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Fusion gene ID: 27059 |
FusionGeneSummary for PI4KA_FAM19A5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PI4KA_FAM19A5 | Fusion gene ID: 27059 | Hgene | Tgene | Gene symbol | PI4KA | FAM19A5 | Gene ID | 5297 | 25817 |
| Gene name | phosphatidylinositol 4-kinase alpha | family with sequence similarity 19 member A5, C-C motif chemokine like | |
| Synonyms | PI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230 | QLLK5208|TAFA-5|TAFA5|UNQ5208 | |
| Cytomap | 22q11.21 | 22q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, a | protein FAM19A5TAFA protein 5chemokine-like protein TAFA-5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | P42356 | Q7Z5A7 | |
| Ensembl transtripts involved in fusion gene | ENST00000255882, ENST00000572273, ENST00000414196, ENST00000466162, | ENST00000402357, ENST00000358295, ENST00000473898, ENST00000406880, | |
| Fusion gene scores | * DoF score | 15 X 8 X 10=1200 | 6 X 3 X 5=90 |
| # samples | 21 | 6 | |
| ** MAII score | log2(21/1200*10)=-2.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PI4KA [Title/Abstract] AND FAM19A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PI4KA | GO:0016310 | phosphorylation | 25327288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12W-01A | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000255882 | ENST00000402357 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| Frame-shift | ENST00000255882 | ENST00000358295 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5CDS-3UTR | ENST00000255882 | ENST00000473898 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5CDS-3UTR | ENST00000255882 | ENST00000406880 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| In-frame | ENST00000572273 | ENST00000402357 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| In-frame | ENST00000572273 | ENST00000358295 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5CDS-3UTR | ENST00000572273 | ENST00000473898 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5CDS-3UTR | ENST00000572273 | ENST00000406880 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| intron-3CDS | ENST00000414196 | ENST00000402357 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| intron-3CDS | ENST00000414196 | ENST00000358295 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| intron-3UTR | ENST00000414196 | ENST00000473898 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| intron-3UTR | ENST00000414196 | ENST00000406880 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5UTR-3CDS | ENST00000466162 | ENST00000402357 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5UTR-3CDS | ENST00000466162 | ENST00000358295 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5UTR-3UTR | ENST00000466162 | ENST00000473898 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
| 5UTR-3UTR | ENST00000466162 | ENST00000406880 | PI4KA | chr22 | 21147481 | - | FAM19A5 | chr22 | 49103529 | + |
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FusionProtFeatures for PI4KA_FAM19A5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PI4KA | FAM19A5 |
| Acts on phosphatidylinositol (PtdIns) in the firstcommitted step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268,ECO:0000269|PubMed:23229899}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PI4KA_FAM19A5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000402357_chr22_49103529_+_763aa MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPS LRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSIL PSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEM LRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKIL HDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLR DFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNR LYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASS VVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVQE >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000358295_chr22_49103529_+_763aa MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPS LRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSIL PSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEM LRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKIL HDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLR DFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNR LYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASS VVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVQE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000402357_chr22_49103529_+_2291nt ATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGATGAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCT GATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTTCGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCT CGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTCAGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCA CTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTGCATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATAC CTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCGCGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTC TTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAAGAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTC CCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTGAAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGC GGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTTCACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAG TACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCTCCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATG CTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAGGAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCC AACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGACCCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATG AAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGATTTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTA CATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTCAAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCT GTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCAC TTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGCCTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGA GACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTCTACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATC AGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTCATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATC GCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTGACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGG CTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTGATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGG GACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTACAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGAC CAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATCTATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCC GTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGCTATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCC AACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATGAACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGC GAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCTAGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAA TCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTCTGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCA >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000358295_chr22_49103529_+_2291nt ATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGATGAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCT GATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTTCGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCT CGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTCAGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCA CTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTGCATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATAC CTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCGCGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTC TTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAAGAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTC CCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTGAAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGC GGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTTCACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAG TACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCTCCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATG CTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAGGAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCC AACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGACCCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATG AAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGATTTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTA CATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTCAAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCT GTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCAC TTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGCCTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGA GACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTCTACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATC AGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTCATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATC GCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTGACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGG CTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTGATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGG GACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTACAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGAC CAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATCTATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCC GTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGCTATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCC AACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATGAACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGC GAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCTAGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAA TCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTCTGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000402357_chr22_49103529_+_3498nt GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA >In-frame_PI4KA_ENST00000572273_chr22_21147481_-_FAM19A5_ENST00000358295_chr22_49103529_+_4607nt GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA TTTAGCTCCAGAAAGCAAAGAAAACTCGAGTAACACTTGTTTGAAAGAGATCATTAAATGTATTTTGCAAAGCCTAAAGTTATATATTTA ACAGTTTTTATATGTTGTATATTTGTAGAAAATCCTATTTAACAATTAACGTGGCAGTCCCGGCCGTCCTGAGAGTCGGGCCGAGCCCCG TGTGTTTCTGAAGACTCTGGGGGTGGGACACGGCGGGGAGGTGGTGCCCCGCGGACCCCGGGGTGCCAGGCACGGAAGGCGGGACTCTGG GAGAAGCGTGCGGAGGACCGTGGCGTCGGCGTCCCGGATGTGTCGGTCGTGCCCGGGGAGGCCGGGTTCCCCTCGCTGCGGGCCAGGCTT GGCTCCTGATTCCCTCTCTGGTCCCTGTATTGGTCAACACTTGAGCGTACAATATCTTGAACATGCTTCTTCCAATGGGTTTTGTTTCCC ATTTCCTGCCCCTTTCGCCACTCACGGACCTTGAGGCCAGTTGACGGCCCTTCTCCCCACGCCTGTGTCCCCGCGTTCTGAGAAGTCCTC TGTCTTCGTGTCACTAGGTCCAGAAAGTCGCGCCGGGCAGAGGCGCAGGCGGGGCCGGCAGGGCCGAGGAATAAGCGACAATTCTGGTTT TTCTCCCCTGGCCGTCGTTCGCCAGCCTCCTTCATTTTCCTGAGTTCCCGCTGAAGTATATACTACCTATGAGTCCAATTAACATGAGTA TTATGCTAGTTCTATCCTACTAAAAAAAACGTAAAAAAATAACTATATAGAAGCTGTTCCAGCAACCATAGACTGAAGATACGAAAGAAA ATCCATTTATTTAAGACCTGTTCCGGTATCCATGAGGACATAATTTACCTTTCAGTCACCACAAATTTATAGGCATTTGTATCCTGGACT AAAAGAAGGGGCTGAGGTTGGGTTTGTCATCACAGAGGGGGTGGGCCTGGAAAGGGTCCTTCCCAAGCTGCCCCGGCTCCGGCGGCCCGG GCCGGCAGCCTCTGCCAGCCAGCGTCCTCACGGCCTCCCCCTCGCCTGTTTCTTTTGAAAGCAAGTGTAGACACCTTCGAGGGCAGAGAT CGGGAGATTTAAGATGTTACAGCATATTTTTTTTTCTTGTTTTACAGTATTCAATTTTGTGTTGATTCAGCTAAATTATGAAAAATAAAG |
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FusionGenePPI for PI4KA_FAM19A5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PI4KA | STRN4, LCK, MRPL44, TNNT1, C8orf33, HARS, FN1, VCAM1, ITGA4, CCDC8, CD274, CA14, HLA-B, HLA-C, CD244, TGOLN2, NTRK1, MED4, MED20, SORT1, SYNCRIP, MRPL1, BAG6, FOXL1, NDUFA4, C17orf89, CDH1, PPP3CB, PPP3CC, PI4KAP1, PLBD1, SERPINB7, SERPINB2, KLK5, KLK7, POF1B, A2ML1, CRYAB, SDR9C7, ECM1, JUP, ADH7, TYMP, IVL, HAL, FLG, CDSN, UBR4, OPRM1, RGS20, SERPINA12, RNASE7, SBSN, NEFH, CHRM3, C5AR2, FAM174A, S100A9, CALML3, NPY2R, SDC2, NCCRP1, DSG1, TGM1, SERPINB13, CD83, DSC2, EVPL, DUSP14, LOR, CD79B, MTNR1B, TRIM25 | FAM19A5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PI4KA_FAM19A5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PI4KA_FAM19A5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PI4KA | C0036341 | Schizophrenia | 4 | PSYGENET |
| Hgene | PI4KA | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | PI4KA | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Hgene | PI4KA | C4225295 | POLYMICROGYRIA, PERISYLVIAN, WITH CEREBELLAR HYPOPLASIA AND ARTHROGRYPOSIS | 1 | UNIPROT |
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