FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27085

FusionGeneSummary for PIAS3_REN

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS3_REN
Fusion gene ID: 27085
HgeneTgene
Gene symbol

PIAS3

REN

Gene ID

10401

5972

Gene nameprotein inhibitor of activated STAT 3renin
SynonymsZMIZ5HNFJ2
Cytomap

1q21.1

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5reninangiotensin-forming enzymeangiotensinogenaserenin precursor, renal
Modification date2018051920180523
UniProtAcc

Q9Y6X2

P00797

Ensembl transtripts involved in fusion geneENST00000369299, ENST00000393045, 
ENST00000369298, 
ENST00000367195, 
ENST00000272190, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 1 X 2=4
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PIAS3 [Title/Abstract] AND REN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS3

GO:0033234

negative regulation of protein sumoylation

24651376

HgenePIAS3

GO:0033235

positive regulation of protein sumoylation

17696781|21965678

TgeneREN

GO:0002003

angiotensin maturation

12045255

TgeneREN

GO:0006508

proteolysis

12045255

TgeneREN

GO:0043408

regulation of MAPK cascade

12045255


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-24-2024-01APIAS3chr1

145575404

+RENchr1

204131291

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000369299ENST00000367195PIAS3chr1

145575404

+RENchr1

204131291

-
5UTR-3CDSENST00000369299ENST00000272190PIAS3chr1

145575404

+RENchr1

204131291

-
intron-3CDSENST00000393045ENST00000367195PIAS3chr1

145575404

+RENchr1

204131291

-
intron-3CDSENST00000393045ENST00000272190PIAS3chr1

145575404

+RENchr1

204131291

-
intron-3CDSENST00000369298ENST00000367195PIAS3chr1

145575404

+RENchr1

204131291

-
intron-3CDSENST00000369298ENST00000272190PIAS3chr1

145575404

+RENchr1

204131291

-

Top

FusionProtFeatures for PIAS3_REN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIAS3

Q9Y6X2

REN

P00797

Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway and the steroid hormone signalingpathway. Involved in regulating STAT3 signaling via inhibitingSTAT3 DNA-binding and suppressing cell growth. Enhances thesumoylation of MTA1 and may participate in its paralog-selectivesumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2which promotes its interaction with SIRT1 (PubMed:25406032).Diminishes the sumoylation of ZFHX3 by preventing thecolocalization of ZFHX3 with SUMO1 in the nucleus(PubMed:24651376). {ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032,ECO:0000269|PubMed:9388184}. Renin is a highly specific endopeptidase, whose onlyknown function is to generate angiotensin I from angiotensinogenin the plasma, initiating a cascade of reactions that produce anelevation of blood pressure and increased sodium retention by thekidney.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PIAS3_REN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PIAS3_REN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIAS3MITF, RELA, GFI1, SMAD2, SMAD3, SMAD4, EP300, CREBBP, HMGA2, STAT3, AR, TRIM32, SIAH2, SIAH1, ZMIZ2, ZMIZ1, UBE2I, SREBF2, GLUL, HABP4, TRIM27, SATB1, CARHSP1, UBA1, PSMC1, C19orf60, TRIM8, RAC1, PPP1CA, ELAVL1, ERBB4, SUMO1, SUMO2, SERBP1, HNRNPK, ZFHX3, PRPF40A, SKIL, NCOA2, CREM, SERPINA10, GEMIN4, SUMO3, CBS, TAB2, TRIM63, TRIM55, HIC1, BCL11A, SMURF2RENKCTD15, ATP6AP2, AGT, TMEM184B, C7orf60


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PIAS3_REN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRENP00797DB00212RemikirenReninsmall moleculeapproved
TgeneRENP00797DB00350MinoxidilReninsmall moleculeapproved|investigational
TgeneRENP00797DB09026AliskirenReninsmall moleculeapproved|investigational

Top

RelatedDiseases for PIAS3_REN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIAS3C0007873Uterine Cervical Neoplasm1CTD_human
TgeneRENC0020538Hypertensive disease17CTD_human
TgeneRENC0011570Mental Depression5PSYGENET
TgeneRENC0011581Depressive disorder5PSYGENET
TgeneRENC0004775Bartter Disease3CTD_human
TgeneRENC0018801Heart failure3CTD_human
TgeneRENC0020649Hypotension3CTD_human;HPO
TgeneRENC0022658Kidney Diseases3CTD_human
TgeneRENC0041696Unipolar Depression3PSYGENET
TgeneRENC0001925Albuminuria2CTD_human
TgeneRENC0001969Alcoholic Intoxication2PSYGENET
TgeneRENC0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneRENC0018800Cardiomegaly2CTD_human
TgeneRENC0027720Nephrosis2CTD_human
TgeneRENC0033687Proteinuria2CTD_human
TgeneRENC0149721Left Ventricular Hypertrophy2CTD_human
TgeneRENC0002871Anemia1CTD_human;HPO
TgeneRENC0005586Bipolar Disorder1PSYGENET
TgeneRENC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneRENC0015934Fetal Growth Retardation1CTD_human
TgeneRENC0016059Fibrosis1CTD_human
TgeneRENC0019080Hemorrhage1CTD_human
TgeneRENC0020540Malignant Hypertension1CTD_human
TgeneRENC0022116Ischemia1CTD_human
TgeneRENC0023890Liver Cirrhosis1CTD_human
TgeneRENC0027051Myocardial Infarction1CTD_human
TgeneRENC0029456Osteoporosis1CTD_human
TgeneRENC0033860Psoriasis1CTD_human
TgeneRENC0038587Substance Withdrawal Syndrome1CTD_human
TgeneRENC0041755Adverse reaction to drug1CTD_human
TgeneRENC0221043Liddle Syndrome1CTD_human
TgeneRENC0242528Azotemia1CTD_human
TgeneRENC0266313Allanson Pantzar McLeod syndrome1CTD_human;HPO;ORPHANET;UNIPROT
TgeneRENC2751310Hyperuricemic Nephropathy, Familial Juvenile 21CTD_human;ORPHANET;UNIPROT