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Fusion gene ID: 27047 |
FusionGeneSummary for PI4K2A_AS3MT |
Fusion gene summary |
Fusion gene information | Fusion gene name: PI4K2A_AS3MT | Fusion gene ID: 27047 | Hgene | Tgene | Gene symbol | PI4K2A | AS3MT | Gene ID | 55361 | 57412 |
Gene name | phosphatidylinositol 4-kinase type 2 alpha | arsenite methyltransferase | |
Synonyms | PI4KII|PIK42A | CYT19 | |
Cytomap | 10q24.2 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 4-kinase type 2-alphaphosphatidylinositol 4-kinase type II (PI4KII)phosphatidylinositol 4-kinase type II-alpha | arsenite methyltransferaseS-adenosyl-L-methionine:arsenic(III) methyltransferaseS-adenosylmethionine:arsenic (III) methyltransferasearsenic (+3 oxidation state) methyltransferasemethylarsonite methyltransferasemethyltransferase cyt19 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BTU6 | Q9HBK9 | |
Ensembl transtripts involved in fusion gene | ENST00000555577, ENST00000370649, ENST00000370631, | ENST00000369880, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PI4K2A [Title/Abstract] AND AS3MT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PI4K2A | GO:0006661 | phosphatidylinositol biosynthetic process | 11279162 |
Hgene | PI4K2A | GO:0046854 | phosphatidylinositol phosphorylation | 25168678 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-J9-A8CK-01A | PI4K2A | chr10 | 99426877 | + | AS3MT | chr10 | 104650301 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000555577 | ENST00000369880 | PI4K2A | chr10 | 99426877 | + | AS3MT | chr10 | 104650301 | + |
In-frame | ENST00000370649 | ENST00000369880 | PI4K2A | chr10 | 99426877 | + | AS3MT | chr10 | 104650301 | + |
In-frame | ENST00000370631 | ENST00000369880 | PI4K2A | chr10 | 99426877 | + | AS3MT | chr10 | 104650301 | + |
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FusionProtFeatures for PI4K2A_AS3MT |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PI4K2A | AS3MT |
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol(PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid thatplays important roles in endocytosis, Golgi function, proteinsorting and membrane trafficking and is required for prolongedsurvival of neurons. Besides, phosphorylation ofphosphatidylinositol (PI) to phosphatidylinositol 4-phosphate(PI4P) is the first committed step in the generation ofphosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of thesecond messenger inositol 1,4,5-trisphosphate (InsP3).{ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754,ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885,ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678,ECO:0000305}. | Catalyzes the transfer of a methyl group from AdoMet totrivalent arsenicals producing methylated and dimethylatedarsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase tomethylarsonite, Me-As(OH)2. Methylarsonite is also a substrate andit is converted into the much less toxic compound dimethylarsinate(cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PI4K2A | chr10:99426877 | chr10:104650301 | ENST00000370631 | + | 8 | 9 | 39_42 | 426 | 480 | Compositional bias | Note=Poly-Ala |
Hgene | PI4K2A | chr10:99426877 | chr10:104650301 | ENST00000370631 | + | 8 | 9 | 65_97 | 426 | 480 | Compositional bias | Note=Ala-rich |
Hgene | PI4K2A | chr10:99426877 | chr10:104650301 | ENST00000370631 | + | 8 | 9 | 131_137 | 426 | 480 | Nucleotide binding | ATP |
Hgene | PI4K2A | chr10:99426877 | chr10:104650301 | ENST00000370631 | + | 8 | 9 | 261_264 | 426 | 480 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PI4K2A | chr10:99426877 | chr10:104650301 | ENST00000370631 | + | 8 | 9 | 133_438 | 426 | 480 | Domain | Note=PI3K/PI4K |
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FusionGeneSequence for PI4K2A_AS3MT |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PI4K2A_ENST00000555577_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_477aa MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGAVGGVCALANVLGAQVCQL ERLCCTGQWEDAQKLQHRLIEPNAARIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPR TKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISD PNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKL >In-frame_PI4K2A_ENST00000370649_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_477aa MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGAVGGVCALANVLGAQVCQL ERLCCTGQWEDAQKLQHRLIEPNAARIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPR TKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISD PNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKL >In-frame_PI4K2A_ENST00000370631_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_507aa MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAA AAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDA DYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQEGEIVEVDEETAAILKNSRFAQDF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PI4K2A_ENST00000555577_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_1431nt ATGCTGGGTCCCCAAGTCTGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGG AAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAAT CTGCACAAACTGGGCACCTTCCCCTTCCGAGGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTG GAGCGACTGTGCTGCACGGGGCAATGGGAAGATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGAGGATCATTGCTGTC TTCAAACCCAAGAATGAAGAGCCCTATGGGCATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGC CGTGACTGCCTTGTCCTTAACCAGGGCTATCTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGT ACAAAGGTAGTATACCTGGCCAGTGAGACCTTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAA GTGCCAAAAGTTGGACAGCGGTTTAACCGCATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCA GACTATTGGCTGCGGCGTTTTGAAGCAGAACCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTG GATTACATCATCCGCAACACTGATCGAGGCAATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACA GACTGGGTGGTGGTGAAGGAGCCTGTTATCAAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGG GCATATCCTTTTTACTGGGCCTGGTTGCCCCAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGAC CCTAACTTCGTCAAGGACTTGGAAGAGGACCTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATT GCTGTCATGCGGGGCCAGGAAGGTGAAATTGTTGAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTT CTGATCAGACCAATTGGAGAGAAGTTGCCAACATCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTT >In-frame_PI4K2A_ENST00000370649_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_1431nt ATGCTGGGTCCCCAAGTCTGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGG AAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAAT CTGCACAAACTGGGCACCTTCCCCTTCCGAGGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTG GAGCGACTGTGCTGCACGGGGCAATGGGAAGATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGAGGATCATTGCTGTC TTCAAACCCAAGAATGAAGAGCCCTATGGGCATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGC CGTGACTGCCTTGTCCTTAACCAGGGCTATCTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGT ACAAAGGTAGTATACCTGGCCAGTGAGACCTTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAA GTGCCAAAAGTTGGACAGCGGTTTAACCGCATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCA GACTATTGGCTGCGGCGTTTTGAAGCAGAACCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTG GATTACATCATCCGCAACACTGATCGAGGCAATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACA GACTGGGTGGTGGTGAAGGAGCCTGTTATCAAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGG GCATATCCTTTTTACTGGGCCTGGTTGCCCCAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGAC CCTAACTTCGTCAAGGACTTGGAAGAGGACCTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATT GCTGTCATGCGGGGCCAGGAAGGTGAAATTGTTGAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTT CTGATCAGACCAATTGGAGAGAAGTTGCCAACATCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTT >In-frame_PI4K2A_ENST00000370631_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_1521nt ATGGACGAGACGAGCCCACTAGTGTCCCCCGAGCGGGCCCAACCCCCGGACTACACCTTCCCGTCGGGCTCGGGCGCTCACTTTCCGCAG GTGCCCGGGGGCGCGGTCCGAGTGGCGGCGGCGGCCGGCTCGGGCCCCTCTCCGCCGGGCTCGCCGGGCCACGACCGCGAGCGGCAGCCA CTGTTGGATCGGGCCCGGGGCGCGGCGGCCCAGGGCCAGACCCAAACCGTGGCGGCGCAGGCCCAGGCTCTGGCCGCTCAGGCCGCGGCG GCAGCCCACGCCGCTCAGGCCCACCGCGAGCGGAACGAGTTCCCGGAGGATCCTGAGTTCGAGGCGGTGGTGCGGCAGGCCGAGCTGGCC ATCGAGCGCTGCATCTTTCCCGAGCGCATCTACCAGGGCTCCAGCGGAAGCTACTTCGTCAAGGACCCTCAGGGGAGGATCATTGCTGTC TTCAAACCCAAGAATGAAGAGCCCTATGGGCATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGC CGTGACTGCCTTGTCCTTAACCAGGGCTATCTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGT ACAAAGGTAGTATACCTGGCCAGTGAGACCTTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAA GTGCCAAAAGTTGGACAGCGGTTTAACCGCATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCA GACTATTGGCTGCGGCGTTTTGAAGCAGAACCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTG GATTACATCATCCGCAACACTGATCGAGGCAATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACA GACTGGGTGGTGGTGAAGGAGCCTGTTATCAAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGG GCATATCCTTTTTACTGGGCCTGGTTGCCCCAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGAC CCTAACTTCGTCAAGGACTTGGAAGAGGACCTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATT GCTGTCATGCGGGGCCAGGAAGGTGAAATTGTTGAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTT CTGATCAGACCAATTGGAGAGAAGTTGCCAACATCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PI4K2A_ENST00000555577_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_2960nt GTGGGAGGAGGGCCCAGATCCCACTGGAGATACCGAAGGAGATACTCTTTAGTATTGGGATCCCAGAAACCAGTCCTATATCTGGCCAGA GGGACACTGGGTTGTGGCATCTCTCTAGCTGCTACCCAGAAGGAACAGGGCCCCCTGGGGCCTATAGGCCTTGCCCCTGACCCTGGGAAC ACCCAGCTCAGGCCTGCCCCAGTGGCCACAAGTCAGGGAGGCCGCAAATTTTTAACTAGAAACATTGATCATTAATAGGGGGTTAGAAAG AGTTCAAACTAAGTCTCACTCTGGGACATAGACCAATTGTGCTTCAGGCCTCCTGCAGAGATGCTGGGTCCCCAAGTCTGGTCTTCTGTG AGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCC CCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAATCTGCACAAACTGGGCACCTTCCCCTTCCGA GGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTGGAGCGACTGTGCTGCACGGGGCAATGGGAA GATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGAGGATCATTGCTGTCTTCAAACCCAAGAATGAAGAGCCCTATGGG CATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGCCGTGACTGCCTTGTCCTTAACCAGGGCTAT CTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGTACAAAGGTAGTATACCTGGCCAGTGAGACC TTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAAGTGCCAAAAGTTGGACAGCGGTTTAACCGC ATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCAGACTATTGGCTGCGGCGTTTTGAAGCAGAA CCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTGGATTACATCATCCGCAACACTGATCGAGGC AATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACAGACTGGGTGGTGGTGAAGGAGCCTGTTATC AAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGGGCATATCCTTTTTACTGGGCCTGGTTGCCC CAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGACCCTAACTTCGTCAAGGACTTGGAAGAGGAC CTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATTGCTGTCATGCGGGGCCAGGAAGGTGAAATT GTTGAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTTCTGATCAGACCAATTGGAGAGAAGTTGCCA ACATCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTTGCAGAAGAGTCTGACAGTATGAAGTCCAGA TGTGTCCCTGATGCTGCTGGAGGCTGCTGTGGCACAAAGAAAAGCTGCTAAATCTATAGCCAACCAGGGGACCACAGTAGTGGGCAAGAG TGATCTGCATGTTTTTTAACCTGCTTTTCCCCATAGCACAGACCATAAGAAACAACAAATGGGGCCGGGCACAGTGGCTCATGCCTATAA TCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAATCCTGTCTCTA CCAAAAATACAAAAAAAATTAGCTGGGCATGGTGGTGCACACCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAAC CCAGGAAGTAGAGGCTGCAGTGAGTAAGCATCACGCCACTGTACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGCAAAAAAA AAAAAAAAAAAAGAAAGAAAGAAAAAGAAAACAACAAATGGCAGAGAGCCACCATATTCCAAATCACTGAAAAAAATAAATGAATTATTT TTATTTATTTATTTATTTTTTTGAGATGGAGTCTCGGTCTGTTGCCCAGGCTGAAGTGCAGTGGCCCCATCTCAACTCACTGCAAGCTCC ACCTCCTGGGTTCACGCCATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGACTACAGGCACCTACCACCATGCCCAGCTAATTTTTTGTA TTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGC TGGGATTACAAGCATGAGCCACTGCGCCCGGCCATAAATGAATTATTTTTAAGAGGCATTGATTAAAGATTCACAGCAAATCACTAGTTA AGCAGATTTTTTTTCTATTTCCTACTTCAAAGTTCTGGTGCCACATAGTGGTCAGAAATGGAACAGAGAAGCTGTCTTAAGCCTTGTTCA AGAAGCAGGAAAGGCATCAGAAGAAGTAACAGTTGGCAGAGGGTCTCAGGAAAAACATCTTCCTTCTGATCTTTTGCATAGCACCTTTTG GAATTTTCATCATGTTTGCTTATTAAACAAAGCTCCTACTGCCATCATACTAATCATGCAAAAAGATTGCCAAATCATGTTTGGTAGGAG >In-frame_PI4K2A_ENST00000370649_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_2960nt GTGGGAGGAGGGCCCAGATCCCACTGGAGATACCGAAGGAGATACTCTTTAGTATTGGGATCCCAGAAACCAGTCCTATATCTGGCCAGA GGGACACTGGGTTGTGGCATCTCTCTAGCTGCTACCCAGAAGGAACAGGGCCCCCTGGGGCCTATAGGCCTTGCCCCTGACCCTGGGAAC ACCCAGCTCAGGCCTGCCCCAGTGGCCACAAGTCAGGGAGGCCGCAAATTTTTAACTAGAAACATTGATCATTAATAGGGGGTTAGAAAG AGTTCAAACTAAGTCTCACTCTGGGACATAGACCAATTGTGCTTCAGGCCTCCTGCAGAGATGCTGGGTCCCCAAGTCTGGTCTTCTGTG AGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCC CCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAATCTGCACAAACTGGGCACCTTCCCCTTCCGA GGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTGGAGCGACTGTGCTGCACGGGGCAATGGGAA GATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGAGGATCATTGCTGTCTTCAAACCCAAGAATGAAGAGCCCTATGGG CATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGCCGTGACTGCCTTGTCCTTAACCAGGGCTAT CTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGTACAAAGGTAGTATACCTGGCCAGTGAGACC TTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAAGTGCCAAAAGTTGGACAGCGGTTTAACCGC ATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCAGACTATTGGCTGCGGCGTTTTGAAGCAGAA CCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTGGATTACATCATCCGCAACACTGATCGAGGC AATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACAGACTGGGTGGTGGTGAAGGAGCCTGTTATC AAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGGGCATATCCTTTTTACTGGGCCTGGTTGCCC CAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGACCCTAACTTCGTCAAGGACTTGGAAGAGGAC CTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATTGCTGTCATGCGGGGCCAGGAAGGTGAAATT GTTGAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTTCTGATCAGACCAATTGGAGAGAAGTTGCCA ACATCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTTGCAGAAGAGTCTGACAGTATGAAGTCCAGA TGTGTCCCTGATGCTGCTGGAGGCTGCTGTGGCACAAAGAAAAGCTGCTAAATCTATAGCCAACCAGGGGACCACAGTAGTGGGCAAGAG TGATCTGCATGTTTTTTAACCTGCTTTTCCCCATAGCACAGACCATAAGAAACAACAAATGGGGCCGGGCACAGTGGCTCATGCCTATAA TCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAATCCTGTCTCTA CCAAAAATACAAAAAAAATTAGCTGGGCATGGTGGTGCACACCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAAC CCAGGAAGTAGAGGCTGCAGTGAGTAAGCATCACGCCACTGTACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGCAAAAAAA AAAAAAAAAAAAGAAAGAAAGAAAAAGAAAACAACAAATGGCAGAGAGCCACCATATTCCAAATCACTGAAAAAAATAAATGAATTATTT TTATTTATTTATTTATTTTTTTGAGATGGAGTCTCGGTCTGTTGCCCAGGCTGAAGTGCAGTGGCCCCATCTCAACTCACTGCAAGCTCC ACCTCCTGGGTTCACGCCATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGACTACAGGCACCTACCACCATGCCCAGCTAATTTTTTGTA TTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGC TGGGATTACAAGCATGAGCCACTGCGCCCGGCCATAAATGAATTATTTTTAAGAGGCATTGATTAAAGATTCACAGCAAATCACTAGTTA AGCAGATTTTTTTTCTATTTCCTACTTCAAAGTTCTGGTGCCACATAGTGGTCAGAAATGGAACAGAGAAGCTGTCTTAAGCCTTGTTCA AGAAGCAGGAAAGGCATCAGAAGAAGTAACAGTTGGCAGAGGGTCTCAGGAAAAACATCTTCCTTCTGATCTTTTGCATAGCACCTTTTG GAATTTTCATCATGTTTGCTTATTAAACAAAGCTCCTACTGCCATCATACTAATCATGCAAAAAGATTGCCAAATCATGTTTGGTAGGAG >In-frame_PI4K2A_ENST00000370631_chr10_99426877_+_AS3MT_ENST00000369880_chr10_104650301_+_2777nt CGGCCGCGAGCGCAGTGGTGTGGAGCGCGCCGGGTCCCGGAGCCGGCTGTCTGAGGGATGGACGAGACGAGCCCACTAGTGTCCCCCGAG CGGGCCCAACCCCCGGACTACACCTTCCCGTCGGGCTCGGGCGCTCACTTTCCGCAGGTGCCCGGGGGCGCGGTCCGAGTGGCGGCGGCG GCCGGCTCGGGCCCCTCTCCGCCGGGCTCGCCGGGCCACGACCGCGAGCGGCAGCCACTGTTGGATCGGGCCCGGGGCGCGGCGGCCCAG GGCCAGACCCAAACCGTGGCGGCGCAGGCCCAGGCTCTGGCCGCTCAGGCCGCGGCGGCAGCCCACGCCGCTCAGGCCCACCGCGAGCGG AACGAGTTCCCGGAGGATCCTGAGTTCGAGGCGGTGGTGCGGCAGGCCGAGCTGGCCATCGAGCGCTGCATCTTTCCCGAGCGCATCTAC CAGGGCTCCAGCGGAAGCTACTTCGTCAAGGACCCTCAGGGGAGGATCATTGCTGTCTTCAAACCCAAGAATGAAGAGCCCTATGGGCAT CTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGCCGTGACTGCCTTGTCCTTAACCAGGGCTATCTC TCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGTACAAAGGTAGTATACCTGGCCAGTGAGACCTTC AACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAAGTGCCAAAAGTTGGACAGCGGTTTAACCGCATC GGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCAGACTATTGGCTGCGGCGTTTTGAAGCAGAACCT CTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTGGATTACATCATCCGCAACACTGATCGAGGCAAT GACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACAGACTGGGTGGTGGTGAAGGAGCCTGTTATCAAG GTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGGGCATATCCTTTTTACTGGGCCTGGTTGCCCCAG GCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGACCCTAACTTCGTCAAGGACTTGGAAGAGGACCTA TATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATTGCTGTCATGCGGGGCCAGGAAGGTGAAATTGTT GAAGTGGATGAAGAAACAGCAGCTATCTTGAAGAATTCAAGATTTGCTCAAGATTTTCTGATCAGACCAATTGGAGAGAAGTTGCCAACA TCTGGAGGCTGTTCTGCTTTGGAGTTAAAGGATATAATCACAGATCCATTTAAGCTTGCAGAAGAGTCTGACAGTATGAAGTCCAGATGT GTCCCTGATGCTGCTGGAGGCTGCTGTGGCACAAAGAAAAGCTGCTAAATCTATAGCCAACCAGGGGACCACAGTAGTGGGCAAGAGTGA TCTGCATGTTTTTTAACCTGCTTTTCCCCATAGCACAGACCATAAGAAACAACAAATGGGGCCGGGCACAGTGGCTCATGCCTATAATCC CAGCACTTTGGGAGGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAATCCTGTCTCTACCA AAAATACAAAAAAAATTAGCTGGGCATGGTGGTGCACACCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCA GGAAGTAGAGGCTGCAGTGAGTAAGCATCACGCCACTGTACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGCAAAAAAAAAA AAAAAAAAAGAAAGAAAGAAAAAGAAAACAACAAATGGCAGAGAGCCACCATATTCCAAATCACTGAAAAAAATAAATGAATTATTTTTA TTTATTTATTTATTTTTTTGAGATGGAGTCTCGGTCTGTTGCCCAGGCTGAAGTGCAGTGGCCCCATCTCAACTCACTGCAAGCTCCACC TCCTGGGTTCACGCCATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGACTACAGGCACCTACCACCATGCCCAGCTAATTTTTTGTATTT TTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGG GATTACAAGCATGAGCCACTGCGCCCGGCCATAAATGAATTATTTTTAAGAGGCATTGATTAAAGATTCACAGCAAATCACTAGTTAAGC AGATTTTTTTTCTATTTCCTACTTCAAAGTTCTGGTGCCACATAGTGGTCAGAAATGGAACAGAGAAGCTGTCTTAAGCCTTGTTCAAGA AGCAGGAAAGGCATCAGAAGAAGTAACAGTTGGCAGAGGGTCTCAGGAAAAACATCTTCCTTCTGATCTTTTGCATAGCACCTTTTGGAA TTTTCATCATGTTTGCTTATTAAACAAAGCTCCTACTGCCATCATACTAATCATGCAAAAAGATTGCCAAATCATGTTTGGTAGGAGGAC |
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FusionGenePPI for PI4K2A_AS3MT |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PI4K2A | CD7, GABARAP, HSP90AA1, NOS3, RAD23A, APP, ECSIT, TSPAN3, TMEM231, CLTB, KIF11, CNOT1, PHF8, TMEM206, PVR, IRGC, MBLAC2, P2RX1, TPCN2, KIF3A, TNFRSF10A, FANCE | AS3MT | RHOU |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PI4K2A_AS3MT |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | AS3MT | Q9HBK9 | DB00118 | Ademetionine | Arsenite methyltransferase | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PI4K2A_AS3MT |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | AS3MT | C0311375 | Arsenic Poisoning | 2 | CTD_human |
Tgene | AS3MT | C0005612 | Birth Weight | 1 | CTD_human |
Tgene | AS3MT | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | AS3MT | C0027660 | Neoplasms, Glandular and Epithelial | 1 | CTD_human |
Tgene | AS3MT | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |