q11.2

5q11.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2poly [ADP-ribose] polymerase 8ADP-ribosyltransferase diphtheria toxin-like 16
Modification date2018051920180523
UniProtAcc

Q9NXU5

Q8N3A8

Ensembl transtripts involved in fusion geneENST00000502271, ENST00000504924, 
ENST00000510591, ENST00000507646, 
ENST00000514342, ENST00000505697, 
ENST00000511363, ENST00000503750, 
ENST00000281631, ENST00000514067, 
ENST00000505554, ENST00000513738, 
ENST00000503665, 
Fusion gene scores* DoF score11 X 9 X 5=4955 X 3 X 4=60
# samples 115
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL15 [Title/Abstract] AND PARP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KX-01AARL15chr5

53606262

-PARP8chr5

50045985

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000502271ENST00000514342ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-5UTRENST00000502271ENST00000505697ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-3UTRENST00000502271ENST00000511363ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-3UTRENST00000502271ENST00000503750ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-3UTRENST00000502271ENST00000281631ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-3UTRENST00000502271ENST00000514067ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-3UTRENST00000502271ENST00000505554ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-intronENST00000502271ENST00000513738ARL15chr5

53606262

-PARP8chr5

50045985

+
5UTR-intronENST00000502271ENST00000503665ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-5UTRENST00000504924ENST00000514342ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-5UTRENST00000504924ENST00000505697ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000504924ENST00000511363ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000504924ENST00000503750ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000504924ENST00000281631ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000504924ENST00000514067ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000504924ENST00000505554ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-intronENST00000504924ENST00000513738ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-intronENST00000504924ENST00000503665ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-5UTRENST00000510591ENST00000514342ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-5UTRENST00000510591ENST00000505697ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-3UTRENST00000510591ENST00000511363ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-3UTRENST00000510591ENST00000503750ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-3UTRENST00000510591ENST00000281631ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-3UTRENST00000510591ENST00000514067ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-3UTRENST00000510591ENST00000505554ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-intronENST00000510591ENST00000513738ARL15chr5

53606262

-PARP8chr5

50045985

+
intron-intronENST00000510591ENST00000503665ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-5UTRENST00000507646ENST00000514342ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-5UTRENST00000507646ENST00000505697ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000507646ENST00000511363ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000507646ENST00000503750ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000507646ENST00000281631ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000507646ENST00000514067ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-3UTRENST00000507646ENST00000505554ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-intronENST00000507646ENST00000513738ARL15chr5

53606262

-PARP8chr5

50045985

+
5CDS-intronENST00000507646ENST00000503665ARL15chr5

53606262

-PARP8chr5

50045985

+

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FusionProtFeatures for ARL15_PARP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARL15

Q9NXU5

PARP8

Q8N3A8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARL15_PARP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARL15_PARP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARL15GRIPAP1, B4GALT3, FUNDC2, CCDC90B, UBR1, PDE6D, PTN, RPL8, TFG, TUBB2A, CRMP1, GAPDH, UNC119, CNNM1, IREB2, TRPM7, LONRF2, ZNF333, FBXO10, CNNM4, TYW1B, SLC25A20, CNNM2, UBE2K, SLC37A3, RTEL1, NOMO1, AGPAT3, METTL9, SERINC1, NCLN, TMEM120B, TMEM120APARP8YWHAB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARL15_PARP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARL15_PARP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource