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Fusion gene ID: 27088 |
FusionGeneSummary for PIAS4_NID2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIAS4_NID2 | Fusion gene ID: 27088 | Hgene | Tgene | Gene symbol | PIAS4 | NID2 | Gene ID | 51588 | 22795 |
| Gene name | protein inhibitor of activated STAT 4 | nidogen 2 | |
| Synonyms | PIAS-gamma|PIASY|Piasg|ZMIZ6 | NID-2 | |
| Cytomap | 19p13.3 | 14q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 SUMO-protein ligase PIAS4RING-type E3 ubiquitin transferase PIAS4protein inhibitor of activated STAT protein 4protein inhibitor of activated STAT protein PIASyprotein inhibitor of activated STAT protein gammazinc finger, MIZ-type containing 6 | nidogen-2osteonidogen | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q8N2W9 | Q14112 | |
| Ensembl transtripts involved in fusion gene | ENST00000262971, ENST00000596144, | ENST00000541773, ENST00000216286, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 2=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIAS4 [Title/Abstract] AND NID2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIAS4 | GO:0016925 | protein sumoylation | 18579533 |
| Hgene | PIAS4 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
| Hgene | PIAS4 | GO:0045892 | negative regulation of transcription, DNA-templated | 11248056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | N32450 | PIAS4 | chr19 | 4013023 | + | NID2 | chr14 | 52486829 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262971 | ENST00000541773 | PIAS4 | chr19 | 4013023 | + | NID2 | chr14 | 52486829 | - |
| In-frame | ENST00000262971 | ENST00000216286 | PIAS4 | chr19 | 4013023 | + | NID2 | chr14 | 52486829 | - |
| intron-3CDS | ENST00000596144 | ENST00000541773 | PIAS4 | chr19 | 4013023 | + | NID2 | chr14 | 52486829 | - |
| intron-3CDS | ENST00000596144 | ENST00000216286 | PIAS4 | chr19 | 4013023 | + | NID2 | chr14 | 52486829 | - |
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FusionProtFeatures for PIAS4_NID2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIAS4 | NID2 |
| Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53/TP53 pathway, the Wnt pathwayand the steroid hormone signaling pathway. Involved in genesilencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4transcriptional activities through promoting their sumoylations.Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. {ECO:0000269|PubMed:12511558,ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872,ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810,ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508}. | Cell adhesion glycoprotein which is widely distributedin basement membranes. Binds to collagens I and IV, to perlecanand to laminin 1. Does not bind fibulins. It probably has a rolein cell-extracellular matrix interactions. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1016_1084 | 0 | 1376 | Domain | Thyroglobulin type-1 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 108_273 | 0 | 1376 | Domain | NIDO |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 484_524 | 0 | 1376 | Domain | EGF-like 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 528_758 | 0 | 1376 | Domain | Nidogen G2 beta-barrel |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 759_800 | 0 | 1376 | Domain | EGF-like 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 801_843 | 0 | 1376 | Domain | EGF-like 3%3B calcium-binding |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 848_891 | 0 | 1376 | Domain | EGF-like 4 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 892_930 | 0 | 1376 | Domain | EGF-like 5%3B calcium-binding |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 937_1005 | 0 | 1376 | Domain | Thyroglobulin type-1 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1016_1084 | 0 | 1275 | Domain | Thyroglobulin type-1 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 108_273 | 0 | 1275 | Domain | NIDO |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 484_524 | 0 | 1275 | Domain | EGF-like 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 528_758 | 0 | 1275 | Domain | Nidogen G2 beta-barrel |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 759_800 | 0 | 1275 | Domain | EGF-like 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 801_843 | 0 | 1275 | Domain | EGF-like 3%3B calcium-binding |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 848_891 | 0 | 1275 | Domain | EGF-like 4 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 892_930 | 0 | 1275 | Domain | EGF-like 5%3B calcium-binding |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 937_1005 | 0 | 1275 | Domain | Thyroglobulin type-1 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1154_1197 | 0 | 1376 | Repeat | Note=LDL-receptor class B 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1198_1240 | 0 | 1376 | Repeat | Note=LDL-receptor class B 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1241_1285 | 0 | 1376 | Repeat | Note=LDL-receptor class B 3 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1286_1327 | 0 | 1376 | Repeat | Note=LDL-receptor class B 4 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000216286 | - | 0 | 22 | 1329_1373 | 0 | 1376 | Repeat | Note=LDL-receptor class B 5 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1154_1197 | 0 | 1275 | Repeat | Note=LDL-receptor class B 1 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1198_1240 | 0 | 1275 | Repeat | Note=LDL-receptor class B 2 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1241_1285 | 0 | 1275 | Repeat | Note=LDL-receptor class B 3 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1286_1327 | 0 | 1275 | Repeat | Note=LDL-receptor class B 4 |
| Tgene | >NID2 | chr19:4013023 | chr14:52486829 | ENST00000541773 | - | 0 | 22 | 1329_1373 | 0 | 1275 | Repeat | Note=LDL-receptor class B 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIAS4_NID2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000541773_chr14_52486829_-_0aa >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000216286_chr14_52486829_-_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000541773_chr14_52486829_-_0nt >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000216286_chr14_52486829_-_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000541773_chr14_52486829_-_0nt >In-frame_PIAS4_ENST00000262971_chr19_4013023_+_NID2_ENST00000216286_chr14_52486829_-_0nt |
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FusionGenePPI for PIAS4_NID2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIAS4_NID2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIAS4_NID2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NID2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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